Epoch Telemetry System for Long-Term Monitoring of Biopotentials

描述(由申请人提供)：Epoch遥测系统用于长期监测生物电势摘要Epoch是一种无线、多通道生物电势记录系统，专为第一阶段和第二阶段开发的人类疾病的小动物转换研究模型而设计。从疾病的动物模型获得长期连续记录是旨在开发新的治疗衰弱疾病的方法的转换研究的关键组成部分，如癫痫、心脏病、脑瘤、创伤性脑损伤和肥胖。许多未成熟的和成年的啮齿动物模型最近被开发出来，它们可以替代人类EPitel Epoch无线6通道生物电位记录系统在儿童和成年人群中进行性疾病的表现。虽然可以定期(即，在未成熟的啮齿动物中，每一次会议的时间为几分钟到几个小时)获得生物电势的捆绑(即“有线”)记录，但这些记录存在与大鼠和小鼠的小尺寸有关的问题。成年大鼠可以使用拴系或遥测记录系统一次获得数周或数月的记录；然而，这两种系统都有局限性。动物越年轻或越小，就越难获得足够的录音，而且几乎不可能获得长期、连续的录音--特别是在老鼠身上。一种无线、多模式、多通道的长期记录生物素材的解决方案 在MICE中还没有上市。埃皮特尔将在IIb阶段通过广泛扩展Epoch系统的单峰电生理能力来满足这一需求，以包括多模式换能器。该项目有3个主要目标：1)开发心脏应用的无线血压和压力-容量传感器，2)为我们的客户提供以立体定向精确定位脑深部结构的多个电极的能力，以及3)能够在一个笼子里同时记录多达4只动物。Epoch是唯一一种无线系统，不仅可以对成年啮齿动物，而且还可以对体重仅为6克的新生动物进行长达6个通道的生物电势记录。大纪元记录系统的基本原理是电容耦合技术。遥测单元的小尺寸(&lt；1g)和低轮廓(&lt；1cc)将允许 可同时记录大鼠或小鼠的大脑皮质和深部的电生理、体温、血压和压力-容量，直接来自左心室，不间断记录多达6个月的颅内压、心电图、肌电和视频记录。研究人员的长期目标是能够在翻译研究中使用大纪元系统，为进行性人类疾病的动物模型开发新的治疗方法。Epoch是唯一一个能够从成年大鼠和小鼠以及新生动物(P6大鼠；P8小鼠)持续记录生物电势的系统，以提供关于疾病进展性质的完整报告，这对于将潜在的治疗方法转化为临床非常重要。大纪元发射器的简单性使开发复杂的、全仪器的人类疾病小动物模型变得更容易。

DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Epoch" is a wireless, multi- channel biopotential recording system designed for small animal translational research models of human disease developed in Phase I and II. Obtaining long- term continuous recordings from animal models of disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epilepsy, heart disease, brain tumor, traumatic brain injury, and obesity. Many immature- and adult-rodent models have recently been developed that are surrogates for human Epitel Epoch Wireless 6 Channel Biopotential Recording System manifestations of progressive disease in the pediatric and adult populations. While tethered (i.e., "wired") recordings of biopotentials can be obtained periodically (i.e., for minutes to a few hours per session in immature rodents), these recordings have problems associated with the small size of rats and mice. Recordings can be obtained for weeks or months at a time from adult rats with either tethered or telemetric recording systems; however, both of these systems have limitations. The younger or smaller the animal, the more difficult it is to obtain adequate recordings, and it is nearly impossible to obtain prolonged, continuous recordings - especially in mice. A wireless, multi- modal, multi-channel solution for recording biopotentials for long periods in mice has not yet been made available in the marketplace. Epitel will address this need in Phase IIb by broadly expanding the unimodal electrophysiology capabilities of the Epoch system to include multimodal transducers. The project has 3 main goals: 1) to develop wireless blood pressure and pressure-volume transducers for cardiac applications, 2) to provide our customers the ability to implant multiple electrodes targeting deep brain structures with stereotactic precision, and 3) to enable simultaneous recording from up to four animals in a single cage. Epoch is the only wireless system able to make up to 6 channels of biopotential recordings in not only adult rodents, but also neonatal animals that weigh as little as 6 grams. The fundamental principle of the Epoch recording system is that the capacitive- coupled technology. The small size (<1 g) and low profile (<1 cc) of the telemetry unit will allow multiple rats or mice to be recorded simultaneously, enabling continuous cortical and deep brain electrophysiology, temperature, blood pressure and pressure-volume directly from the left ventricle, intracranial pressure, electrocardiogram, electromyogram, and video recordings uninterrupted for up to 6 months. The long-term goal is for researchers to be able to use the Epoch system in translational research to develop new therapies for animal models of progressive human disease. Epoch is the only system capable of recording biopotentials from adult rats and mice and neonatal animals (P6 rat; P8 mouse) continuously through weaning into adulthood to provide a full report of the progressive nature of disease, which is important for translation of a potential therapy to the clinic. The simplicity of the Epoch transmitter makes it easier to develop sophisticated, fully instrumented small animal models of human disease.