3D Real-time imaging system for Subglottic Stenosis and Edema in Neonates

新生儿声门下狭窄和水肿的 3D 实时成像系统

• 批准号: 8441591
• 负责人: Tirunelveli Ramalingam
• 金额: $ 30.85万
• 依托单位: OCT MEDICAL IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-03-15 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8441591
• 关键词: Anatomy; Asia; Bronchoscopy; Businesses; Cardiac; Catheters; Child; Cicatrix; Clinical; Clinical Trials; Critical Illness; Custom; Development; Diagnosis; Diagnostic; Diagnostic Imaging; Disease; Edema; Endoscopes; Endoscopic Surgical Procedures; Epithelial; Epithelium; Evaluation; Event; Excision; Fiber; Gold; Histologic; Histopathology; Hypoxia; Image; Infant; Inflammation; Injury; Intratracheal Intubation; Laryngoscopy; Larynx; Lead; Legal patent; Licensing; Life; Light; Lung; Magnetic Resonance Imaging; Marketing; Medical; Medical Device; Medical Imaging; Modeling; Monitor; Nature; Neonatal; Newborn Infant; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Patients; Physiological; Pilot Projects; Population; Premature Infant; Property; Real-Time Systems; Research Personnel; Resolution; Respiratory distress; Sales; Side; Site; Stenosis; Stress; Subglottis structure; Surface; System; Techniques; Technology; Testing; Time; Tissues; Tracheostomy procedure; Tracheotomy procedure; Trauma; Tube; Ultrasonography; United States National Institutes of Health; Work; base; cost effective; critically ill newborn; endotracheal; experience; flexibility; imaging modality; neonate; nitinol; success; touchscreen

DESCRIPTION (provided by applicant): Major common cause of subglotis is endotracheal intubation during the critical first days of life. In the premature infant and newborn patient, thi condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Further, the tissues of the subglottis are delicate in nature, easily damaged, and rapidly develop edematous changes. These circumstances, when taken together, significantly predispose the subglottis to inflammation, scar formation, and stenosis in the critically ill newborn requiring endotracheal intubation. In the premature infant and newborn patient, this condition may pass undetected or present as a life-threatening and, at worst, a life-ending event. Using several licensed patents, OCT Medical Imaging Inc (OCTMI) proposes to develop an advanced ultrafast compact, cost-effective, touch-screen real-time 3D-functional Fourier domain functional OCT (F- OCT) system. We also develop a Nitionl based fiber microprobes (<0.6mm) that can be slipped into an endoscope or through an endotracheal tube. With this imaging system and probes, we will not only acquire images at near histopathological resolution, but also provide clinically important structural & functional information on the onset and progression of subglottic airway disease in these critically ill patients.

描述（由申请方提供）：声门下炎的主要常见原因是在生命的关键最初几天进行气管插管。在早产儿和新生儿患者中，这种情况可能未被发现或作为危及生命的事件出现，最坏的情况下，是生命终结事件。此外，声门下的组织本质上是脆弱的，容易受损，并且迅速发展水肿变化。这些情况，当考虑在一起时，显着易患炎症，瘢痕形成，并在危重新生儿需要气管插管狭窄声门下。在早产儿和新生儿患者中，这种情况可能未被检测到，或作为危及生命的事件出现，最坏的情况下，是生命终结事件。OCT Medical Imaging Inc（OCTMI）利用多项授权专利，提出开发一种先进的超快紧凑型、成本效益高的触摸屏实时3D功能傅立叶域功能OCT（F-OCT）系统。我们还开发了一种基于Nitionl的光纤微探针（<0.6mm），可以滑入内窥镜或通过气管内导管。有了这个成像系统和探头，我们不仅可以获得接近组织病理学分辨率的图像，而且还可以提供这些危重患者声门下气道疾病发作和进展的临床重要结构和功能信息。