Innate immunity in food allergy

食物过敏中的先天免疫

• 批准号: 9796540
• 负责人: Maria CECILIA BERIN
• 金额: $ 1.41万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796540
• 关键词: Allergy to peanuts; Biomedical Research; Child; Clinical; Communication; Complement; Dendritic Cells; Development; Development Plans; Doctor of Philosophy; Food Hypersensitivity; Goals; Grant; Immune; Immune response; Immunology; Mentorship; Mind; Myelogenous; Natural Immunity; Oral; Phenotype; Rewards; STEM field; Science; Technical Expertise; Technology; Training; Underrepresented Minority; Work; Writing; base; career; career development; clinical heterogeneity; cohort; minority children; minority student; monocyte; parent grant; response; skill acquisition; skills

PROJECT SUMMARY This Diversity Supplement will support the career development of Justine Noel who will perform PhD thesis studies under the mentorship of Cecilia Berin. The parent grant (U19 grant AI136053, “Immune Basis & Clinical Implications of Threshold-Based Phenotypes of Peanut Allergy”) will examine the immune basis of clinical heterogeneity of peanut allergy, with an emphasis on the adaptive and effector immune responses to peanut. In this supplement proposal, Ms. Noel will study innate immunity and focus on myeloid (monocyte and dendritic cell) responses to peanut within the same cohort described in the parent grant. The candidate career development plan will include intensive training in oral and written communication, grant writing, technical skill development with CyTOF-based technologies, and didactic training in computational immunology. Development of mentorship skills is also a component of the career development plan, and fits with the long- term goals of the candidate to work with children to show minority students that science is fun and rewarding, and stimulate young minds from all backgrounds to enter the STEM field.

项目摘要 这个多元化补充将支持贾斯汀诺埃尔谁将执行博士论文的职业发展 在塞西莉亚·贝林的指导下学习。母基金（U19基金AI136053，“免疫基础和临床 花生过敏症的遗传表型的意义”）将检查临床免疫基础， 花生过敏的异质性，强调对花生的适应性和效应免疫应答。 在这个补充建议中，诺埃尔女士将研究先天免疫，重点是骨髓（单核细胞和树突状细胞 细胞）对花生的反应在父母补助金中描述的同一队列中。候选人职业生涯 发展计划将包括口头和书面沟通，赠款写作，技术技能密集培训 开发基于CyTOF的技术，以及计算免疫学的教学培训。 发展辅导技能也是职业发展计划的一个组成部分，符合长期的 候选人的学期目标是与儿童一起工作，向少数民族学生展示科学是有趣和有益的， 并激励来自各种背景的年轻人进入STEM领域。