ASM Conference on Polymicrobial Infections

 描述(由申请人提供)：本申请寻求对一个跨学科会议的支持，该会议致力于研究和探索与多菌感染有关的共同主题。这是一次新的会议，由ASM会议委员会通过竞争性申请程序批准。会议的主要目标是：1)促进关于不同类型多微生物感染的最新研究的信息交流；2)促进学术和私营部门科学家在医学、牙科和兽医发病机制学科方面的互动和合作；3)提供 一个论坛，供来自不同研究背景和职业阶段的研究人员探索他们研究中的共同主题。发病机制研究的基本原理在150多年前的科赫公设中得到阐明，并在25年前的所谓“分子科赫公设”中得到重申，并涉及到对纯培养中微生物的研究，以最大限度地减少独立变量。然而，随着追踪感染流行病学的更敏感和更复杂的方法的获得和应用日益增多，人们现在越来越认识到，大多数感染涉及同一宿主内多种病原体的相互作用。在许多情况下，不同微生物之间的相互作用可以深刻地影响感染的过程、严重性和可治性。认识到多菌感染的潜在影响，美国国立卫生研究院发布了几个不同的项目邀请函，以解决这些主题，这一领域的研究人员和工作出现了爆炸性增长。然而，除了在ASM大会内举办了一些研讨会，以及由国立卫生研究院主办的几个小型研讨会外，还没有专门讨论这一主题的会议。因此，这次会议跨越了多个学科和研究领域，为交流和发展思想提供了一个重要而难得的机会。

 DESCRIPTION (provided by the applicant): This application seeks support for an interdisciplinary conference devoted to research and exploring common themes related to polymicrobial infections. This is a new conference that was approved via a competitive application process by the ASM Conference Committee. The main objectives of the conference are to: 1) promote information exchange regarding recent research concerning different types of polymicrobial infections, 2) foster interaction and collaboration between academic and private sector scientists within the disciplines of medical, dental and veterinary pathogenesis, 3) provide a forum for investigators from diverse research backgrounds and career stages to explore common themes in their research. The basic tenets of pathogenesis research were elucidated in Koch's postulates over 150 years ago, and reiterated in the so-called "molecular Koch's postulates" 25 years ago, and involve study of microbes in pure culture to minimize independent variables. However, with the growing availability and application of more sensitive and sophisticated methodology for tracking the epidemiology of infections, there is now a growing appreciation that the majority of infections involve interactions of multiple pathogens within the same host. In many cases, the interaction between the different microbes can profoundly influence the course, severity and treatability of an infection. Recognizing the potential impact o polymicrobial infections, the NIH has released several different solicitations for projects addressing these topics and there has been an explosion in researchers and work in this area. Nevertheless, with the exception of a number of symposia nested within the ASM General Meeting, and several small NIH sponsored workshops, there have not been meetings devoted to this topic. Therefore, this meeting bridging multiple disciplines and fields of study provides a important and unmet opportunity for exchange and development of ideas.