Physical Activity and neuropsychological outcomes in a cancer population

癌症人群的体力活动和神经心理学结果

• 批准号: 9515907
• 负责人: Sheri J Hartman
• 金额: $ 17.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-08 至 2019-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9515907
• 关键词: Accelerometer; Address; Adult; Anxiety; Area; Attention; Attention Concentration; Award; Behavior Therapy; Behavioral Medicine; Behavioral Research; Biological; Biometry; Blood; Body Weight decreased; Brain; Breast Cancer survivor; C-reactive protein; Cancer Center; Cancer Control; Cancer Patient; Cancer Survivor; Cognition; Cognitive; Complement; Computer software; Data; Diagnosis; Dietary Intervention; Doctor of Philosophy; Ensure; Fasting; Fatigue; Goals; Impaired cognition; Impairment; Inflammation; Inflammatory; Inflammatory Response; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Intervention; Intervention Studies; Knowledge; Language; Lead; Learning; Link; Malignant Neoplasms; Manuscripts; Measures; Mediating; Mediation; Mediator of activation protein; Medical Oncologist; Memory; Mental Depression; Mentors; Mentorship; Metabolism; Modeling; Neuropsychological Tests; Neuropsychology; Outcome; Participant; Patient Self-Report; Patients; Physical activity; Population; Preparation; Psyche structure; Quality of life; Randomized Controlled Trials; Reporting; Research; Research Activity; Research Personnel; Research Project Grants; Risk Factors; Schools; Techniques; Testing; Training; Training Activity; Training Programs; Woman; arm; cancer prevention; cancer therapy; career; career development; cognitive function; executive function; experience; improved; inflammatory marker; innovation; malignant breast neoplasm; member; neurotropic; post-doctoral training; prevent; programs; psychologic; public health relevance; recruit; sedentary; skills; treatment arm

DESCRIPTION (provided by applicant): This K07 proposal details a comprehensive program of training activities, mentorship, and research project that will provide the applicant (Sheri Hartman, PhD) with the support, knowledge, and skills to launch a career as an independent investigator. The training and research activities will focus on physical activity, neuropsychological outcomes, quality of life, and related biological mechanisms in cancer survivors. Dr. Hartman will conduct a 3-month randomized controlled trial of a physical activity intervention with women who were diagnosed with breast cancer to address the following aims: 1. To explore the effects of a physical activity intervention on changes in neuropsychological outcomes among breast cancer survivors 2.To explore the effects of a physical activity intervention on changes in cognitive complaints among breast cancer survivors 3. To examine biological mechanisms potentially linking physical activity with changes in neuropsychological testing and cognitive complaints. Eighty sedentary breast cancer survivors will be assessed at baseline and 3 months with accelerometer measured physical activity, neuropsychological testing, a measure of cognitive complaints, fasting blood draw, and psychological measures. To address the primary and secondary aims, Dr. Hartman will test whether, compared to control participants, women in the physical activity arm of the trial will experience statistically signifiant improvements in neuropsychological testing and decreases in a measure of cognitive complaints. To address the tertiary aim, Dr. Hartman will test whether changes in biological measures (BDNF, IGF-1, HOMA-IR, CRP) completely or partially explain the effect of the physical activity intervention on changes in neuropsychological tests and cognitive complaints. To successfully address the aims of the proposal, Dr. Hartman is building upon her previous training, has developed an extensive training plan, and has gathered an expert team of mentors. This proposal combines Dr. Hartman's graduate school training, focused on neuropsychological outcomes, cognitive complaints, and quality of life in cancer survivors, with her postdoctoral training in behavioral medicine, focused on physical activity interventions. While this proposal builds off of Dr. Hartman's strengths, it also will broaden her training and expertise in several key areas including understanding and incorporation of biological measures into behavioral research. The proposed plan has 5 training goals: Training goal #1: Gain experience and training in the incorporation of biological measures into behavioral intervention research. Training goal #2: Obtain training in metabolism and inflammation in order to understand how insulin action, inflammatory response, physical activity, and cognition are interrelated. Training goal #3: Further develop statistical training, by learning new software programs and new statistical analytic techniques, including modeling longitudinal data and mediation analysis techniques. Training goal #4: Acquire additional training on interpretation and understanding of neuropsychological testing and cognitive complaints. Training goal #5: Improve skills in manuscript preparation and grantsmanship, as well as career development. Dr. Hartman has gathered an expert team of mentors and consultants so that she may successfully achieve each of these goals. The primary mentor, Dr. Patterson, is the leader of the Cancer Prevention & Control Program at the Moores UCSD Cancer Center, and has considerable experience incorporating biological measures into weight loss and nutrition interventions. Other mentorship team members will ensure that Dr. Hartman achieves her training and research goals in the areas of metabolism and inflammation (Dr. Dorothy Sears), biostatistics (Dr. Loki Natarajan), and neuropsychological testing and cognitive complaints (Dr. Barton Palmer). In addition a medical oncologist consultant will provide guidance during the randomized controlled trial related to recruiting and conducting an intervention with breast cancer survivors (Dr. Barbara Parker). This knowledgeable and skilled team will enable Dr. Hartman to successfully accomplish the proposed K07 and use that experience to build an innovative research career focused on biological mechanisms of how physical activity influences neuropsychological outcomes and cognitive complaints in cancer survivors. The support provided by this K07 award, the proposed training activities, and research project described in this proposal complement Dr. Hartman's previous experience and provide an exceptional opportunity for her to broaden her research focus and transition to a career as an independent investigator.

描述(由申请者提供)：这份K07计划书详细介绍了培训活动、指导和研究项目的综合计划，该计划将为申请者(Sheri Hartman，博士)提供支持、知识和技能，以开始独立调查人员的职业生涯。培训和研究活动将侧重于癌症幸存者的体力活动、神经心理结果、生活质量和相关的生物机制。哈特曼博士将对确诊为乳腺癌的女性进行为期3个月的体力活动干预的随机对照试验，以达到以下目的：1.探索体力活动干预对乳腺癌幸存者神经心理结果变化的影响；2.探索体力活动干预对乳腺癌幸存者认知主诉变化的影响3.研究体力活动与神经心理测试和认知主诉变化之间的潜在联系的生物学机制。80名久坐不动的乳腺癌幸存者将在基线和3个月内接受加速计测量的体力活动、神经心理测试、认知主诉测量、空腹抽血和心理测量。为了解决主要目标和次要目标，哈特曼博士将测试，与对照组参与者相比，试验中体力活动组的女性在神经心理测试中是否会有统计上的显著改善，并在认知投诉的一项指标上有所减少。为了解决第三个目标，哈特曼博士将测试生物学指标(BDNF、IGF-1、HOMA-IR、CRP)的变化是否完全或部分解释了体力活动干预对神经心理测试和认知主诉的变化的影响。为了成功地实现该提案的目标，哈特曼博士正在她之前的培训基础上再接再厉，制定了广泛的培训计划，并组建了一支由导师组成的专家团队。这项建议结合了哈特曼博士研究生院的培训，重点是癌症幸存者的神经心理结果、认知抱怨和生活质量，以及她的博士后行为医学培训，重点是体力活动干预。虽然这项建议是基于哈特曼博士的优势，但它也将拓宽她在几个关键领域的培训和专业知识，包括理解生物测量并将其纳入行为研究。拟议的计划有5个培训目标：培训目标1：在将生物措施纳入行为干预研究方面获得经验和培训。培训目标2：接受新陈代谢和炎症方面的培训，以了解胰岛素的作用、炎症反应、体力活动和认知是如何相互关联的。培训目标3：通过学习新的软件程序和新的统计分析技术，包括建立纵向数据模型和中介分析技术，进一步开展统计培训。培训目标4：获得关于神经心理测试和认知投诉的解释和理解的额外培训。培训目标5：提高手稿准备和培训技能，以及职业发展。哈特曼博士召集了一个由导师和顾问组成的专家团队，这样她就可以成功地实现这些目标中的每一个。主要导师Patterson博士是摩尔斯加州大学圣迭戈分校癌症中心癌症预防和控制项目的负责人，他在将生物措施融入减肥和营养干预方面拥有丰富的经验。其他指导团队成员将确保Hartman博士在新陈代谢和炎症(Dorothy Sears博士)、生物统计学(Loki Natarajan博士)以及神经心理测试和认知疾病(Barton Palmer博士)领域实现她的培训和研究目标。此外，一名内科肿瘤学家顾问将在随机对照试验期间提供指导，涉及招募乳腺癌幸存者并对其进行干预(芭芭拉·帕克博士)。这个知识渊博、技术娴熟的团队将使哈特曼博士能够成功地完成拟议的K07，并利用这一经验建立一个创新的研究生涯，专注于身体活动如何影响癌症幸存者的神经心理结果和认知症状的生物机制。这项K07奖项提供的支持、建议的培训活动和本提案中描述的研究项目补充了Hartman博士以前的经验，并为她提供了一个扩大研究重点并过渡到独立调查员职业生涯的绝佳机会。

项目成果

Breast cancer survivors reduce accelerometer-measured sedentary time in an exercise intervention.

乳腺癌幸存者在运动干预中减少了加速计测量的静坐时间。

• DOI: 10.1007/s11764-019-00768-8
• 发表时间: 2019
• 期刊: Journal of cancer survivorship : research and practice
• 作者: Weiner,LaurenS;Takemoto,Michelle;Godbole,Suneeta;Nelson,SandahlH;Natarajan,Loki;Sears,DorothyD;Hartman,SheriJ
• 通讯作者: Hartman,SheriJ