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The Jackson Laboratory's Workshop on Long-Read Genomic Technologies

杰克逊实验室长读基因组技术研讨会

基本信息

批准号：
9792774
负责人：
Chia-Lin Wei
金额：
$ 5.79万
依托单位：
JACKSON LABORATORY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-12 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9792774
关键词：
Address Adopted Adoption Algorithms Automobile Driving Awareness Bioinformatics Biological Collaborations Communicable Diseases Communities Complex Computational Biology Computer Analysis DNA Modification Process DNA sequencing Data Data Analyses Data Science Detection Development Disease Education Educational process of instructing Educational workshop Environment Epigenetic Process Explosion Faculty Fellowship Fostering Gender Generations Genome Genome Mappings Genomic medicine Genomics Goals Group Meetings Health Human Human Genome Industrialization Knowledge Laboratories Learning Length Link Malignant Neoplasms Microfluidics Minority Groups Molecular Biology Muscular Dystrophies Neurodegenerative Disorders Nucleic acid sequencing Optics Participant Positioning Attribute Postdoctoral Fellow Process Protein Isoforms Protocols documentation RNA Repetitive Sequence Research Research Personnel Resolution Science of genetics Scientist Structure Talents Technology The Jackson Laboratory Time Training Transcript Underrepresented Minority Variant Woman Work base career cost design experience genetic variant graduate student improved innovation lectures mammalian genome microbiome nanopore next generation programs recruit sequencing platform single molecule skills symposium technology development tool web site

项目摘要

PROJECT SUMMARY Long-read genomic technologies have identified new genomic causes of diseases, such as cancers, infectious diseases, neurodegenerative diseases, muscular dystrophy, and other conditions, due to its ability to more accurately identify structural variants and sequence through repetitive regions of the genome compared to short- read sequencing. This is despite the fact that long-read sequencing technology is fairly new and sparsely used in the research community. Thus, there is significant opportunity to understand more about the human genome and health and disease via the widespread adoption of long-read technologies. For greater adoption, the field will significantly benefit from a workshop that covers the pros and cons of the existing long-read platforms, how they are currently applied by the scientific community to answer research questions, and includes hands-on tutorials covering the technical execution of these protocols. Therefore, we propose to host an annual 4-day workshop on long-read sequencing technologies at The Jackson Laboratory for Genomic Medicine. We will leverage our experience from a successful pilot workshop on long-read sequencing in 2018, and we will deliver two days of lectures from field leaders who are using these technologies to answer key scientific questions and two days of hands-on technical experimental and computational tutorials focused on data generation and analysis. We will do this through the following 3 aims: 1) To develop and deliver a 4-day workshop to train young scientists on long-read genomic technologies that will include hands-on wet bench and bioinformatics tutorials, and lectures led by technology developers and expert users; 2) To create an environment that will expand the field of long-read sequencing by fostering idea generation, discussion, and collaboration to yield new discoveries, better applications, and increase technology development; 3) To promote diversity in culturing talents in long- read genomic technology development. Participants will leave this workshop with an in-depth understanding of the benefits and challenges of various long-read sequencing platforms, when and how best to apply them, and the current state of genomic research with long-read sequencing technologies. This will, in turn, encourage the appropriate use of long-read sequencing in genomics project, leading to new discoveries that will help understand and improve human health.

项目总结