Asymmetric Chemical Synthesis Methods via Cooperative Catalysis

协同催化的不对称化学合成方法

• 批准号: 9355214
• 负责人: Thomas Neil Snaddon
• 金额: $ 29.72万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-20 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9355214
• 关键词: Address; Adopted; Ammonium; Architecture; Area; Biological; Carbon; Catalysis; Chemicals; Chemistry; Clinical; Communities; Complex; Data; Development; Disease; Esters; Event; Generic Drugs; Goals; Health; Human; Indole Alkaloids; Laboratories; Medicine; Methods; Molecular; Nature; Palladium; Preparation; Protocols documentation; Reaction; Research; Therapeutic Agents; Transition Elements; Work; base; chemical bond; chemical reaction; chemical synthesis; design; driving force; enolate; enzyme activity; flexibility; infancy; metal complex; molecular assembly/self assembly; next generation; novel therapeutics; programs; scaffold; synergism; tertiary amine; therapeutic development

Abstract The straightforward laboratory preparation of structural motifs commonly found in therapeutic agents is a major driving force in catalysis-based reaction design. In our laboratory we have adopted cooperative catalysis, an approach that emulates mechanisms encountered in enzymatic activity. In such a regime, merges of two (or more) simultaneous and complementary catalysis events are merged to forge a single chemical bond, via hitherto inaccessible chemical reactivity. Despite the infancy of this area, it promises much for the design of new, efficient and operationally trivial catalytic asymmetric reactions, and expedite the design, development and manufacture of medicines to manage and treat diseases. Based on exciting preliminary data we have obtained in the arena of cooperative catalysis, the program detailed in this proposal will provide the scientific community with straightforward, reliable and flexible methods for chemical synthesis This work will significantly impact human health and medicine by establishing routine synthetic protocols for the preparation of valuable molecular scaffolds, which will contribute to the design and development of new clinical agents.

抽象的 在治疗剂中常见的结构基序的直接实验室制备是主要的 基于催化的反应设计中的驱动力。在我们的实验室中，我们采用了合作催化 模拟酶活性中遇到的机制的方法。在这样的制度中，合并了两个（或 更多）合并的同时和互补催化事件通过 迄今无法访问的化学反应性。尽管该领域还尚未 新的，有效的和操作的琐碎催化不对称反应，并加快设计，发展 并制造用于管理和治疗疾病的药物。 根据我们在合作催化的领域获得的令人兴奋的初步数据，该计划 该提案中的详细信息将为科学界提供直接，可靠和灵活的方法 对于化学综合，这项工作将通过建立常规来对人类健康和医学产生重大影响 制备有价值的分子支架的合成方案，这将有助于设计和 开发新的临床代理。