Noninvasive Stimulation to Improve Hippocampal-Dependent Memory in Older Adults

无创刺激可改善老年人海马依赖性记忆

• 批准号: 9413288
• 负责人: JOEL L VOSS
• 金额: $ 46.88万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9413288
• 关键词: Activities of Daily Living; Adult; Aftercare; Age-Related Memory Disorders; Aging; Alzheimer' s Disease; Behavioral; Brain; Brain imaging; Brain region; Cognitive; Collection; Data; Diagnosis; Double-Blind Method; Elderly; Ensure; Family health status; Fostering; Frequencies; Functional Magnetic Resonance Imaging; Goals; Healthcare Systems; Hippocampus (Brain); Human; Individual; Intervention; Knowledge; Laboratories; Location; Magnetic Resonance Imaging; Measurement; Measures; Memory; Memory Disorders; Memory Loss; Memory impairment; Methods; Nerve Degeneration; Neurophysiology - biologic function; Neuropsychology; Patients; Performance; Procedures; Quality of life; Research; Rest; Sampling; Shapes; Societies; Structure; Symptoms; Techniques; Testing; Translating; age related; age related neurodegeneration; base; behavior test; cognitive testing; combat; design; efficacy testing; experimental study; high dimensionality; improved; insight; instrument; long term memory; mild cognitive impairment; neuroimaging; public health relevance; relating to nervous system; satisfaction; simulation; treatment effect; young adult

DESCRIPTION (provided by applicant): Memory impairment is a major challenge for healthy older adults as well as those with age-related neurodegenerative diseases such as Alzheimer's disease and Mild Cognitive Impairment (MCI). Unfortunately there are no current treatments that reliably and robustly improve memory abilities for older adults. The goal of this project is to better understand and to improve a new potential treatment for memory impairment developed by the investigative team. This procedure involves noninvasive stimulation of the hippocampal brain network necessary for memory, and is called "Hipp-Stim." We have previously shown that Hipp-Stim can produce robust and lasting enhancement of the hippocampal network and associative (hippocampal-dependent) memory in young healthy individuals. The current proposal is to test efficacy and mechanisms of action in healthy elderly adults and in MCI patients. The effects of stimulation will be observed on tests of hippocampal- dependent memory and on brain imaging measures of hippocampal network function obtained in relation to memory capabilities. Sham-controlled, double-blind experiment designs will be used to ensure that treatment effects are specific to stimulation. Furthermore, comprehensive cognitive assessments will test selectivity of stimulation effects to memory, and neuroimaging analyses will test selectivity of stimulation effects to hippocampal brain networks. Improvements in memory performance will be assessed in relation to changes in individual's ability to perform and satisfaction with activities of daily living, in order to identify ramifications of improved memory for life quality. By performing Hipp-Stim experiments using a variety of hypothesis-driven stimulation intensities, frequencies, and delivery locations, we will determine optimal parameters for producing the greatest positive effects on memory ability, hippocampal network function, and life quality. A group of individuals with MCI will receive treatment using the optima stimulation parameters in order to determine if Hipp-Stim is effective for this condition. All experiments involve sophisticated assessments of hippocampal- dependent memory performance and hippocampal brain network function. The findings will thus deeply inform knowledge of stimulation effects and therefore foster better understanding of relevant mechanisms of action on memory-related brain regions in older adults. Insights from this research could propel understanding of age- related memory impairment and its treatment by noninvasive stimulation, while also producing new methods to combat age-related and neurodegenerative loss of memory abilities.

描述（由申请人提供）：记忆障碍对于健康的老年人以及患有与年龄相关的神经退行性疾病（例如阿尔茨海默病和轻度认知障碍（MCI））的人来说是一个主要挑战。不幸的是，目前尚无可靠且有力地提高老年人记忆能力的治疗方法。该项目的目标是更好地理解和改进研究团队开发的一种新的潜在治疗记忆障碍的方法。该过程涉及对记忆所需的海马脑网络进行无创刺激，称为“Hipp-Stim”。我们之前已经证明，Hipp-Stim 可以对年轻健康个体的海马网络和联想（海马依赖性）记忆产生强大而持久的增强。目前的提议是测试健康老年人和 MCI 患者的疗效和作用机制。将通过海马依赖性记忆测试和与记忆能力相关的海马网络功能的脑成像测量来观察刺激的效果。将使用假对照、双盲实验设计来确保治疗效果针对刺激。此外，综合认知评估将测试刺激效应对记忆的选择性，神经影像分析将测试刺激效应对海马脑网络的选择性。将根据个人执行能力的变化和对日常生活活动的满意度来评估记忆表现的改善，以确定记忆改善对生活质量的影响。通过使用各种假设驱动的刺激强度、频率和传递位置进行 Hipp-Stim 实验，我们将确定对记忆能力、海马网络功能和生活质量产生最大积极影响的最佳参数。一组患有 MCI 的个体将接受使用最佳刺激参数的治疗，以确定 Hipp-Stim 是否对这种情况有效。所有实验都涉及对海马依赖性记忆表现和海马大脑网络功能的复杂评估。因此，这些发现将深入了解刺激效应，从而促进更好地理解老年人记忆相关大脑区域的相关作用机制。这项研究的见解可以促进对与年龄相关的记忆障碍及其通过无创刺激进行治疗的理解，同时还可以产生新的方法来对抗与年龄相关的记忆能力和神经退行性丧失。