Pelvic Floor Disorders Network

盆底疾病网络

• 批准号: 8495367
• 负责人: CHARLES William NAGER
• 金额: $ 30.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-11 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8495367
• 关键词: Abdomen; Address; Adopted; Anatomy; Anus; Apical; Award; Caring; Clinical Research; Complication; Development; Devices; Discipline of obstetrics; Epidemiology; Evaluation; Excision; Fellowship; Funding; Gynecologist; Health; Health Maintenance Organizations; Hysterectomy; Institution; Institutional Review Boards; Leadership; Master' s Degree; Medical center; Medicine; Menopause; Modeling; Obesity; Operative Surgical Procedures; Outcome Measure; Patients; Pelvic Floor Disorders; Pelvic floor structure; Pelvis; Perioperative; Physicians; Physiology; Population; Procedures; Ptosis; Questionnaires; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Residencies; Robotics; Role; Sexual Health; Site; Staging; Subgroup; Suspension substance; Suspensions; Techniques; Tissues; Training Programs; United States National Institutes of Health; Urodynamics; Urologist; Uterine Prolapse; Uterus; Vagina; Vaginal Hysterectomy; Visit; Woman; Work; cost; cost effectiveness; experience; functional outcomes; health related quality of life; innovation; medical schools; member; multidisciplinary; parity; patient population; primary outcome; programs; randomized trial; research study; skills; statistics; success; tertiary care; trend; urinary

DESCRIPTION (provided by applicant): The objectives and aims of this application are for the San Diego site to continue its work In the Pelvic Floor Disorders Network (PFDN). The unique strength of our application is our proven two site model, which combines the strengths of 7 academic investigators at both a tertiary medical center and a large volume HMO. We would like to provide leadership, continuity, innovation, academic expertise, a captured diverse patient population, and a proven research infrastructure to the network. We have a track-record of being the top 2 recruitment in surgical trials for pelvic floor disorders and we want to continue that into the third cycle of the PFDN. As noted in the RFA," In many cases, clinicians caring for women with pelvic floor disorders have adopted principles of care and surgical techniques before rigorous, objective, controlled evaluation has taken place. New devices and techniques have had a dramatic influence on surgical practice...".Our study addresses this concern. Vaginal mesh is probably the most controversial topic in pelvic floor disorders and a strong argument can be made that the PFDN is the best group to study it. A growing-trend of women is seeking uterine sparing surgery for prolapse and a growing trend of gynecologists and urologists are managing uterine prolapse with vaginal mesh kit procedures. Our proposed randomized trial of uterine sparing, grafted vaginal apical suspension vs. traditional hysterectomy with native tissue suspension addresses the very important question of whether it is necessary to remove the uterus to treat uterine prolapse. This proposed study recognizes the role of new devices and techniques that are changing our care of women with pelvic floor disorders. Our comprehensive outcome measures should allow us to answer whether these new uterine-sparing, apical vaginal procedures are reasonable alternatives to conventional vaginal hysterectomy and native tissue suspension. RELEVANCE: Our site's participation in the next cycle of the PFDN should allow successful network recruitment for surgical trials. Uterine prolapse is a very common pelvic floor disorder and we should determine the best vaginal surgical treatment for this condition. This proposed research study will answer whether uterine - sparing procedures are reasonable alternatives to hysterectomy for this condition.

描述（由申请人提供）：本申请的目标和目的是为了圣地亚哥站点继续其在盆底疾病网络（PFDN）中的工作。我们的应用程序的独特优势是我们经过验证的两个站点模型，它结合了三级医疗中心和大型HMO的7名学术研究人员的优势。我们希望为该网络提供领导力、连续性、创新、学术专长、多样化的患者群体和成熟的研究基础设施。我们在骨盆底疾病的手术试验中一直名列前二我们希望在PFDN的第三个周期中继续这样做。正如RFA所指出的，“在许多情况下，临床医生在进行严格、客观、可控的评估之前，已经采用了护理原则和手术技术。新的设备和技术对外科实践产生了巨大的影响……”我们的研究解决了这个问题。阴道网片可能是骨盆底疾病中最具争议的话题，PFDN是研究它的最佳组，这是一个强有力的论点。越来越多的女性寻求保留子宫脱垂的手术，越来越多的妇科医生和泌尿科医生使用阴道网状物治疗子宫脱垂。我们提出的子宫保留，移植阴道根尖悬吊与传统子宫切除术与天然组织悬吊的随机试验，解决了是否有必要切除子宫治疗子宫脱垂的重要问题。这项拟议的研究认识到新设备和技术的作用，正在改变我们对盆底疾病妇女的护理。我们的综合结果测量应该允许我们回答这些新的保留子宫的根尖阴道手术是否是传统阴道子宫切除术和自然组织悬浮的合理选择。