Patient Oriented Research in Pediatric Motility and Related Disorders

以患者为中心的小儿运动及相关疾病研究

• 批准号: 8451390
• 负责人: SAMUEL NURKO
• 金额: $ 17.99万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451390
• 关键词: Area; Award; Baclofen; Biological Assay; Biological Markers; Biometry; Boston; Botox; Case-Control Studies; Cerebral Palsy; Characteristics; Child; Childhood; Circular layer of muscularis propria of anal canal; Clinical Research; Clinical Trials; Constipation; Data Analyses; Defecation; Disease; Disease Progression; Disease remission; Dose; Education; Enrollment; Eosinophilic Esophagitis; Epidemiology; Esophageal; Evaluation; Event; Foundations; Frequencies; Functional Gastrointestinal Disorders; Funding; Gastroesophageal reflux disease; Glycerol; Goals; Grant; Headache; Hypotension; IgE; Immunologics; Infant; Inflammation; Learning; Manuscripts; Mediating; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Monitor; Nitric Oxide; Paste substance; Patients; Pediatric Hospitals; Placebos; Preparation; Public Health Schools; Reflux; Research; Research Personnel; Research Project Grants; Research Training; Safety; Secondary to; Structure; Symptoms; Tachycardia; Testing; Time; Training; Tube; base; career; cell motility; clinical efficacy; design; disease diagnosis; gastrointestinal symptom; implementation research; improved; insight; interest; novel; patient oriented research; placebo controlled study; pressure; programs; prospective; rectal

This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and mentoring programs at the Center for Motility and Functional Gastrointestinal Disorders at Children's Hospital in Boston. The primary goal for this award is to provide protected time for mentoring in the setting of several ongoing patient-oriented research projects in pediatric motility and related disorders. One of the main objectives is to provide research training and mentorship for young investigators in this field. There are three main projects that are proposed in this application. One focuses on the treatment of non-acid reflux with the use of baclofen, the other on the use of nitric oxide paste to treat obstructive symptoms in patients with a nom-relaxing [sic] internal anal sphincter, and the third is a translational project that's is part of a boarder focus on the relation between inflammation and motility problems. This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved in these clinical research training opportunities. Structured mentoring is made available under my guidance, and trainees will become proficient in the technical aspects of performing motility testing in children, the design and implementation of research projects, analysis of the data, organization for presentation, as well as manuscript preparation. Trainees may enroll in coursework at the Harvard School of Public Health or similar programs to learn advanced education in epidemiology, biostatistics, and clinical investigation. Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals.

本申请的K24中期职业研究者奖以患者为导向的研究是基于波士顿儿童医院运动和功能性胃肠道疾病中心的研究和指导计划。该奖项的主要目标是在儿科运动和相关疾病的几个正在进行的以患者为导向的研究项目中提供受保护的指导时间。主要目标之一是为这一领域的年轻调查人员提供研究培训和指导。本申请中提出了三个主要项目。一个是用巴氯芬治疗非酸反流，另一个是用一氧化氮糊剂治疗肛门内括约肌非松弛患者的阻塞性症状，第三个是一个翻译项目，它是炎症和动力问题之间关系的一部分。该项目的重点是寻找新的生物标志物，用于评估儿童嗜酸性食管炎。将鼓励对儿科运动和相关疾病感兴趣的学员直接参与这些临床研究培训机会。在我的指导下提供结构化的指导，学员将精通在儿童中进行运动测试的技术方面，研究项目的设计和实施，数据分析，组织演示以及手稿准备。受训者可以参加哈佛公共卫生学院的课程或类似的课程，学习流行病学、生物统计学和临床调查方面的高级教育。在整个培训期间，学员将为学术生涯做好准备。K24奖将为申请人提供必要的支持，以实现他的导师和研究目标。

项目成果

Esophageal impedance monitoring for gastroesophageal reflux.

• DOI: 10.1097/mpg.0b013e3181ffde67
• 发表时间: 2011-02
• 期刊: Journal of pediatric gastroenterology and nutrition
• 影响因子: 2.9
• 作者: Mousa HM;Rosen R;Woodley FW;Orsi M;Armas D;Faure C;Fortunato J;O'connor J;Skaggs B;Nurko S
• 通讯作者: Nurko S

Functional abdominal pain and irritable bowel syndrome in children and adolescents.

儿童和青少年的功能性腹痛和肠易激综合征。

• DOI: 10.2217/thy.11.7
• 发表时间: 2011
• 期刊: Therapy (London, England : 2004)
• 作者: Chiou,Eric;Nurko,Samuel
• 通讯作者: Nurko,Samuel

Relationship between postprandial metabolomics and colon motility in children with constipation.

• DOI: 10.1111/nmo.12086
• 发表时间: 2013-05
• 期刊: Neurogastroenterology and motility
• 影响因子: 3.5
• 作者: Rodriguez L;Roberts LD;LaRosa J;Heinz N;Gerszten R;Nurko S;Goldstein AM
• 通讯作者: Goldstein AM

Validation of a bowel dysfunction instrument for adolescents with spina bifida.

针对患有脊柱裂的青少年的肠道功能障碍仪器的验证。

• DOI: 10.1016/j.jpurol.2015.06.001
• 发表时间: 2015
• 期刊: Journal of pediatric urology
• 影响因子: 2
• 作者: Hubert,Katherine;Sideridis,Georgios;Sherlock,Rebecca;Queally,Jennifer;Rosoklija,Ilina;Kringle,Greta;Johnson,Kathryn;Nurko,Samuel;Bauer,Stuart
• 通讯作者: Bauer,Stuart

Lack of utility of abdominal x-rays in the evaluation of children with constipation: comparison of different scoring methods.

• DOI: 10.1097/mpg.0b013e3181cb4309
• 发表时间: 2010-08
• 期刊: Journal of pediatric gastroenterology and nutrition
• 影响因子: 2.9
• 作者: Pensabene L;Buonomo C;Fishman L;Chitkara D;Nurko S
• 通讯作者: Nurko S