Dallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in Cognition
Dallas Lifespan Brain Study-Wave 3: Neurodegeneration & Resilience in Cognition
批准号:
9629886
负责人:
DENISE CORTIS PARK
金额:
$83.67万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-04-01 至 2022-08-31
关键词:
AddressAdultAffectAgeAlzheimer&aposs DiseaseAmericanAmyloidAmyloid beta-ProteinAutopsyAwardBlood VesselsBrainBrain DiseasesBrain scanCardiovascular systemCerebrovascular CirculationCerebrumCognitionCognitiveCognitive agingCoinCross-Sectional StudiesDataDepositionDiagnosisDiagnosticEducationEducational BackgroundElderlyEnsureFinancial compensationFunctional Magnetic Resonance ImagingFundingFutureGoalsHealthHippocampus (Brain)HypercapniaImageImpaired cognitionIndividualLeadLife ExperienceLongevityLongitudinal StudiesMaintenanceMeasurableMeasurementMeasuresMemoryModalityModelingNerve DegenerationNeurofibrillary TanglesOrganizational ChangeParticipantPathologicPathologyPatternPersonsPhasePositron-Emission TomographyPredictive ValueProceduresRadiopharmaceuticalsResearchRestRoleSamplingScanningScientistSideSignal TransductionStructureTauopathiesTestingThickTimeabeta accumulationabeta depositionage groupagedamyloid imagingbasebrain healthcerebrovascularcerebrovascular healthcognitive changecognitive functioncontextual factorsdesignexperiencefrailtyimaging modalityindexinglow socioeconomic statusmetabolic ratemiddle agemild cognitive impairmentnervous system disorderneuroimagingpre-clinicalpsychosocialrelating to nervous systemresiliencetau Proteinstau aggregationtool
中文摘要
达拉斯寿命脑研究(DLBS)提供了发生的变化的最完整的图片之一
英文摘要
The Dallas Lifespan Brain Study (DLBS) provides one of the most complete pictures of the changes that occur
in brain structure and brain function, as well as their consequences for cognition, over the lifespan. The
understanding of how healthy brains either maintain cognitive vitality or transition to pathology is the
bedrock upon which future cures for neurological diseases will be built. We must study the entire adult
lifespan to understand how early changes in brain structure and function signal future cognitive frailty. There
are contrasting models of how brain function changes with age to maintain cognition (maintenance model vs.
compensation model). We hypothesize that the model that best characterizes an individual is related to age
and life experiences. For example, we predict that brain maintenance underlies effective cognitive function in
middle-aged adults, whereas maintenance of cognitive function in old age more likely relies on a shift to
compensatory brain activity. The DLBS was initially funded in 2006 by a MERIT award to Denise Park, and
we have completed two waves of testing spaced four years apart. We now seek funding for Wave 3, which will
occur eight years after Wave 1. This third wave is perhaps the most exciting scientifically, as the eight-year
measurement period will allow us to isolate both those who are experiencing precipitous cognitive decline as
well as older adults who have largely maintained cognitive vitality over eight years. The study employs a
variety of neuroimaging tools that provide considerable breadth in the characterization of the brain, including
structural, functional, and vascular imaging as well as a detailed cognitive and psychosocial characterization of
participants. In addition, the DLBS also incorporates PET scans that measure deposits of beta amyloid and
levels of tau in the brain, identifying subjects who may be in a state of preclinical AD. High levels of amyloid
and tau neuropathologies are the primary diagnostic criteria for AD at autopsy, but are also commonly found
in healthy, cognitively asymptomatic adults, and the DLBS seeks to disentangle this puzzle. The DLBS focuses
on five important issues: (a) what neural footprint (maintenance model or compensation model) is associated
with 8-year trajectories of cognitive vitality versus cognitive decline; (b) whether high amyloid accumulation
in Wave 1 predicts progression at Wave 3, eight years later, to Mild Cognitive Impairment or Alzheimer's
Disease; (c) how life experiences and health factors, conceptualized as neural enrichment and neural depletion
factors, impact changes in brain function and cognition; (d) whether change in organization of brain networks
at different ages predicts cognitive vitality or decline; and (e) whether changes in cerebrovascular health
predicts cognitive trajectories. We can use these data to begin to understand the role of neural and contextual
factors in explaining, not only who progresses to a pathological brain disorder like AD, but also identify brain
patterns that characterize individuals who maintain cognitive function and brain health.
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Active Interventions for the Aging Mind
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批准号:7901196
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项目类别:
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资助金额:$29.07万
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财政年份:2009
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负责人:DENISE CORTIS PARK
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依托单位:
Impact of Exercise and Engagement on Cognition in Older Adults
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批准号:7938876
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项目类别:
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资助金额:$38.12万
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财政年份:2009
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负责人:DENISE CORTIS PARK
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依托单位:
Impact of Exercise and Engagement on Cognition in Older Adults
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批准号:7825072
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项目类别:
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资助金额:$39.21万
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财政年份:2009
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负责人:DENISE CORTIS PARK
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依托单位:
Neuroimaging of Dedifferentiation and Memory Across the Lifespan
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批准号:7817252
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项目类别:
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资助金额:$89.42万
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财政年份:2009
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:7917232
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项目类别:
-
资助金额:$43.5万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:8131777
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项目类别:
-
资助金额:$42.81万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:7212673
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项目类别:
-
资助金额:$41.83万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:7671228
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项目类别:
-
资助金额:$42.93万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:8286840
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项目类别:
-
资助金额:$9.0万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Active Interventions for the Aging Mind
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批准号:7500065
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项目类别:
-
资助金额:$41.95万
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财政年份:2007
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:6805127
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项目类别:
-
资助金额:$35.52万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:6936470
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项目类别:
-
资助金额:$36.12万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:6699596
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项目类别:
-
资助金额:$34.94万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:7684911
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项目类别:
-
资助金额:$24.8万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:7678114
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项目类别:
-
资助金额:$6.0万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
Center for Healthy Minds
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批准号:7272758
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项目类别:
-
资助金额:$30.29万
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财政年份:2003
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负责人:DENISE CORTIS PARK
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依托单位:
COGNITIVE AND NEUROCHEMICAL FUNCTION IN FIBROMYALGIA
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批准号:6416836
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项目类别:
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资助金额:$11.52万
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财政年份:2001
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负责人:DENISE CORTIS PARK
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依托单位:
MEDICAL ENVIRONMENT INFORMATION PROCESSED IN ELDERLY--HEALTH BEHAVIOR
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批准号:6323252
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项目类别:
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资助金额:$10.69万
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财政年份:2000
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负责人:DENISE CORTIS PARK
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依托单位:
CORE--INFORMATION DISSEMINATION
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批准号:6323255
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项目类别:
-
资助金额:$10.69万
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财政年份:2000
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负责人:DENISE CORTIS PARK
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依托单位:
COGNITIVE AND NEUROCHEMICAL FUNCTION IN FIBROMYALGIA
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批准号:6299780
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项目类别:
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资助金额:$11.52万
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财政年份:2000
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负责人:DENISE CORTIS PARK
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依托单位:
海外基金