Patient Oriented Research in Pediatric Motility and Related Disorders

K24职业生涯中期研究人员奖的申请是基于波士顿儿童医院动力和功能性胃肠疾病中心的研究和指导计划。该奖项的主要目标是在几个正在进行的以患者为导向的儿科运动和相关障碍研究项目的背景下，为指导提供保护的时间。主要目标之一是为这一领域的年轻研究人员提供研究、培训和指导。此应用程序中提出了三个主要项目。其中一个重点是使用巴氯芬治疗非酸反流，另一个重点是使用一氧化氮糊剂治疗肛门内括约肌松弛患者的梗阻症状，第三个是翻译项目，这是一个更多关注炎症和动力问题之间关系的项目的一部分。这个项目的重点是寻找新的生物标志物来评估儿童嗜酸性食管炎。对儿科运动和相关障碍感兴趣的受训者将被鼓励直接参与这些临床研究培训机会。在我的指导下提供有组织的指导，受训人员将精通在儿童中进行运动测试、研究项目的设计和实施、数据分析、演示组织以及手稿准备的技术方面。学员可以参加哈佛公共卫生学院或类似项目的课程，以学习流行病学、生物统计学和临床调查方面的高级教育。在整个培训年中，学员将为学术生涯做好准备。K24奖项将为申请者实现其指导和研究目标提供必要的支持。

This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and mentoring programs at the Center for Motility and Functional Gastrointestinal Disorders at Children's Hospital in Boston. The primary goal for this award is to provide protected time for mentoring in the setting of several ongoing patient-oriented research projects in pediatric motility and related disorders. One of the main objectives is to provide research training and mentorship for young investigators in this field. There are three main projects that are proposed in this application. One focuses on the treatment of non-acid reflux with the use of baclofen, the other on the use of nitric oxide paste to treat obstructive symptoms in patients with a nom-relaxing [sic] internal anal sphincter, and the third is a translational project that's is part of a boarder focus on the relation between inflammation and motility problems. This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved in these clinical research training opportunities. Structured mentoring is made available under my guidance, and trainees will become proficient in the technical aspects of performing motility testing in children, the design and implementation of research projects, analysis of the data, organization for presentation, as well as manuscript preparation. Trainees may enroll in coursework at the Harvard School of Public Health or similar programs to learn advanced education in epidemiology, biostatistics, and clinical investigation. Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals.