Bioinformatics Core Facility

生物信息学核心设施

• 批准号: 8340336
• 负责人: CHARLES M. PEROU
• 金额: $ 28.63万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-23 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340336
• 关键词: Area; Bioinformatics; Biological Assay; Biological Models; Cancer Center; Cancer Survivorship; Clinical; Clinical Data; Core Facility; Data; Data Analyses; Data Set; Data Storage and Retrieval; Databases; Development; Elements; Faculty; Fostering; Gene Expression; Gene Expression Microarray Analysis; Genomics; Genotype; Goals; Grant; Human Resources; Link; Maintenance; Mission; Patients; Research; Research Infrastructure; Research Personnel; Resources; Sampling; Specimen; System; Technology; Tissue Procurements; Translational Research; anticancer research; base; cohort; cost; data integration; data management; experience; member; patient registry; programs; tool; tool development; tumor

Bioinformatics is critical for any cancer center, allowing researchers to tap the ever-growing data sets afforded by new cancer research technologies. However daunting, massive data sets are being created, must be analyzed, and need to be related to translafional and clinical end points. LCCC expertise in this area began with the genomics program, particularly gene expression microarray analysis. By necessity, the personnel, computafional infrastructure, and broad faculty expertise was built through internal and external recruitment. In the last three years, capabilifies rapidly expanded to capture clinical data and annotate specimens. The Lineberger Data Warehouse (LDW) was created to allow Interactive use of mulfiple oracle based data repositories. With this expanded staff and mission, the genomics and bioinformatics were divided into two resources. The relafionships between the Bioinformatics, Biostatisfics and Data Management, Genomics and the new Next Generafion and Genotyping Core will be seamless. The Bioinformafic Core's goals are to confinue to provide bioinformafics tools, databases for the storage and analysis of genomic data, for the storage and analysis of clinical/pafient data, and to provide tools to link these disfinct data types together to foster translational research discoveries. Incorporafion of new enfifies, such as the Cancer Survivorship Cohort, is occurring. The key element remains the Bioinformafics Core Central Patient Registry which provides and tracks all pafients after assigning a unique research identifier. The group has significant experience with genomic database development and curation, genomic data analysis and tool development, clinical database development, and linking these together through the LDW. The core will expand capabilifies to include new genomic plafi'orms and new clinical databases/tumor types. The core requests $270,568, representing 13% of its total operating costs to accomplish its ambitious goals. All core use in 2009 was by members. The co-directors, Drs. Perou and Hayes, are leaders in genomic analysis and its integration with clinical endpoints.

生物信息学对任何癌症中心都至关重要，它使研究人员能够利用不断增长的数据集 新的癌症研究技术所提供的。无论创建的数据集多么令人生畏， 必须进行分析，并且需要与患者和临床终点相关。LCCC专业知识 该领域始于基因组学计划，特别是基因表达微阵列分析。出于必要， 人员，计算基础设施和广泛的教师专业知识是通过内部和外部 招聘在过去的三年里，capabilifies迅速扩展到捕获临床数据和注释 标本Lineberger数据仓库（LDW）的创建是为了允许多个Oracle的交互式使用 基于数据仓库。随着人员和使命的扩大，基因组学和生物信息学被分开 两种资源。生物信息学、生物工程学和数据管理之间的关系， 基因组学和新的下一代和基因分型核心将是无缝的。 Bioinformafic Core的目标是提供生物信息学工具、存储数据库， 基因组数据的分析，用于临床/患者数据的存储和分析，并提供链接 这些不同的数据类型一起促进转化研究发现。新的enfifies， 比如癌症幸存者队列。关键要素仍然是生物信息学核心 中央患者登记处，在分配唯一的研究标识符后提供并跟踪所有患者。 该小组在基因组数据库开发和管理、基因组数据 分析和工具开发，临床数据库开发，并通过LDW将这些连接在一起。 该核心将扩大能力，以包括新的基因组质粒和新的临床数据库/肿瘤类型。 核心要求270，568美元，占其总运营成本的13%，以实现其雄心勃勃的目标。 2009年所有核心资源都是由成员使用的。联合主任佩鲁博士和海斯博士是基因组学领域的领导者， 分析及其与临床终点的整合。