Patient Oriented Research in Pediatric Motility and Related Disorders

本申请K24面向患者研究的职业中期研究者奖是基于波士顿儿童医院运动和功能性胃肠疾病中心的研究和指导项目。该奖项的主要目标是为几个正在进行的儿童运动和相关疾病的以患者为导向的研究项目提供保护时间。主要目标之一是为该领域的年轻研究人员提供研究培训和指导。在此应用程序中提出了三个主要项目。其中一个重点是使用巴氯芬治疗非酸反流，另一个是使用一氧化氮糊剂治疗患有不放松的内肛门括约肌的患者的阻塞性症状，第三个是一个转化项目，是关注炎症和运动问题之间关系的一部分。本项目的重点是寻找新的生物标志物来评估儿童嗜酸性粒细胞性食管炎。对儿童运动及相关疾病感兴趣的学员将被鼓励直接参与这些临床研究培训机会。在我的指导下，对学员进行结构化的指导，熟练掌握对儿童进行运动测试、研究项目的设计与实施、数据分析、组织演示、稿件编写等技术方面的知识。学员可以参加哈佛大学公共卫生学院的课程或类似的项目，学习流行病学、生物统计学和临床调查方面的高级教育。在整个培训期间，学员将为学术生涯做好准备。K24奖将为申请人提供必要的支持，以实现他的指导和研究目标。

This application for a K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and mentoring programs at the Center for Motility and Functional Gastrointestinal Disorders at Children's Hospital in Boston. The primary goal for this award is to provide protected time for mentoring in the setting of several ongoing patient-oriented research projects in pediatric motility and related disorders. One of the main objectives is to provide research training and mentorship for young investigators in this field. There are three main projects that are proposed in this application. One focuses on the treatment of non-acid reflux with the use of baclofen, the other on the use of nitric oxide paste to treat obstructive symptoms in patients with a nom-relaxing [sic] internal anal sphincter, and the third is a translational project that's is part of a boarder focus on the relation between inflammation and motility problems. This project is focused on finding new biomarkers for the evaluation of children with eosinophilic esophagitis. Trainees interested in pediatric motility and related disorders will be encouraged to become directly involved in these clinical research training opportunities. Structured mentoring is made available under my guidance, and trainees will become proficient in the technical aspects of performing motility testing in children, the design and implementation of research projects, analysis of the data, organization for presentation, as well as manuscript preparation. Trainees may enroll in coursework at the Harvard School of Public Health or similar programs to learn advanced education in epidemiology, biostatistics, and clinical investigation. Throughout their training years trainees will be prepared for academic careers. The K24 award will provide with essential support for the applicant to achieve his mentorship and research goals.