Asymmetric Chemical Synthesis Methods via Cooperative Catalysis

协同催化的不对称化学合成方法

• 批准号: 9355214
• 负责人: Thomas Neil Snaddon
• 金额: $ 29.72万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355214
• 关键词: Address; Adopted; Ammonium; Architecture; Area; Biological; Carbon; Catalysis; Chemicals; Chemistry; Clinical; Communities; Complex; Data; Development; Disease; Esters; Event; Generic Drugs; Goals; Health; Human; Indole Alkaloids; Laboratories; Medicine; Methods; Molecular; Nature; Palladium; Preparation; Protocols documentation; Reaction; Research; Therapeutic Agents; Transition Elements; Work; base; chemical bond; chemical reaction; chemical synthesis; design; driving force; enolate; enzyme activity; flexibility; infancy; metal complex; molecular assembly/self assembly; next generation; novel therapeutics; programs; scaffold; synergism; tertiary amine; therapeutic development

Abstract The straightforward laboratory preparation of structural motifs commonly found in therapeutic agents is a major driving force in catalysis-based reaction design. In our laboratory we have adopted cooperative catalysis, an approach that emulates mechanisms encountered in enzymatic activity. In such a regime, merges of two (or more) simultaneous and complementary catalysis events are merged to forge a single chemical bond, via hitherto inaccessible chemical reactivity. Despite the infancy of this area, it promises much for the design of new, efficient and operationally trivial catalytic asymmetric reactions, and expedite the design, development and manufacture of medicines to manage and treat diseases. Based on exciting preliminary data we have obtained in the arena of cooperative catalysis, the program detailed in this proposal will provide the scientific community with straightforward, reliable and flexible methods for chemical synthesis This work will significantly impact human health and medicine by establishing routine synthetic protocols for the preparation of valuable molecular scaffolds, which will contribute to the design and development of new clinical agents.

摘要 治疗药物中常见的结构基元的直接实验室制备是主要的 基于催化的反应设计中的驱动力。在我们的实验室，我们采用了合作催化，一种 模拟酶活性中遇到的机理的方法。在这样的制度下，两个(或 更多)同时的和互补的催化事件被合并以形成单一的化学键，通过 迄今为止难以理解的化学反应。尽管这一领域还处于起步阶段，但它对设计 新的、高效的和操作琐碎的催化不对称反应，并加快设计、开发 以及制造管理和治疗疾病的药物。 基于我们在合作催化领域获得的令人兴奋的初步数据，该程序 本提案中的详细说明将为科学界提供直接、可靠和灵活的方法 对于化学合成，这项工作将通过建立常规程序对人类健康和医学产生重大影响 用于制备有价值的分子支架的合成方案，这将有助于设计和 开发新的临床药物。