Cell Biologic approaches to Diabetes Research

糖尿病研究的细胞生物学方法

• 批准号: 8704288
• 负责人: MARCO COLONNA
• 金额: $ 17.12万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8704288
• 关键词: Cells; Diabetes Mellitus; Research

DESCRIPTION (provided by applicant): This renewal application for years 31-35 of a structured, basic research-oriented Diabetes Training Program consists of 14 faculty members to train Ph.D. scientists & physicians to investigate problems of Types 1 & 2 diabetes. Faculty number & composition has been trimmed to enhance research directly related to diabetes including: 1) insulin secretion & (-cell proliferation, 2) development of endodermal lineages including (-cells, 3) processing & presentation of antigens by histocompatibility molecules in Type 1 diabetes, 4) immune tolerance & autoimmunity in Type 1 diabetes, 5) KATP channels & neonatal diabetes, 6) Ca¿+-independent phospholipase A2 & (-cells 7) insulin resistance/diabetes in adult HIV disease, 8) diabetic neuropathy, 9) glucose transporters & Type 2 diabetes , 10) lipid synthesis, metabolism & vascular diseases in diabetes, 11) obesity, diabetes & nutrition, 12) diabetes-induced pregnancy loss & malformations. The mainstay of training is an independent research project in a mentor's laboratory & opportunities to collaborate with other mentors & basic scientists. The trainees & faculty actively participate by presenting their ongoing work at biweekly (-cell biology meetings. To broaden & strengthen their independent research projects, trainees also participate in weekly seminars on both basic & clinical issues in diabetes, endocrinology, metabolism and immunology. Trainees will present their research at national meetings, & career development will be enhanced by structured workshops in grant & manuscript writing and reviewing. All trainees will participate in "The Program for the Ethical and Responsible Conduct of Science & Scholarship". Trainees are generally recent graduates with PhD and/or MD degrees in areas of molecular biology & basic sciences & a commitment to research careers in diabetes and metabolic diseases. The duration of training is 3 years. Support is requested for 4 postdoctoral trainees. Our basic research-oriented postdoctoral training program complements & interacts with the Diabetes Research and Training Center, & a parallel clinically-oriented diabetes training program in the Department of Medicine. Washington University School of Medicine is an institution known for its excellence in basic & clinical diabetes research. Goals of this program are to provide postdoctoral trainees with research experience & skills necessary to gain extramural funding & career opportunities to develop into independent investigators with a career commitment to research & teaching in diabetes.

描述（由申请人提供）：本申请为31-35年的结构化，基础研究型糖尿病培训计划的续签申请，该计划由14名教师组成，旨在培养博士科学家和医生来研究1型和2型糖尿病的问题。为了加强与糖尿病直接相关的研究，已经削减了教师人数和组成，包括：1)胰岛素分泌和-细胞增殖，2)内胚层谱系包括-细胞的发育，3)1型糖尿病组织相容性分子对抗原的加工和递呈，4)1型糖尿病的免疫耐受和自身免疫，5)KATP通道和新生儿糖尿病，6)Ca独立磷脂酶A2和-细胞，7)成人HIV疾病中的胰岛素抵抗/糖尿病，8)糖尿病神经病变，9)葡萄糖转运蛋白和2型糖尿病，10)脂质合成，糖尿病的代谢和血管疾病，11)肥胖，糖尿病与营养，12)糖尿病导致的流产和畸形。培训的主要内容是在导师的实验室进行一个独立的研究项目，并有机会与其他导师和基础科学家合作。学员和教师积极参与，在两周一次的细胞生物学会议上展示他们正在进行的工作。为了扩大和加强他们的独立研究项目，学员还参加了关于糖尿病、内分泌学、代谢学和免疫学的基础和临床问题的每周研讨会。受训者将在全国会议上展示他们的研究成果，并且将通过在拨款、手稿写作和审查方面的结构化研讨会来促进职业发展。所有学员都将参加“科学与学术道德与负责任行为计划”。