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Prenatal and Early Life Predictors of Child Psychopathology

儿童精神病理学的产前和早期生命预测因素

基本信息

批准号：
9805726
负责人：
Hanna C Gustafsson
金额：
$ 18.32万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9805726
关键词：
3 year old Address Age Anti-inflammatory Anxiety Attention Behavior Biological Birth Brain Child Childhood Clinical Clinical assessments Cognitive Data Depressed mood Development Diagnostic Disease Distress E-learning Early Intervention Early identification Emotional Emotions Ethics Etiology Exposure to Family Fright Funding Future Goals Hyperactive behavior Immune Plasma Immune system Immunologic Factors Immunologics Impulsivity Infant Inflammation Inflammatory Informal Social Control Intervention Joints Lead Learning Life Link Literature Measures Mediating Mediation Mental Health Mental disorders Mentors Methods Modeling Molecular Moods Mothers National Institute of Mental Health Outcome Pathogenesis Phenotype Plant Roots Plasma Play Population Populations at Risk Positioning Attribute Pregnancy Pregnancy Trimesters Pregnant Women Process Psychoneuroimmunology Psychopathology Research Research Domain Criteria Risk Risk Factors Role Sampling Second Pregnancy Trimester Self-control as a personality trait Short-Term Memory Signal Transduction Social Adjustment Symptoms Testing Third Pregnancy Trimester Toddler Training Training Activity Translating Umbilical Cord Blood Work Writing chemokine clinical translation clinically relevant contextual factors cytokine depressive symptoms disease classification early childhood emotion regulation executive function experience immune activation improved infancy innovation maternal stress negative affect neurophysiology novel offspring prenatal prenatal health prenatal stress prevent programs prospective psychiatric symptom psychologic psychological distress receptor response responsible research conduct skills symptomatology theories

项目摘要

PROJECT SUMMARY Substantial theoretical work suggests that mental health disorders have their roots in early childhood development, and that symptoms of psychopathology are in part the result of breakdowns in self-regulatory skills that emerge early in life. Yet early predictors of emergent psychopathology, and/or trans-diagnostic phenotypes such as self- regulation, are poorly understood. Utilizing prospective data from a large sample (N=270) of mothers and their children, the current study aims to address this gap by: a) testing the hypothesis that infant negative affect (NA) undermines children's emerging executive functioning (EF), and that NA-associated deficits in EF are one mechanism through which early emotion-regulatory difficulties convey risk for psychopathology at 3 years of age (Aim 1); b) examining whether prenatal stress moderates associations among NA, EF, and psychopathology at age 3 (Aim 2); c) testing whether maternal immune activation during pregnancy and/or child immune activation in infancy mediate the association between maternal prenatal stress and child symptomatology (Aim 3). The results of this research will inform early identification and intervention. The execution of this research plan, in conjunction with the training activities described, will provide the applicant with the skills for an independent, innovative research program aimed at understanding the earliest origins of psychopathology. The training plan assists in enriching her strong background in development with more independence and more training in assessment and observation of psychopathology in childhood. Additionally, it includes strong training in psychoneuroimmunology, including the role of the immune system in psychopathology (in both the mother and child) as well as the mechanisms through which maternal immune activation during pregnancy may influence child risk for psychopathology. Thetraining objectives include:a) learning theory and methods related to the etiology, nosology, and pathogenesis of childhood psychopathology, b) becoming acquainted with clinical assessment issues and diagnostic assignment as it pertains to research application throughout childhood, c) translating her developmental expertise to clinical populations including conceptualizing developmental findings in relation to psychopathology theory and practice, d) gaining hands-on experience conducting research with clinical measures and clinically at risk populations, e) learning theory and methods related to studying the immune system and inflammation-psychopathology associations, f) better understanding the mechanisms through which maternal immune activation during pregnancy may influence the developing brain and, by extension, child risk for psychopathology, g) gaining hands-on experience collecting and analyzing relevant biological samples and learning about contemporary molecular and immunological methods for analyzing inflammatory signaling networks, and h) further training in the responsible conduct of research, including ethical considerations specific to clinical populations, and in i) research writing and dissemination as it pertains to the field of psychopathology, mental health, and psychoneuroimmunology.

项目总结