Physical Activity and neuropsychological outcomes in a cancer population

描述（由申请人提供）：本K07提案详细介绍了培训活动，指导和研究项目的综合计划，将为申请人（Sheri Hartman博士）提供支持，知识和技能，以启动作为独立调查员的职业生涯。培训和研究活动将侧重于癌症幸存者的身体活动、神经心理结果、生活质量和相关生物学机制。哈特曼博士将对被诊断为乳腺癌的女性进行为期3个月的体育活动干预随机对照试验，以实现以下目标：探讨体育活动干预对乳腺癌幸存者神经心理结果变化的影响。探讨体育活动干预对乳腺癌幸存者认知抱怨改变的影响。研究体力活动与神经心理测试和认知疾病变化之间潜在联系的生物学机制。80名久坐不动的乳腺癌幸存者将在基线和3个月时接受加速度计测量的身体活动、神经心理测试、认知抱怨测量、空腹抽血和心理测量。为了解决主要目标和次要目标，哈特曼博士将测试，与对照组相比，参加体育锻炼组的女性在神经心理测试方面是否会有统计学上的显著改善，在认知抱怨方面是否会有所减少。为了解决第三个目标，Hartman博士将测试生物测量（BDNF, IGF-1, HOMA-IR， CRP）的变化是否完全或部分解释了体育活动干预对神经心理测试和认知疾病变化的影响。为了成功地实现提案的目标，哈特曼博士在她以前的培训基础上，制定了一个广泛的培训计划，并聚集了一个专家导师团队。该提案结合了哈特曼博士在研究生院的培训，专注于神经心理学结果、认知抱怨和癌症幸存者的生活质量，以及她在行为医学的博士后培训，专注于身体活动干预。虽然这项提案建立在哈特曼博士的优势之上，但它也将扩大她在几个关键领域的培训和专业知识，包括理解和将生物测量纳入行为研究。该计划有5个培训目标：培训目标#1：在将生物学措施纳入行为干预研究方面获得经验和培训。训练目标#2：获得代谢和炎症方面的训练，以了解胰岛素作用、炎症反应、身体活动和认知是如何相互关联的。培训目标#3：通过学习新的软件程序和新的统计分析技术，包括纵向数据建模和中介分析技术，进一步发展统计培训。训练目标#4：获得关于神经心理测试和认知抱怨的解释和理解的额外训练。培训目标#5：提高稿件准备和资助的技能，以及职业发展。哈特曼博士已经召集了一个由导师和顾问组成的专家团队，这样她就可以成功地实现这些目标。主要导师帕特森博士是摩尔斯加州大学圣地亚哥分校癌症中心癌症预防与控制项目的负责人，在将生物措施纳入减肥和营养干预方面有着丰富的经验。其他指导团队成员将确保哈特曼博士在代谢和炎症（Dorothy Sears博士）、生物统计学（Loki Natarajan博士）、神经心理测试和认知抱怨（Barton Palmer博士）等领域实现她的培训和研究目标。此外，一名医学肿瘤学顾问将在随机对照试验期间提供指导，该试验与招募和对乳腺癌幸存者进行干预有关（Barbara Parker博士）。这个知识渊博、技能娴熟的团队将使Hartman博士能够成功地完成K07计划，并利用这些经验建立一个创新的研究生涯，专注于体育活动如何影响癌症幸存者的神经心理结果和认知抱怨的生物学机制。K07奖所提供的支持，提议的培训活动，以及提案中描述的研究项目，补充了哈特曼博士以前的经验，并为她提供了一个特殊的机会，拓宽她的研究重点，并过渡到一个独立研究者的职业生涯。

DESCRIPTION (provided by applicant): This K07 proposal details a comprehensive program of training activities, mentorship, and research project that will provide the applicant (Sheri Hartman, PhD) with the support, knowledge, and skills to launch a career as an independent investigator. The training and research activities will focus on physical activity, neuropsychological outcomes, quality of life, and related biological mechanisms in cancer survivors. Dr. Hartman will conduct a 3-month randomized controlled trial of a physical activity intervention with women who were diagnosed with breast cancer to address the following aims: 1. To explore the effects of a physical activity intervention on changes in neuropsychological outcomes among breast cancer survivors 2.To explore the effects of a physical activity intervention on changes in cognitive complaints among breast cancer survivors 3. To examine biological mechanisms potentially linking physical activity with changes in neuropsychological testing and cognitive complaints. Eighty sedentary breast cancer survivors will be assessed at baseline and 3 months with accelerometer measured physical activity, neuropsychological testing, a measure of cognitive complaints, fasting blood draw, and psychological measures. To address the primary and secondary aims, Dr. Hartman will test whether, compared to control participants, women in the physical activity arm of the trial will experience statistically signifiant improvements in neuropsychological testing and decreases in a measure of cognitive complaints. To address the tertiary aim, Dr. Hartman will test whether changes in biological measures (BDNF, IGF-1, HOMA-IR, CRP) completely or partially explain the effect of the physical activity intervention on changes in neuropsychological tests and cognitive complaints. To successfully address the aims of the proposal, Dr. Hartman is building upon her previous training, has developed an extensive training plan, and has gathered an expert team of mentors. This proposal combines Dr. Hartman's graduate school training, focused on neuropsychological outcomes, cognitive complaints, and quality of life in cancer survivors, with her postdoctoral training in behavioral medicine, focused on physical activity interventions. While this proposal builds off of Dr. Hartman's strengths, it also will broaden her training and expertise in several key areas including understanding and incorporation of biological measures into behavioral research. The proposed plan has 5 training goals: Training goal #1: Gain experience and training in the incorporation of biological measures into behavioral intervention research. Training goal #2: Obtain training in metabolism and inflammation in order to understand how insulin action, inflammatory response, physical activity, and cognition are interrelated. Training goal #3: Further develop statistical training, by learning new software programs and new statistical analytic techniques, including modeling longitudinal data and mediation analysis techniques. Training goal #4: Acquire additional training on interpretation and understanding of neuropsychological testing and cognitive complaints. Training goal #5: Improve skills in manuscript preparation and grantsmanship, as well as career development. Dr. Hartman has gathered an expert team of mentors and consultants so that she may successfully achieve each of these goals. The primary mentor, Dr. Patterson, is the leader of the Cancer Prevention & Control Program at the Moores UCSD Cancer Center, and has considerable experience incorporating biological measures into weight loss and nutrition interventions. Other mentorship team members will ensure that Dr. Hartman achieves her training and research goals in the areas of metabolism and inflammation (Dr. Dorothy Sears), biostatistics (Dr. Loki Natarajan), and neuropsychological testing and cognitive complaints (Dr. Barton Palmer). In addition a medical oncologist consultant will provide guidance during the randomized controlled trial related to recruiting and conducting an intervention with breast cancer survivors (Dr. Barbara Parker). This knowledgeable and skilled team will enable Dr. Hartman to successfully accomplish the proposed K07 and use that experience to build an innovative research career focused on biological mechanisms of how physical activity influences neuropsychological outcomes and cognitive complaints in cancer survivors. The support provided by this K07 award, the proposed training activities, and research project described in this proposal complement Dr. Hartman's previous experience and provide an exceptional opportunity for her to broaden her research focus and transition to a career as an independent investigator.