Patient-oriented and effectiveness research in chronic liver disease

慢性肝病的以患者为中心的有效性研究

基本信息

批准号：
8165204
负责人：
W. Ray KIM
金额：
$ 12.68万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-02 至 2017-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8165204
关键词：
Achievement Age-Years American Area Arginine Authorship Award Bioinformatics Calcineurin inhibitor Cause of Death Center for Translational Science Activities Cessation of life Chronic Kidney Failure Chronic viral hepatitis Clinic Country Creatinine Data Data Analyses Data Collection Development Diagnosis Education Effectiveness Ensure Epidemiologic Studies Epidemiology Exploratory/Developmental Grant Faculty Fellowship Funding Future Genetic Goals Grant Health Health Services Research Hepatitis B Immunosuppressive Agents Indium Individual Institution International Kidney Failure Laboratory Research Lead Length Light Liver Liver diseases Medical Students Medicine Mentors Methods Modeling Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Nephrotoxic Nitric Oxide Observational Study Outcome Paper Patient Care Patients Phase Play Postoperative Period Prevalence Prevention Process Publications Quality of life Registries Renal function Research Research Activity Research Design Research Methodology Research Personnel Research Project Grants Residencies Risk Role San Francisco Serum Site Societies Staging Statistical Models Testing Time Training Translational Research Transplant Recipients Transplantation United States United States National Institutes of Health Universities Validation Work adverse outcome aged base career career development chronic liver disease cohort college comparative effectiveness design effectiveness research experience genetic epidemiology innovation insight interest liver transplantation member mortality nephrotoxicity novel patient oriented patient oriented research pilot trial premature prevent prognostic programs randomized trial skills success tool

项目摘要

DESCRIPTION (provided by applicant): This is a K-24 ('Mid-career investigator Award in Patient-Oriented Research') application by W. Ray Kim, MD entitled, "Patient-Oriented and Effectiveness Research in Chronic Liver Disease." Chronic liver disease has a widespread health burden in the United States. It is the fourth most common cause of death in Americans aged between 41 and 50 years of age, indicating that it causes many premature deaths. Dr. Kim is one of the most productive researchers in patient-oriented research in liver disease. The most widely recognized achievement in Dr. Kim's research is the development, validation and refinement of the MELD score. He is also well known for his expertise in epidemiology, diagnosis, treatment and prevention of chronic viral hepatitis including hepatitis B and C. Since he joined the faculty at Mayo Clinic College of Medicine, he has led numerous research projects working with young investigators, many of whom continue their endeavors in academic medicine. He also organized educational programs in patient- oriented research methods on behalf of international academic societies. Dr. Kim's research program to date has been supported by three federal grants. The first grant continues to evaluate the MELD score and investigates chronic kidney disease in the setting of liver transplant candidates and recipients (R01). The second grant constitutes a pilot trial to test the hypothesis that nitric oxide plays an important role in post-transplant chronic kidney disease (R21). The third grant is a multicenter network to conduct research in hepatitis B (U01). In this application, Dr. Kim is requesting support of his time to mentor junior faculty members, fellows, residents and medical students working in patient oriented research. These mentees are mostly trainees at Mayo Clinic, but given the international background and reputation, selected individuals from institutions outside the US will also be included. Secondarily, the support will be used to enhance and supplement Dr. Kim's research expertise, specifically in the area of comparative effectiveness research and genetic epidemiology and bioinformatics. His mentoring plans include (1) formal methods training in patient-oriented research through the Center for Translational Science Activities (CTSA) and other didactic material at Mayo Clinic, (2) hands-on guidance for research experience in conducting individual projects, which includes study design, data collection and analysis, presentation and publication, and application for funding; and (3) one-on-one mentoring to accomplish career milestones in research from residency electives to fellowship training to junior faculty development. Strong Divisional and Institutional support exists to ensure the success of the mentoring program. PUBLIC HEALTH RELEVANCE: Chronic liver disease is one of the most common causes of premature death in Ameri- cans. Dr. Kim has been one of the most productive researchers in patient-oriented re- search in chronic liver disease. In this application, Dr. Kim is requesting support of his time to mentor junior faculty members, fellows, residents and medical students working in patient oriented research. The grant will also enhance and supplement Dr. Kim's re- search expertise, specifically in the area of comparative effectiveness research and ge- netic epidemiology and bioinformatics.

描述（由申请人提供）：这是K-24（“以患者为导向研究的中期研究者奖”），由MD W. Ray Kim申请，标题为“慢性肝病中以患者为导向和有效性研究”。慢性肝病在美国具有广泛的健康负担。它是41至50岁的美国人中第四大死亡原因，表明它会导致许多过早死亡。 Kim博士是肝病研究中最有效的研究人员之一。 Kim博士的研究中最广泛认可的成就是MELD分数的开发，验证和完善。他还以在流行病学，诊断，治疗和预防慢性病毒肝炎（包括丙型肝炎）方面的专业知识而闻名。他加入了梅奥临床医学学院的教职员工，他领导了许多与年轻研究人员一起工作的研究项目，其中许多人继续从事学术医学的工作。他还代表国际学术社会组织了以患者为导向的研究方法的教育计划。迄今为止，金博士的研究计划得到了三项联邦赠款的支持。第一份赠款继续评估MELD评分，并在肝移植候选者和接受者的情况下研究慢性肾脏疾病（R01）。第二笔赠款构成了一项试验试验，以检验一氧化氮在移植后慢性肾脏疾病（R21）中起重要作用的假设。第三笔赠款是一个多中心网络，用于进行乙型肝炎（U01）研究。在此申请中，金博士要求支持他的时间指导初级教职员工，研究员，居民和医学生从事以患者为导向的研究。这些受训者主要是梅奥诊所的学员，但是鉴于国际背景和声誉，也将包括来自美国以外机构的精选个人。其次，该支持将用于增强和补充Kim博士的研究专业知识，特别是在比较有效性研究和遗传流行病学和生物信息学领域。他的指导计划包括（1）通过转化科学活动中心（CTSA）（CTSA）和Mayo Clinic的其他教学材料的正式方法培训，（2）进行单个项目的研究经验指南，其中包括研究设计，数据收集和分析，演示和分析，演示和出版，以及资金的应用；（3）一对一的指导，以实现从居住选修课到奖学金培训到初级教师发展的研究中的职业里程碑。存在强大的分区和机构支持，以确保指导计划的成功。公共卫生相关性：慢性肝病是美国早期死亡最常见的原因之一。 Kim博士一直是慢性肝病中最有生产力的研究人员之一。在此申请中，金博士要求支持他的时间指导初级教职员工，研究员，居民和医学生从事以患者为导向的研究。该赠款还将增强和补充金博士的研究专业知识，特别是在比较有效性研究和网络流行病学和生物信息学领域。