Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research

分子发现中心 (CMD)：生物医学研究的小分子资源

• 批准号: 9102195
• 负责人: JOHN A PORCO
• 金额: $ 53.58万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9102195
• 关键词: Archives; Area; Basic Science; Biological; Biological Assay; Biology; Biomedical Research; Boston; Chemicals; Chemistry; Collaborations; Collection; Communities; Community Developments; Development; Ensure; Equipment; Equipment and supply inventories; Evaluation; Extramural Activities; Fee-for-Service Plans; Funding; Goals; Health; Human; Investments; Leadership; Libraries; Maintenance; Measures; Methodology; Methods; Modeling; Molecular; Monoclonal Antibody R24; National Institute of General Medical Sciences; Organic Chemistry; Pathway interactions; Principal Investigator; Protocols documentation; Quality Control; Recovery; Research; Research Infrastructure; Research Personnel; Resources; Scheme; Scientist; Services; Synthesis Chemistry; TNFRSF5 gene; Therapeutic; United States National Institutes of Health; Universities; University resources; Work; base; chemical resource; chemical synthesis; cheminformatics; cost; cost efficient; design; high throughput screening; improved; instrumentation; operation; outreach; professor; programs; screening; small molecule; small molecule libraries; success; therapeutic target; tool; tool development

 DESCRIPTION (provided by applicant): The goal of the proposed R24 program is the implementation of a transition plan for several legacy resources acquired during the 11-year NIGMS P50 funding period for the Center for Chemical Methodology and Library Development at Boston University (CMLD-BU). This work will support important, NIGMS-funded legacy resources that continue to be of high value to the community of researchers that NIGMS supports. Under the leadership of Professor Porco and coworkers, these materials, tools and services will continue to ensure timely, high quality and cost-efficient progress at the critical interface of synthetic chemistry and biomedical research. CMLD-BU resources have been fully integrated into the Boston University Center for Molecular Discovery (BU- CMD), a new functional center enabling translational biomedical research. This R24 transition involves the repurposing of key CMLD infrastructure and staff with the goal of supporting the continued distribution of small molecules to biological investigators and ensuring sustained access to critical pieces of instrumentation for small molecule synthesis, purification, and analysis. The Principal Investigator, Professor John Porco, and colleagues will oversee the incorporation of existing center assets to a self-sustaining, service-based center. The proposed plan involves reorganizing the center into three functional cores with a focus on achieving the following aims: Maintenance and replenishment of the CMLD-BU legacy compound collection within the Compound Synthesis Core (CSC). Continued distribution of the legacy compound collection to biological researchers for high-throughput screening (HTS) within the BU-CMD Chemical Library Consortium (CLC). Establishment of the Instrumentation Core (IC) and Purification & Curation Core (PCC) as self-sustaining, open-access cost recovery centers for use by the synthetic organic chemistry community. Design and implementation of a three-year transitional plan for self-sustainability with accompanying evaluative metrics.

 描述（由申请人提供）：拟议 R24 计划的目标是对波士顿大学化学方法学和图书馆开发中心 (CMLD-BU) 在 11 年 NIGMS P50 资助期内获得的多个遗留资源实施过渡计划。这项工作将支持 NIGMS 资助的重要遗留资源，这些资源对于 NIGMS 支持的研究人员社区仍然具有很高的价值。在 Porco 教授及其同事的领导下，这些材料、工具和服务将继续确保合成化学和生物医学研究关键领域的及时、高质量和成本效益的进展。 CMLD-BU 的资源已完全整合到波士顿大学分子发现中心 (BU-CMD)，这是一个新的功能中心，可实现转化生物医学研究。 R24 过渡涉及对关键 CMLD 基础设施和人员的重新利用，其目标是支持向生物研究人员持续分发小分子，并确保持续获取用于小分子合成、纯化和分析的关键仪器。首席研究员 John Porco 教授及其同事将监督现有中心资产整合为一个自我维持的、以服务为基础的中心。拟议的计划包括将该中心重组为三个功能核心，重点是实现以下目标： 维护和补充化合物合成核心 (CSC) 内的 CMLD-BU 遗留化合物集合。继续将遗留化合物集合分发给生物研究人员，以在 BU-CMD 化学图书馆联盟 (CLC) 内进行高通量筛选 (HTS)。建立仪器核心 (IC) 和纯化与管理核心 (PCC) 作为自我维持、开放获取的成本回收中心，供合成有机化学界使用。设计和实施自我可持续性的三年过渡计划以及随附的评估指标。