African Ancestry Genomic Psychiatry Cohort

非洲血统基因组精神病学队列

• 批准号: 9442831
• 负责人: MICHELE T PATO
• 金额: $ 176.85万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-18 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9442831
• 关键词: Affect; African; African American; Area; Bipolar Disorder; Clinical; Collaborations; Collection; Communities; Complement; Consent; Copy Number Polymorphism; Custom; DSM-IV; Data; Databases; Enrollment; Europe; European; Family; Family history of; Family member; Follow-Up Studies; Gene Frequency; Genetic; Genetic Polymorphism; Genetic Variation; Genome; Genomic DNA; Genomics; Goals; Haplotypes; Individual; Institutes; Investments; Medical; Medical Records; Molecular Analysis; National Institute of Mental Health; Participant; Patients; Phenotype; Philanthropic Fund; Population; Proteins; Psychiatry; Recording of previous events; Research; Resources; Risk; SNP array; SNP genotyping; Sample Size; Sampling; Schizophrenia; Scientist; Standardization; Variant; case control; cohort; database of Genotypes and Phenotypes; density; exome sequencing; follow-up; genetic analysis; genome sequencing; genome-wide; insight; next generation; prospective; psychogenetics; public health relevance; whole genome

 DESCRIPTION (provided by applicant): The African Ancestry-Genomic Psychiatry Cohort (AA-GPC), will support a large expansion of the Genomic Psychiatry Cohort (GPC) (current n=33,000) that expands the collection and genomic analysis of patients suffering with schizophrenia and controls with African ancestry (AA). The GPC is a large clinical cohort of patients with schizophrenia (n=10,000), patients with bipolar disorder (n=5,000), family members (n=3,000), and control participants with no history or family history of schizophrenia or bipolar disorder (n=15,000) (Pato, 2013). The GPC's successful enrollment of nearly 6,000 AA research participants (3,000 suffering from schizophrenia and 3,000 controls) supports the enrollment capacity of the GPC network in African American communities. Our objective through this project is to increase AA schizophrenia cohorts to 22,000 research participants (11,000 AA patients suffering from schizophrenia and 11,000 AA controls), and to draw upon the genomes of these individuals to increase our understanding of genetic influences on schizophrenia. More specifically: 1) We will create an overall GPC cohort for the field of 18,525 AA participants - 8,817 suffering from schizophrenia and 9,708 controls - by enrolling an additional 5,817 patients and 6,708 control participants. Existing NIMH AA samples (2,183 cases and 1,292 controls) will be added to the extent allowed under existing consents and availability of bio-samples. In total, the maximum number of AA samples to be genomically characterized is 22,000. 2) We will study genome variation in this large African-ancestry schizophrenia cohort - using a strategic combination of exome sequencing, custom array analysis, and whole genome sequencing - to both broaden and deepen our understanding of genetic variation that influences risk of schizophrenia. As with our current efforts in this area, NIMH investment will be amplified by a contribution of philanthropic funds from the Broad Institute's Stanley Center for Psychiatric Research.

 描述（由申请人提供）：非洲精神病学-基因组精神病学队列（AA-GPC）将支持基因组精神病学队列（GPC）（目前n= 33，000）的大规模扩展，该队列扩大了精神分裂症患者和非洲血统（AA）对照组的收集和基因组分析。GPC是一个大型临床队列，包括精神分裂症患者（n= 10，000）、双相情感障碍患者（n= 5，000）、家庭成员（n= 3，000）和无精神分裂症或双相情感障碍病史或家族史的对照受试者（n= 15，000）（Pato，2013）。GPC成功招募了近6，000名AA研究参与者（3，000名精神分裂症患者和3，000名对照组），支持了GPC网络在非裔美国人社区的招募能力。我们通过这个项目的目标是将AA精神分裂症队列增加到22，000名研究参与者（11，000名患有精神分裂症的AA患者和11，000名AA对照），并利用这些个体的基因组来增加我们对精神分裂症遗传影响的理解。更具体地说：1）我们将为18，525名AA参与者（8，817名精神分裂症患者和9，708名对照者）创建一个整体GPC队列，额外招募5，817名患者和6，708名对照参与者。将在现有同意书和生物样本可用性允许的范围内增加现有NIMH AA样本（2，183例病例和1，292例对照）。总的来说，待进行基因组表征的AA样品的最大数量为22，000。2)我们将研究这个大型非洲血统精神分裂症队列的基因组变异-使用外显子组测序，自定义阵列分析和全基因组测序的战略组合-以拓宽和加深我们对影响精神分裂症风险的遗传变异的理解。与我们目前在这一领域的努力一样，NIMH的投资将通过布罗德研究所斯坦利精神病学研究中心的慈善基金的捐款来扩大。