Physical Activity and neuropsychological outcomes in a cancer population

描述（由申请人提供）：本 K07 提案详细介绍了培训活动、指导和研究项目的综合计划，该计划将为申请人（Sheri Hartman 博士）提供支持、知识和技能，以开启独立研究者的职业生涯。培训和研究活动将重点关注癌症幸存者的体力活动、神经心理学结果、生活质量和相关生物学机制。 Hartman 博士将对被诊断患有乳腺癌的女性进行为期 3 个月的体力活动干预随机对照试验，以实现以下目标： 1. 探讨体力活动干预对乳腺癌幸存者神经心理学结果变化的影响 2. 探讨体力活动干预对乳腺癌幸存者认知症状变化的影响 3. 研究将体力活动与神经心理测试和认知症状变化联系起来的潜在生物学机制。将在基线和 3 个月内对 80 名久坐的乳腺癌幸存者进行评估，包括加速计测量的体力活动、神经心理学测试、认知症状测量、空腹抽血和心理测量。为了解决主要和次要目标，哈特曼博士将测试与对照组参与者相比，试验中体育活动组的女性是否会在神经心理学测试方面经历统计学上的显着改善，并在一定程度上减少认知抱怨。为了实现第三个目标，Hartman 博士将测试生物指标（BDNF、IGF-1、HOMA-IR、CRP）的变化是否能够完全或部分解释体力活动干预对神经心理学测试和认知抱怨变化的影响。为了成功实现该提案的目标，哈特曼博士在她之前的培训基础上，制定了广泛的培训计划，并组建了一支专家导师团队。该提案结合了哈特曼博士的研究生院培训（重点关注癌症幸存者的神经心理学结果、认知症状和生活质量）和她在行为医学方面的博士后培训（重点关注身体活动干预）。虽然该提案建立在哈特曼博士的优势之上，但它也将扩大她在几个关键领域的培训和专业知识，包括理解生物学测量并将其纳入行为研究。拟议计划有 5 个培训目标： 培训目标#1：获得将生物测量纳入行为干预研究的经验和培训。培训目标#2：获得新陈代谢和炎症方面的培训，以了解胰岛素作用、炎症反应、体力活动和认知之间的相互关系。培训目标#3：通过学习新的软件程序和新的统计分析技术，包括纵向数据建模和中介分析技术，进一步发展统计培训。培训目标#4：获得关于神经心理学测试和认知投诉的解释和理解的额外培训。培训目标#5：提高稿件准备和资助以及职业发展的技能。哈特曼博士聚集了一支由导师和顾问组成的专家团队，以便她能够成功实现这些目标。主要导师 Patterson 博士是加州大学圣地亚哥分校摩尔斯癌症中心癌症预防与控制项目的负责人，在将生物措施纳入减肥和营养干预方面拥有丰富的经验。其他导师团队成员将确保 Hartman 博士实现她在新陈代谢和炎症（Dorothy Sears 博士）、生物统计学（Loki Natarajan 博士）以及神经心理学测试和认知投诉（Barton Palmer 博士）领域的培训和研究目标。此外，肿瘤内科医生顾问将在随机对照试验期间提供与乳腺癌幸存者招募和干预相关的指导（芭芭拉·帕克博士）。这个知识渊博、技术精湛的团队将使 Hartman 博士能够成功完成拟议的 K07，并利用这一经验建立创新的研究生涯，重点关注身体活动如何影响癌症幸存者的神经心理结果和认知抱怨的生物机制。 K07 奖项提供的支持、拟议的培训活动以及本提案中描述的研究项目补充了 Hartman 博士之前的经验，并为她提供了一个难得的机会，可以扩大她的研究重点并过渡到作为一名独立研究者的职业生涯。

DESCRIPTION (provided by applicant): This K07 proposal details a comprehensive program of training activities, mentorship, and research project that will provide the applicant (Sheri Hartman, PhD) with the support, knowledge, and skills to launch a career as an independent investigator. The training and research activities will focus on physical activity, neuropsychological outcomes, quality of life, and related biological mechanisms in cancer survivors. Dr. Hartman will conduct a 3-month randomized controlled trial of a physical activity intervention with women who were diagnosed with breast cancer to address the following aims: 1. To explore the effects of a physical activity intervention on changes in neuropsychological outcomes among breast cancer survivors 2.To explore the effects of a physical activity intervention on changes in cognitive complaints among breast cancer survivors 3. To examine biological mechanisms potentially linking physical activity with changes in neuropsychological testing and cognitive complaints. Eighty sedentary breast cancer survivors will be assessed at baseline and 3 months with accelerometer measured physical activity, neuropsychological testing, a measure of cognitive complaints, fasting blood draw, and psychological measures. To address the primary and secondary aims, Dr. Hartman will test whether, compared to control participants, women in the physical activity arm of the trial will experience statistically signifiant improvements in neuropsychological testing and decreases in a measure of cognitive complaints. To address the tertiary aim, Dr. Hartman will test whether changes in biological measures (BDNF, IGF-1, HOMA-IR, CRP) completely or partially explain the effect of the physical activity intervention on changes in neuropsychological tests and cognitive complaints. To successfully address the aims of the proposal, Dr. Hartman is building upon her previous training, has developed an extensive training plan, and has gathered an expert team of mentors. This proposal combines Dr. Hartman's graduate school training, focused on neuropsychological outcomes, cognitive complaints, and quality of life in cancer survivors, with her postdoctoral training in behavioral medicine, focused on physical activity interventions. While this proposal builds off of Dr. Hartman's strengths, it also will broaden her training and expertise in several key areas including understanding and incorporation of biological measures into behavioral research. The proposed plan has 5 training goals: Training goal #1: Gain experience and training in the incorporation of biological measures into behavioral intervention research. Training goal #2: Obtain training in metabolism and inflammation in order to understand how insulin action, inflammatory response, physical activity, and cognition are interrelated. Training goal #3: Further develop statistical training, by learning new software programs and new statistical analytic techniques, including modeling longitudinal data and mediation analysis techniques. Training goal #4: Acquire additional training on interpretation and understanding of neuropsychological testing and cognitive complaints. Training goal #5: Improve skills in manuscript preparation and grantsmanship, as well as career development. Dr. Hartman has gathered an expert team of mentors and consultants so that she may successfully achieve each of these goals. The primary mentor, Dr. Patterson, is the leader of the Cancer Prevention & Control Program at the Moores UCSD Cancer Center, and has considerable experience incorporating biological measures into weight loss and nutrition interventions. Other mentorship team members will ensure that Dr. Hartman achieves her training and research goals in the areas of metabolism and inflammation (Dr. Dorothy Sears), biostatistics (Dr. Loki Natarajan), and neuropsychological testing and cognitive complaints (Dr. Barton Palmer). In addition a medical oncologist consultant will provide guidance during the randomized controlled trial related to recruiting and conducting an intervention with breast cancer survivors (Dr. Barbara Parker). This knowledgeable and skilled team will enable Dr. Hartman to successfully accomplish the proposed K07 and use that experience to build an innovative research career focused on biological mechanisms of how physical activity influences neuropsychological outcomes and cognitive complaints in cancer survivors. The support provided by this K07 award, the proposed training activities, and research project described in this proposal complement Dr. Hartman's previous experience and provide an exceptional opportunity for her to broaden her research focus and transition to a career as an independent investigator.