Center for Molecular Discovery (CMD): A Small Molecule Resource for Biomedical Research

 拟议的R24计划的目标是为波士顿大学化学方法和图书馆发展中心（CMLD-BU）在11年NIGMS P50资助期内获得的几个遗留资源实施过渡计划。这项工作将支持NIGMS资助的重要遗产资源，这些资源对NIGMS支持的研究人员社区仍然具有很高的价值。在Porco教授及其同事的领导下，这些材料、工具和服务将继续确保在合成化学和生物医学研究的关键界面上取得及时、高质量和具有成本效益的进展。CMLD-BU资源已完全整合到波士顿大学分子发现中心（BU-CMD），这是一个新的功能中心，可以进行转化生物医学研究。这一R24过渡涉及关键CMLD基础设施和工作人员的重新利用，目标是支持向生物研究人员持续分发小分子，并确保持续获得用于小分子合成、纯化和分析的关键仪器。首席研究员，教授约翰·波尔科，和同事们将监督现有的中心资产纳入一个自我维持，以服务为基础的中心。拟议的计划涉及将该中心重组为三个功能核心，重点是实现以下目标：在化合物合成核心（CSC）内维护和补充CMLD-BU遗留化合物收藏。继续向生物研究人员分发遗留化合物集合，以便在BU-CMD化学图书馆联盟（CLC）内进行高通量筛选（HTS）。建立仪器核心（IC）和纯化和固化核心（PCC）作为自我维持的，开放的成本回收中心，供合成有机化学界使用。设计和执行自我维持三年过渡计划，并附有评价指标。

 DESCRIPTION (provided by applicant): The goal of the proposed R24 program is the implementation of a transition plan for several legacy resources acquired during the 11-year NIGMS P50 funding period for the Center for Chemical Methodology and Library Development at Boston University (CMLD-BU). This work will support important, NIGMS-funded legacy resources that continue to be of high value to the community of researchers that NIGMS supports. Under the leadership of Professor Porco and coworkers, these materials, tools and services will continue to ensure timely, high quality and cost-efficient progress at the critical interface of synthetic chemistry and biomedical research. CMLD-BU resources have been fully integrated into the Boston University Center for Molecular Discovery (BU- CMD), a new functional center enabling translational biomedical research. This R24 transition involves the repurposing of key CMLD infrastructure and staff with the goal of supporting the continued distribution of small molecules to biological investigators and ensuring sustained access to critical pieces of instrumentation for small molecule synthesis, purification, and analysis. The Principal Investigator, Professor John Porco, and colleagues will oversee the incorporation of existing center assets to a self-sustaining, service-based center. The proposed plan involves reorganizing the center into three functional cores with a focus on achieving the following aims: Maintenance and replenishment of the CMLD-BU legacy compound collection within the Compound Synthesis Core (CSC). Continued distribution of the legacy compound collection to biological researchers for high-throughput screening (HTS) within the BU-CMD Chemical Library Consortium (CLC). Establishment of the Instrumentation Core (IC) and Purification & Curation Core (PCC) as self-sustaining, open-access cost recovery centers for use by the synthetic organic chemistry community. Design and implementation of a three-year transitional plan for self-sustainability with accompanying evaluative metrics.