Drugs, Drug Targets and You: Exploring the Molecular Mechanisms of Drug Abuse wit

描述(由申请者提供)：药物，药物靶点和你是一个多方面的项目，旨在让高中生积极探索药物使用的分子基础及其对他们身体的影响。通过使用各种创新的、以学生为中心的教学工具，该项目将让学生积极研究药物--具有定义的3D形状的小分子--如何与目标蛋白质上的特定活性部位结合，以改变它们在控制我们每一个想法和行动的信号神经传输中的正常功能。为了确保这些教学工具在高中课堂上的有效性，我们使用了反向设计过程，在这个过程中，(I)仔细阐述的学习目标驱动着每个教学工具的发展，(Ii)每个学习目标都明确地与生命科学中的一个基本的基本概念联系在一起。因此，使用这些材料的学生变得积极地参与构建他们自己的关于药物使用的分子后果的知识，因为他们将这种理解层层到化学和物理的基本概念上。该项目将补充和改进现有的教学材料，利用以学生为中心的教学工具，吸引学生积极探索这一主题，包括：(I)药物及其结合的蛋白质的物理模型(通过3D打印技术创建)，(Ii)动手构建工具包，学生在其中创建突触或神经元中产生的动作电位的模型，(Iii)在细胞环境中呈现这些药物靶标蛋白质的独特细胞景观，并将学生的思维从宏观-细胞-到分子水平转移。这些独特的视觉和触觉教学工具的使用随后导致基于交互式计算机的可视化工具的使用，这些可视化工具建立在用动手工具建立的初始概念之上， 并允许在计算机环境中探索更复杂的概念。我们将使用准实验研究设计来研究这种分子方法对药物滥用教育的影响，在该设计中，两组匹配的高中教师接受培训，在他们的课堂上使用材料。最后，在该项目的后期阶段，我们将参与 48个州的9000名高中生在参加国家科学奥林匹克竞赛的蛋白质建模活动时，考虑到吸毒的分子后果。

DESCRIPTION (provided by applicant): Drugs, Drug Targets and You is a multi-faceted project aimed at engaging high school students in an active exploration of the molecular basis of drug use and its consequences on their bodies. Through the use of a variety of innovative, student-centered instructional tools, the project will engage students in an active investigation o how drugs - small molecules with defined 3D shapes - bind to specific active sites on target proteins to modify their normal function in the neurotransmission of signals that control our every thought and action. To insure the usefulness of these instructional tools in high school classrooms, we use a backwards design process in which (i) carefully articulated learning goals drive the development of each instructional tool, and (ii) each learning goal is explicitly tied toa fundamental, foundational concept in the life sciences. As a result, students using these materials become actively engaged in constructing their own knowledge of the molecular consequences of drug use, as they layer this understanding onto foundational concepts of chemistry and physics. This project will complement and enhance currently existing instructional materials by drawing students into an active exploration of the topic using student-centered instructional tools, including: (i) physical models of drugs and the proteins to which they bind (created by 3D printing technologies), (ii) hands-on construction kits in which students create a model of a synapse or the action potential generated in a neuron and (iii) unique cellular landscapes that present these drug target proteins in their cellular context, and transition students' thinking from the macroscopic - to the cellular - to the molecular level. The use of these unique visual and tactile instructional tools then leads to the use of interactive computer-based visualization tools that build upon the initial concepts established with the hands-on tools, and allow for the exploration of more sophisticated concepts in the computer environment. We will study the impact of this molecular approach to drug abuse education using a quasi-experimental study design in which two matched cohorts of high school teachers are trained to use the materials in their classrooms. Finally, in the later stages of this project, we will engage 9,000 high school students in 48 states in a consideration of the molecular consequences of drug use as they participate in a Protein Modeling event as part of the national Science Olympiad competition.