Genomic Psychiatry Cohort

基因组精神病学队列

• 批准号: 8492939
• 负责人: MICHELE T PATO
• 金额: $ 57.37万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8492939
• 关键词: Academic Medical Centers; Bioinformatics; Biological; Biological Markers; Bipolar Disorder; Blood; California; Candidate Disease Gene; Caucasians; Caucasoid Race; Characteristics; Clinical; Clinical Data; Collaborations; Collection; Consent; DNA; Data; Deposition; Diagnosis; Diagnostic; Diagnostic and Statistical Manual; Disease; Endowment; Environmental Risk Factor; Epigenetic Process; Equilibrium; Etiology; Family history of; Financial Support; Foundations; Funding; Future; General Hospitals; Genetic; Genetic Heterogeneity; Genetic Risk; Genome; Genomics; Genotype; Geographic Locations; Goals; Grant; Health system; Human Genetics; Image; Indium; Institutes; International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10); Interview; Investigation; Island; Latino; Massachusetts; Measurement; Mental disorders; Molecular; Mutation; National Institute of Mental Health; Nested Case-Control Study; Patients; Phenotype; Population; Population Study; Predisposition; Prevention; Psychiatry; Psychotic Disorders; Recruitment Activity; Research; Research Design; Research Infrastructure; Research Personnel; Resource Sharing; Resources; Rest; Risk; Sampling; Schizophrenia; Single Nucleotide Polymorphism; Site; Specificity; Specimen; Stratification; Structure; Study Subject; Symptoms; Time; Universities; Variant; Work; base; clinical phenotype; cohort; cost effective; design; experience; follow-up; functional genomics; genetic analysis; genetic resource; genome wide association study; genome-wide; innovation; instrument; member; patient population; phenomics; prospective; repository; research clinical testing; response; tool; trait; treatment response

DESCRIPTION (provided by applicant): Genomic Parsing of Bipolar Disorder and Schizophrenia: Studies of Large Cohorts in the U.S. and Across the Globe". The University of Southern California (USC Center for Genomic Psychiatry), the Massachusetts General Hospital (MGH)-Broad Institute (Stanley Center) and a nation-wide network of academic medical centers have created the Genomic Psychiatry Cohort (GPC). This application seeks to expand the resources currently available to the field, through the NIMH Repository, with an additional sample of 10,000 well-characterized patients with schizophrenia and 10,000 controls from the same geographic regions. Further, a genome-wide association study of 5,000 patients and 5,000 controls will be performed to identify genetic risks for schizophrenia. The blood/DNA from the 20,000 subjects will be deposited in the NIMH repository, along with clinical and phenotypic data, and genome wide SNP data from the GWA study. In addition, we plan to genotype the second 10,000 subjects for ancestry informative markers and replication of candidate genes. Our intent is to ascertain and recruit a large clinical cohort of patients with schizophrenia that will be prospectively followed in order to allow ongoing careful assessment of phenotype and the possibility of future nested case-control studies. We will also provide the bioinformatics and molecular infrastructure for rapid replication of specific genetic results and future potential large-scale high-throughput genomic investigations. The University of Southern California (USC) and its partners have created the Genomic Psychiatry Cohort to study very large groups of patients suffering with schizophrenia treated in their health systems. Members of the cohort are long-term patients that have agreed to participate in studies related to understanding the genetic and environmental risks for these disorders. This type of population study is critical to understanding risk, helping develop treatments, and understanding prevention of this major illness.

描述（由申请人提供）：双相情感障碍和精神分裂症的基因组解析：美国和全球大型队列的研究”。南加州大学（南加州大学基因组精神病学中心）、马萨诸塞州总医院 (MGH)-布罗德研究所（斯坦利中心）和全国学术医疗中心网络创建了基因组精神病学队列 (GPC)。本申请寻求到 通过 NIMH 存储库，扩大该领域目前可用的资源，增加来自同一地理区域的 10,000 名特征明确的精神分裂症患者和 10,000 名对照样本。此外，还将对 5,000 名患者和 5,000 名对照者进行全基因组关联研究，以确定精神分裂症的遗传风险。 20,000 名受试者的血液/DNA 将与临床和表型一起存放在 NIMH 存储库中 数据，以及来自 GWA 研究的全基因组 SNP 数据。此外，我们计划对第二个 10,000 名受试者进行基因分型，以获取祖先信息标记和候选基因的复制。我们的目的是确定并招募大量精神分裂症患者的临床队列，对这些患者进行前瞻性随访，以便对表型进行持续仔细的评估，并为未来进行巢式病例对照研究提供可能性。我们还将提供 用于快速复制特定遗传结果和未来潜在的大规模高通量基因组研究的生物信息学和分子基础设施。南加州大学 (USC) 及其合作伙伴创建了基因组精神病学队列，以研究在其卫生系统中接受治疗的大量精神分裂症患者。该队列的成员是长期患者，他们同意参加与了解遗传和环境相关的研究。 这些疾病的风险。此类人群研究对于了解风险、帮助开发治疗方法以及了解这种重大疾病的预防至关重要。

项目成果

Whole genome sequencing in psychiatric disorders: the WGSPD consortium.

• DOI: 10.1038/s41593-017-0017-9
• 发表时间: 2017-12
• 期刊: Nature neuroscience
• 影响因子: 25
• 作者: Sanders SJ;Neale BM;Huang H;Werling DM;An JY;Dong S;Whole Genome Sequencing for Psychiatric Disorders (WGSPD);Abecasis G;Arguello PA;Blangero J;Boehnke M;Daly MJ;Eggan K;Geschwind DH;Glahn DC;Goldstein DB;Gur RE;Handsaker RE;McCarroll SA;Ophoff RA;Palotie A;Pato CN;Sabatti C;State MW;Willsey AJ;Hyman SE;Addington AM;Lehner T;Freimer NB
• 通讯作者: Freimer NB

Traumatic brain injury and bipolar psychosis in the Genomic Psychiatry Cohort.

基因组精神病学队列中的创伤性脑损伤和双相精神病。

• DOI: 10.1002/ajmg.b.32350
• 发表时间: 2016
• 期刊: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
• 作者: Cieslak,Kristina;Pato,Michelle;Buckley,Peter;Pato,Carlos;Sobell,JanetL;Medeiros,Helena;Zhao,Yuan;Ahn,Hongshik;GenomicPsychiatryCohortConsortium;Malaspina,Dolores
• 通讯作者: Malaspina,Dolores

Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder.

精神分裂症或分裂情感障碍患者的药物使用与睡眠时间短有关。

• DOI: 10.1002/ajmg.b.32374
• 发表时间: 2016
• 期刊: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
• 作者: Tang,VivianK;Pato,MicheleT;Sobell,JanetL;Hammond,TereseC;Valdez,MarkM;Lane,ChristianneJ;GenomicPsychiatryCohortConsortium;Pato,CarlosN
• 通讯作者: Pato,CarlosN

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

• DOI: 10.1038/s41380-019-0558-2
• 发表时间: 2021-04
• 期刊: Molecular psychiatry
• 影响因子: 11
• 作者: Andlauer TFM;Guzman-Parra J;Streit F;Strohmaier J;González MJ;Gil Flores S;Cabaleiro Fabeiro FJ;Del Río Noriega F;Perez FP;Haro González J;Orozco Diaz G;de Diego-Otero Y;Moreno-Küstner B;Auburger G;Degenhardt F;Heilmann-Heimbach S;Herms S;Hoffmann P;Frank J;Foo JC;Treutlein J;Witt SH;Cichon S;Kogevinas M;Bipolar Disorder Working Group of the Psychiatric Genomics Consortium;Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium;Rivas F;Mayoral F;Müller-Myhsok B;Forstner AJ;Nöthen MM;Rietschel M
• 通讯作者: Rietschel M

Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis.

父亲年龄效应：精神分裂症的复制，伴有和不伴有精神病的双相情感障碍之间有趣的分离。

• DOI: 10.1002/ajmg.b.32334
• 发表时间: 2016
• 期刊: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
• 作者: Lehrer,DouglasS;Pato,MicheleT;Nahhas,RamziW;Miller,BrianR;Malaspina,Dolores;Buckley,PeterF;Sobell,JanetL;Walsh-Messinger,Julie;GenomicPsychiatryCohortConsortium;Pato,CarlosN
• 通讯作者: Pato,CarlosN