Strategies for Improved Shock Wave Lithotripsy

改进冲击波碎石术的策略

• 批准号: 8291366
• 负责人: James Alexander McAteer
• 金额: $ 146.27万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-05-10 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8291366
• 关键词: Acoustics; Acute; Adverse effects; Calculi; Chronic; Clinical; Coupling; Diabetes Mellitus; Excision; Feedback; Goals; Health; Hemorrhage; Injury; Interdisciplinary Study; Kidney; Kidney Calculi; Link; Lithotripsy; Long-Term Effects; Methods; Modeling; Monitor; Obesity; Organ; Outcome; Patients; Play; Property; Research; Role; Safety; Shock; Site; Structure; Techniques; Technology; Tissues; Trauma; Treatment Protocols; Ureter; Urinary Calculi; Work; common treatment; improved; pressure; programs; trend

DESCRIPTION, OVERALL (provided by applicant): We propose a coordinated, highly interactive multidisciplinary collaboration between four Projects and two Cores with the main goal of making shock wave lithotripsy (SWL) safe and effective for all patients. In this work we will: * Determine the chronic effects of SWL on the kidney-the long-term effects on renal structure and function that follow induction of acute damage during a treatment session * Determine if lithotripsy induces new-onset diabetes Develop treatment protocols that protect patients from SWL adverse effects * Determine the properties of SWs at their site of action in the kidney and proximal ureter * Increase the efficiency of SWL by improving the acoustic coupling between the lithotripter and the patient * Devise treatment protocols that improve SWL outcomes for obese patients * Determine the treatment threshold for SWL injury and develop a method to monitor onset of conditions that are damaging to the kidney * Evaluate the efficacy and safety of a new trend-low-pressure wide-focal-zone-in clinical lithotripter technology * Develop acoustic monitoring and feedback techniques to improve the targeting and firing of lithotripters to eliminate the delivery of SWs that miss the stone, and to determine when the stone has broken to completion and the session can be ended * Determine the mechanism by which cavitation within a vessel causes hemorrhage * Develop numerical models to understand the role of cavitation and non-cavitational mechanisms in causing tissue damage

概述（由申请人提供）：我们建议在四个项目和两个核心之间进行协调，高度互动的多学科合作，主要目标是使冲击波碎石（SWL）对所有患者安全有效。在这项工作中，我们将：