Chimpanzee Biomedical Research Resource

描述(由申请人提供)：这是德克萨斯州巴斯特罗普的德克萨斯大学MD安德森癌症中心的米歇尔·E·基林比较医学和研究中心(KCCMR)支持“黑猩猩生物医学研究资源”(CBRR)的合作协议的竞争性续签申请。CBRR是一个全国性的研究资源，有159只黑猩猩居住在KCCMR的黑猩猩收容所里。CBRR是世界上仅有的四个能够对该物种进行生物医学研究的研究资源之一。在过去的35年里，CBRR开发了高度专业化的住房设施、实验室、管理技术和工作人员，这些都是养护黑猩猩和使用这一重要模式进行研究所必需的。CBRR的主要目标继续侧重于群体护理和维护，为需要接触黑猩猩的研究人员提供进行研究所需的基础设施，并开展研究以提高黑猩猩的研究价值。在目前的资助期间，我们开发了一个信息网站，帮助科学家评估黑猩猩是否适合作为他们研究的相关模型，并向公众宣传黑猩猩的价值。我们计划继续通过黑猩猩实验工具和实验室参考价值登记处提供黑猩猩来源的细胞系、抗体和其他生物材料。CBRR被组织为三个功能核心，包括资源管理核心、行为管理核心和资源相关研究核心。CBRR支持的研究将继续强调黑猩猩免疫系统的特征，以及通过行为管理核心进行的众多合作行为研究。这些研究包括对经过训练自愿配合研究程序的黑猩猩与必须麻醉的未经训练的黑猩猩进行研究操纵的生理学和免疫学后果的研究。CBRR将继续保持其在训练黑猩猩自愿参与研究和临床操作方面的领导作用，使用积极强化技术。从这个支持期开始，我们计划使用G-MARC对CBRR中的所有黑猩猩进行分类，如RFA-RR-10-008中所述。通过扩大和改善CBRR资源的可获得性，开展与资源相关的研究，并控制成本，CBRR将继续提供极其重要的、高度专业化的研究资源，以满足人类的健康需求。

DESCRIPTION (provided by applicant): This is a competing renewal application of a cooperative agreement supporting the "Chimpanzee Biomedical Research Resource" (CBRR) at the Michale E. Keeling Center for Comparative Medicine and Research (KCCMR) of The University of Texas MD Anderson Cancer Center in Bastrop, TX. The CBRR is a national research resource of 159 chimpanzees housed within the chimpanzee housing complex of the KCCMR. The CBRR is one of only four research resources in the world capable of conducting biomedical research in this species. Over the past 35 years, the CBRR has developed the highly specialized housing facilities, laboratories, management techniques and staff essential for maintaining chimpanzees and conducting research using this important model. The CBRR's primary objectives continue to focus on colony care and maintenance, provision of the infrastructure needed to conduct studies for investigators who need to access chimpanzees, and conducting studies to enhance the research value of chimpanzees. During the current funding period, we developed an informational website to help scientists assess the suitability of chimpanzees as relevant models for their studies and inform the public of the value of chimpanzees. We plan to continue to make available chimpanzee-derived cell lines, antibodies and other biological materials through the Chimpanzee Experimental Tools and Laboratory Reference Value Registry. The CBRR is organized into three functional cores that include the Resource Management Core, the Behavioral Management Core, and the Resource-related Research Core. Studies supported by the CBRR will continue to emphasize the characterization of the chimpanzee immune system and the numerous collaborative behavioral studies through the Behavioral Management Core. These include studies of the physiologic and immunologic consequences of research manipulations on chimpanzees trained to voluntarily cooperate with research procedures compared to untrained chimpanzees that must be anesthetized. The CBRR will continue to maintain its leadership role in the training of chimpanzees to voluntarily participate in research and clinical manipulations using positive reinforcement techniques. Beginning with this period of support, we plan to categorize all chimpanzees within the CBRR using the G-MARC as described in the RFA-RR-10-008. By expanding and improving the availability of CBRR resources, conducting resource-related research, and containing costs, the CBRR will continue to provide a critically important, highly specialized, research resource that addresses human health needs.