AMITRIPTYLINE IN CHILDREN WITH ABDOMINAL PAIN OF NON- ORGANIC ORIGIN

阿米替林治疗非器质性腹痛儿童

• 批准号: 7607261
• 负责人: SAMUEL NURKO
• 金额: $ 0.22万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607261
• 关键词: Abdominal Pain; Amitriptyline; Anxiety; Brain imaging; Child; Computer Retrieval of Information on Scientific Projects Database; Daily; Double-Blind Method; Esthesia; Funding; Future; Grant; Institution; Intestines; Measures; Mental Depression; Monitor; Motor; Pain; Patients; Pharmaceutical Preparations; Phase; Physiological; Questionnaires; Randomized; Research; Research Design; Research Personnel; Resources; Source; Symptoms; Testing; United States National Institutes of Health; Visceral; Week; coping; health related quality of life; image processing; placebo controlled study; psychosocial; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary aim: The main objective of our interventional study is to evaluate the impact of the medication (amitriptyline) on symptoms of patients with abdominal pain of non-organic origin. Secondary aim: To examine the interaction between psychosocial traits (e.g., anxiety, depression, pain coping mechanisms, health-related quality of life) and bowel symptoms and measure the impact of therapy on those variables. Long term objective: We hope to expand the project in the future by evaluating this or other medications on physiologic variables such as visceral sensation, motor function and brain imaging and processing. This is a multi-center, randomized, double-blind placebo controlled study designed to determine if amitriptyline is useful in the treatment of children with functional abdominal pain. The study hypotheses will be tested by monitoring daily symptoms during the treatment phase and by administering questionnaires one week before and one month after initiation of treatment.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 主要目的： 我们的干预性研究的主要目的是评价药物（阿米替林）对非器质性腹痛患者症状的影响。 次要目的： 研究心理社会特征之间的相互作用（例如，焦虑、抑郁、疼痛应对机制、健康相关的生活质量）和肠道症状，并测量治疗对这些变量的影响。 长期目标： 我们希望在未来通过评估这种或其他药物对生理变量（如内脏感觉，运动功能和大脑成像和处理）的影响来扩展该项目。 这是一项多中心、随机、双盲安慰剂对照研究，旨在确定阿米替林是否可用于治疗儿童功能性腹痛。 将通过监测治疗期间的每日症状以及在治疗开始前一周和治疗开始后一个月进行问卷调查来检验研究假设。