Epoch Telemetry System for Long-Term Monitoring of Biopotentials

用于长期监测生物电势的 Epoch 遥测系统

• 批准号: 8130392
• 负责人: F. Edward DUDEK
• 金额: $ 59.74万
• 依托单位: EPITEL, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-22 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130392
• 关键词: Adult; Age; Animal Disease Models; Animal Model; Animals; Applications Grants; Brain Injuries; Cephalic; Child; Childhood; Chronic; Computer software; Coupled; Data; Data Analyses; Development; Devices; Disease; Electrocardiogram; Electroencephalogram; Electronics; Epilepsy; Event; Genetic; Goals; Hour; Housing; Human; Implant; Individual; International; Life; Light; Marketing; Monitor; Mus; Neonatal; Pharmacologic Substance; Phase; Population; Predisposition; Rattus; Records; Reliance; Research Personnel; Rodent; Rodent Model; Seizures; Shapes; Solutions; System; Technology; Telemetry; Temperature; Testing; Time; Translational Research; Video Recording; Weaning; Wireless Technology; Work; base; cranium; data acquisition; density; design; digital; human disease; juvenile animal; neonate; nervous system disorder; postnatal; pre-clinical; programs; pup; research study; sleep abnormalities; symposium; therapy development; tool

DESCRIPTION (provided by applicant): Epoch Telemetry System for Long-Term Monitoring of Biopotentials ABSTRACT Neonatal and childhood seizures can increase an individual's susceptibility for developing epilepsy later in life. Obtaining long-term continuous recordings of electrical events, such as the electroencephalogram (EEG), from animal models of neurological disease is a critical component of translational research aimed at developing new therapies for debilitating disorders, such as epilepsy. Many immature- and adult-rodent models have recently been developed that are surrogates for human manifestations of seizures in the pediatric and adult populations. While tethered (i.e., "wired") recordings of the EEG can be obtained periodically (i.e., for minutes to a few hours per session in rodent pups) these recordings have problems associated with the small size of rodent pups and their reliance upon the dam early in life up to weaning at postnatal day 21 (P21) in rats. Likewise, EEG recordings can be obtained for weeks or months at a time from adult rats with either tethered or telemetric (i.e., "wireless") recording systems; however, both of these systems have problems. The younger the animal, the more difficult it is to obtain adequate recordings, and it is nearly impossible to obtain continuous, uninterrupted recordings. The fundamental principle of the Epoch recording system is that the capacitive-coupled technology combined with the small shape and low profile of the telemetry unit will allow multiple rats or mice to be recorded simultaneously, enabling continuous EEG, cranial temperature, and video recordings. In the Phase I program, Epitel, Inc., developed a small (<1 cc, <1 g) wireless device that enables uninterrupted, EEG recordings from up to four EEG channels in rats age P7 and mice age P12 through weaning and adulthood (i.e., continuously for many months at a time) that is the basis of the Epoch recording system. The long-term goal is for researchers to be able to use the Epoch system in translational research to develop new therapies for different types of animal models of acquired and genetic pediatric epilepsy and ultimately, other neonatal- and adult-rodent models of human disease. The ability to obtain long-term continuous recordings should facilitate answering the question of how and when to treat seizures in neonates, children, and adults, potentially blocking the development of chronic epilepsy after brain injury. PUBLIC HEALTH RELEVANCE: This grant application aims to commercialize a new miniature telemetry system for rat and mouse pups and adults that should facilitate translational research on animal models of neonatal, childhood, and adult seizures. The device will enable uninterrupted EEG recordings from at least postnatal day 7 (rats) and postnatal day 12 (mice) through weaning and into adulthood, providing a complete record of the animal's seizures. The long- term goal is to develop a pre-clinical tool to develop therapies against human seizures and ultimately, other rodent models of human disease.

描述（由申请人提供）： 摘要新生儿和儿童期癫痫发作会增加个体在以后生活中发展为癫痫的易感性。从神经系统疾病的动物模型中获得长期连续的电事件记录，如脑电图（EEG），是旨在开发癫痫等衰弱性疾病新疗法的转化研究的关键组成部分。最近开发了许多未成熟和成年啮齿动物模型，这些模型是儿童和成人人群中癫痫发作的人类表现的替代品。在系留时（即，“有线”）记录的EEG可以周期性地获得（即，在啮齿类幼鼠中，每次数分钟至数小时），这些记录存在与啮齿类幼鼠的小尺寸以及它们在生命早期直至大鼠出生后第21天（P21）断奶时对母鼠的依赖相关的问题。同样，EEG记录可以从具有栓系或遥测（即，“无线”）记录系统;然而，这两种系统都有问题。动物越年轻，获得足够的记录就越困难，几乎不可能获得连续、不间断的记录。Epoch记录系统的基本原理是，电容耦合技术与遥测单元的小形状和低轮廓相结合，将允许同时记录多只大鼠或小鼠，从而实现连续的EEG、颅温和视频记录。在第一阶段计划中，Epitel公司，开发了一种小型（<1 cc，<1 g）无线设备，其能够在P7年龄的大鼠和P12年龄的小鼠中从断奶到成年（即，一次连续几个月），这是时代记录系统的基础。长期目标是让研究人员能够在转化研究中使用Epoch系统，为获得性和遗传性儿科癫痫的不同类型动物模型开发新疗法，并最终开发其他新生儿和成年啮齿动物人类疾病模型。获得长期连续记录的能力应有助于回答如何以及何时治疗新生儿，儿童和成人癫痫发作的问题，可能会阻止脑损伤后慢性癫痫的发展。 公共卫生相关性： 这项拨款申请旨在将一种新的用于大鼠和小鼠幼崽和成年人的微型遥测系统商业化，这将有助于新生儿，儿童和成年癫痫发作动物模型的转化研究。该设备将能够从出生后至少第7天（大鼠）和出生后第12天（小鼠）到断奶和成年期进行不间断的EEG记录，提供动物癫痫发作的完整记录。长期目标是开发一种临床前工具，以开发针对人类癫痫发作的治疗方法，并最终开发其他人类疾病的啮齿动物模型。