Pelvic Floor Disorders Network
盆底疾病网络
基本信息
- 批准号:7940284
- 负责人:
- 金额:$ 25.24万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-11 至 2012-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAlabamaBehaviorBladderCaliforniaCaringCitiesClinicCollaborationsCommunitiesEvaluationExpenditureFailureFunctional disorderGeneral PractitionersGoalsGynecologistHealthcareIncontinenceInternationalInvestigationKnowledgeLeadLeadershipMedical centerOperative Surgical ProceduresOutcomePatient RecruitmentsPatientsPelvic Floor DisordersPelvic floor dysfunctionPharmaceutical PreparationsRandomized Clinical TrialsRandomized Controlled Clinical TrialsRandomized Controlled TrialsRecruitment ActivityResearch PersonnelResource AllocationRiskRoleSisterSiteStress Urinary IncontinenceSurveysTechniquesTestingTimeTreatment EfficacyUnited StatesUniversitiesUrethraUrinary IncontinenceUrodynamicsWomanWomen&aposs GroupWorkclinical research sitecostdesignefficacy trialimprovedpressureprotocol developmentskillssuccess
项目摘要
DESCRIPTION (provided by applicant): The objectives and aims of this application are for San Diego to become the first western United States clinical site in the Pelvic Floor Disorders Network (PFDN). The San Diego Clinical Site is a collaboration of three medical centers: 1) the University of California, San Diego (UCSD), 2) Kaiser Permanente, San Diego (Kaiser) and the 3) Naval Medical Center, San Diego (NMCSD). This same collaboration in the Urinary Incontinence Treatment Network (UITN) led all sites in patient recruitment for the UITN SISTEr (Stress Incontinence Surgery Treatment Efficacy) trial. The efficiency of the San Diego Clinical Site's efforts was recognized by the PFDN and we were asked to become a subcontract site for the University of Alabama for the Colpopexy and Reduction Efforts (CARE) study. In the brief nine months available before the CARE study ended, San Diego (UCSD and Kaiser only) recruited 19 patients to CARE. This total was more than all but one center during those nine months. We were the third UITN site to reach recruitment goals in the UlTN's BE-DRI (Behavior Enhances Drug Reduction Incontinence) study. Additionally in the UITN, our site has led efforts in the design, protocol development, and workgroup leadership for the UlTN's current study, TOMUS (Trial Of Mid-Urethral Slings). Urodynamic studies are commonly performed in the United States at an annual cost of approximately 400 million dollars. These urodynamic studies are routine preoperative investigations in most centers that have urodynamic capability, yet we do not have evidence that these tests improve outcomes. Our concept proposal is a randomized trial of preoperative urodynamic studies in women with predominant stress urinary incontinence. The primary aim is to determine if preoperative urodynamic studies improve treatment success rates in all women considered candidates for SUI surgery after an office evaluation. We believe that this proposed urodynamics study requires a multi-center randomized clinical trial and has significant relevance to the appropriate evaluation and care of women with pelvic floor disorders, namely urinary incontinence. The proposed study also has potential significant importance for national health care resource allocation and expenditures. The work that the San Diego investigators have done for the UITN in the last five years to develop standardized, quality urodynamic studies make them the ideal investigators to lead this effort. We believe that the PFDN will benefit greatly by the proven ability of the San Diego Clinical Site's demonstrated energy, skills, and leadership.
描述(由申请人提供):本次申请的目标和目的是圣地亚哥成为美国西部第一个盆底疾病网络(PFDN)的临床站点。圣地亚哥临床中心是三家医疗中心的合作:1)加州大学圣地亚哥分校(UCSD), 2)圣地亚哥凯撒医疗机构(Kaiser Permanente)和3)圣地亚哥海军医疗中心(NMCSD)。尿失禁治疗网络(UITN)的这一合作在UITN姐妹(压力性尿失禁手术治疗疗效)试验的患者招募中处于领先地位。圣地亚哥临床站点的工作效率得到了PFDN的认可,我们被要求成为阿拉巴马大学Colpopexy和Reduction efforts (CARE)研究的分包站点。在CARE研究结束前的短短9个月里,圣地亚哥(仅UCSD和Kaiser)招募了19名患者加入CARE。在这9个月里,这个总数超过了除了一个中心以外的所有中心。我们是第三个在UlTN的BE-DRI(行为增强药物减少失禁)研究中达到招募目标的unitn站点。此外,在utn,我们的站点在UlTN当前的研究——TOMUS(中尿道吊带试验)的设计、协议开发和工作组领导方面发挥了主导作用。尿动力学研究通常在美国进行,每年花费约4亿美元。在大多数具有尿动力学能力的中心,这些尿动力学研究是常规的术前检查,但我们没有证据表明这些检查可以改善预后。我们的概念建议是一项术前尿动力学研究的随机试验,研究女性主要的压力性尿失禁。主要目的是确定在办公室评估后,术前尿动力学研究是否能提高所有女性SUI手术候选人的治疗成功率。我们认为,这项尿动力学研究需要一项多中心随机临床试验,并且与盆底疾病(即尿失禁)妇女的适当评估和护理具有重要意义。拟议的研究对国家卫生保健资源分配和支出也具有潜在的重要意义。圣地亚哥研究人员在过去五年中为联合国泌尿系统研究所所做的标准化、高质量的泌尿动力学研究使他们成为领导这项工作的理想研究人员。我们相信,圣地亚哥临床中心的能力、技能和领导能力将使PFDN受益匪浅。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHARLES William NAGER其他文献
CHARLES William NAGER的其他文献
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The Urethral Sleeve Sensor_A Novel Method of Measuring Urethral Pressure
尿道套传感器_测量尿道压力的新方法
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8307322 - 财政年份:2011
- 资助金额:
$ 25.24万 - 项目类别:
The Urethral Sleeve Sensor_A Novel Method of Measuring Urethral Pressure
尿道套传感器_测量尿道压力的新方法
- 批准号:
8029451 - 财政年份:2011
- 资助金额:
$ 25.24万 - 项目类别:
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