Innate immunity in food allergy

食物过敏中的先天免疫

• 批准号: 9796540
• 负责人: Maria CECILIA BERIN
• 金额: $ 1.41万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-01-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9796540
• 关键词: Allergy to peanuts; Biomedical Research; Child; Clinical; Communication; Complement; Dendritic Cells; Development; Development Plans; Doctor of Philosophy; Food Hypersensitivity; Goals; Grant; Immune; Immune response; Immunology; Mentorship; Mind; Myelogenous; Natural Immunity; Oral; Phenotype; Rewards; STEM field; Science; Technical Expertise; Technology; Training; Underrepresented Minority; Work; Writing; base; career; career development; clinical heterogeneity; cohort; minority children; minority student; monocyte; parent grant; response; skill acquisition; skills

PROJECT SUMMARY This Diversity Supplement will support the career development of Justine Noel who will perform PhD thesis studies under the mentorship of Cecilia Berin. The parent grant (U19 grant AI136053, “Immune Basis & Clinical Implications of Threshold-Based Phenotypes of Peanut Allergy”) will examine the immune basis of clinical heterogeneity of peanut allergy, with an emphasis on the adaptive and effector immune responses to peanut. In this supplement proposal, Ms. Noel will study innate immunity and focus on myeloid (monocyte and dendritic cell) responses to peanut within the same cohort described in the parent grant. The candidate career development plan will include intensive training in oral and written communication, grant writing, technical skill development with CyTOF-based technologies, and didactic training in computational immunology. Development of mentorship skills is also a component of the career development plan, and fits with the long- term goals of the candidate to work with children to show minority students that science is fun and rewarding, and stimulate young minds from all backgrounds to enter the STEM field.

项目概要 该多样性补充品将支持贾斯汀·诺埃尔（Justine Noel）的职业发展，她将完成博士论文 在塞西莉亚·贝林 (Cecilia Berin) 的指导下学习。家长资助（U19 资助 AI136053，“免疫基础与临床 基于阈值的花生过敏表型的影响”）将检查临床过敏的免疫基础 花生过敏的异质性，重点是对花生的适应性和效应免疫反应。 在这个补充提案中，Noel女士将研究先天免疫并重点关注骨髓（单核细胞和树突状细胞） 细胞）对父母资助中描述的同一队列中的花生的反应。候选人的职业生涯 发展计划将包括口头和书面沟通、资助写作、技术技能方面的强化培训 基于 CyTOF 的技术的开发以及计算免疫学的教学培训。 指导技能的发展也是职业发展计划的一部分，并且符合长期目标。 候选人的学期目标是与儿童一起向少数族裔学生展示科学是有趣且有益的， 并激励来自不同背景的年轻人进入 STEM 领域。