Training Program in Endocrine and Diabetes Research

描述（申请人提供）：内分泌相关疾病；糖尿病、代谢综合征、肥胖和骨质疏松症等已成为主要的公共卫生问题，因为它们的患病率、破坏性并发症（心脏病、中风、失明、截肢、透析）以及它们对其他主要疾病（如心血管、肾脏、神经、性腺和消化系统疾病）的不利影响。虽然这些疾病的管理和预防已经成为初级保健医生的任务，但内分泌学家承担着领导研究的责任，以更好地了解疾病的过程，并提供有效的预防和管理策略。这样一个崇高的目标需要积极进取的内分泌学家，他们了解自己的领导作用，并致力于内分泌学、糖尿病和新陈代谢的研究和教育。然而，结合临床技能和研究专长的学术内分泌学家的数量正在减少。大多数内分泌研究项目培养的临床内分泌学家在内分泌研究方面并不熟练，最终转向私人临床实践。本申请的目的是利用韦恩州立大学医学院优秀的学术环境和现有的ACGME内分泌、糖尿病和代谢临床培训项目，引导年轻的内分泌学家进入研究/学术轨道，并在基础、临床和/或转化内分泌研究学科方面激励和培训他们，使他们发展成为成熟/全面的内分泌研究者。本计划每年招收2名学员，根据其先前的学术成就和对生物医学内分泌研究的兴趣，在完成内分泌学、糖尿病和代谢的临床研究后，将进行至少两年的研究培训。该项目将为学员的研究技能的发展和具体化提供一种手段，同时也将成为一个过渡的桥梁机制，使他们有竞争力获得独立的研究基金和学术任命，从而成为未来内分泌研究的领导者。

DESCRIPTION (provided by applicant): Endocrine-related illnesses; such as diabetes, metabolic syndrome, obesity and osteoporosis have become major public health concerns because of their prevalence, their devastating complication (heart attacks, stroke, blindness, amputations, dialysis) and their adverse effects on other major illnesses such as diseases of the cardiovascular, renal, nervous, gonadal and digestive systems. Whereas the management and the prevention of these diseases have become the mandate of primary care physicians, endocrinologists carry the burden of leading research to better understand the disease processes and provide effective prevention and management strategies. Such a noble goal requires motivated endocrinologists who understand their leadership role and who commit to research and education in endocrinology, diabetes and metabolism. However, the number of academic endocrinologists who combine clinical skills and research expertise is decreasing. Most endocrine fellowship programs produce clinical endocrinologists who are not skilled in endocrine investigation and eventually move to private clinical practice. The objective of this application is to take advantage of the excellent academic environment of the Wayne State University School of Medicine and of the existing ACGME clinical training program in endocrinology, diabetes and metabolism to direct young endocrinologists to the research/academic track, and motivate and train them in basic, clinical and/or translational endocrine research disciplines so they may develop into mature/rounded endocrine investigators. This proposal involves 2 trainees/year selected on the basis of prior scholarly achievement and interest in a career in biomedical endocrine investigation, who will spend a minimum of two years in research training after completing their clinical fellowship in endocrinology, diabetes and metabolism. This program shall provide a mean to develop and crystallize the investigative skills of the trainees and at the same time shall become a bridging mechanism for transitioning them to become competitive for independent research funds and academic appointment so they may become the future leaders of endocrine research. PUBLIC HEALTH RELEVANCE: Endocrine diseases, such as diabetes, obesity, metabolic syndrome and osteoporosis are Increasing in prevalence and have devastating complications. This program alms at recruiting, motivating and training young endocrinologists to become ACADEMIC ENDOCRINOLOGISTS leading research fpr a better understanding and effective prevention and management strategies of endocrine-related illnesses.