A Miniaturized Tool for Ultrasound Quantification of Periodontal Disease

牙周病超声定量的小型化工具

• 批准号: 9807257
• 负责人: Jesse Vincent Jokerst
• 金额: $ 21.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-02 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9807257
• 关键词: 3D Print; Acoustics; American; Apical; Architecture; Blinded; Cardiovascular system; Clinical; Clinical assessments; Color; Contrast Media; Data; Dental; Devices; Diagnosis; Diagnostic; Electrical Engineering; Elements; Engineering; Epithelial Attachment; Family suidae; Food; Generations; Gingiva; Goals; Gold; Health; Hemoglobin; Human; Image; Imaging Device; Imaging Phantoms; Implant; Incisor; Infection; Inflammation; Ink; Lateral; Light; Link; Maps; Measurement; Measures; Mechanics; Melanins; Methods; Microbial Biofilms; Modeling; Monitor; Optics; Oral; Oral Characters; Oral cavity; Oral health; Pain; Patients; Penetration; Performance; Periodontal Diseases; Periodontal Pocket; Periodontitis; Positioning Attribute; Procedures; Quality of life; Reference Standards; Reproducibility; Research; Resolution; Scanning; Signal Transduction; Slice; Squid; Structure of gingival sulcus; System; Techniques; Testing; Thick; Time; Tissues; Tooth structure; Toothache; Transducers; Ultrasonography; Variant; Work; base; bone; clinically significant; compliance behavior; deoxyhemoglobin; design; digital; imaging approach; improved; innovation; insight; miniaturize; nanoparticle; novel; peri-implantitis; photoacoustic imaging; prevent; prototype; soft tissue; tool

PROJECT SUMMARY The objective of this proposal is a small (ink pen-sized) tool that non-invasively measures dental pocket depths and assesses gingival health using ultrasound. We are motivated by studies showing that dental pain dramatically decreases quality of life but that nearly 50% of Americans have some form of periodontitis. Our scientific premise is that the current approach to measuring pocket depths is painful and imprecise with coefficients of variation as high as 40%. This results in poor patient compliance and poor diagnostic insight ultimately leading to attachment loss. Therefore, less painful and more accurate diagnostic tools could improve dental health and thus overall quality of life. Our preliminary data (J. Dent. Res., 2017) used an oral rinse based on the melanin nanoparticles from food-grade squid ink to map and measure the contours of the entire periodontal pocket in swine models with novel photoacoustic imaging. We noted good correlation of these image-based measurements to non-blinded conventional probe depth measurements via Bland- Altman analysis. However, the current transducer is ~20 cm by 5 cm and can only access the incisors in humans. The goal of this research is to build a smaller prototype suitable for intraoral ultrasound imaging. The aims below describe how we will build and validate this device. Aim 1 will build the device. We will combine a single element transducer and light emitting diodes into a compact pen-like design. This will use the expertise of Dr. Jokerst in acoustics and Dr. Hall in electrical engineering. Aim 2 will characterize the performance of the device using standard reference materials (imaging phantoms). We will measure the light homogeneity, axial resolution, lateral resolution, depth of penetration, frame rate, and scan time. Aim 3 will validate the ability of this device to measure the pocket depths in an ex vivo swine model. We will irrigate the pockets with a food-grade contrast agent (squid ink melanin nanoparticles) and image the pocket and surrounding gingiva. We will compare the values created by imaging to the gold-standard probe depths collected by Dr. Koka. We will evaluate the imaging data for bias and reproducibility with both methods, and we hypothesize that depths from imaging will correlate to blinded conventional periodontal probe data (R2>0.90). This work is innovative because it will quickly (2 minutes) and non-invasively map the contours of the entire dental pocket with low variance. Our preliminary data and the expertise of the research team in engineering, imaging, and periodontology underscore the feasibility of these ideas. The clinical impact will be a more reliable and less invasive tool to monitor attachment loss—this will increase patient compliance and facilitate more comprehensive estimates of attachment loss to ultimately decrease periodontitis rates. Long-term, this oral imaging tool would have many other applications in characterizing oral soft tissue including peri-implantitis and aberrant biofilms.

项目摘要 本提案的目的是一个小（墨水笔大小）的工具，非侵入性措施牙囊 深度和评估牙龈健康使用超声波。我们的动机是研究表明， 疼痛大大降低了生活质量，但近50%的美国人患有某种形式的牙周炎。 我们的科学前提是，目前的方法来测量口袋深度是痛苦的和不精确的， 变异系数高达40%。这导致患者依从性差和诊断洞察力差 最终导致依恋丧失。因此，更少痛苦和更准确的诊断工具可以 改善牙齿健康，从而提高整体生活质量。我们的初步数据（J.登特。结果：2017年：使用口服 基于食品级鱿鱼油墨中的黑色素纳米颗粒进行冲洗，以绘制和测量 用新型光声成像技术对猪模型的整个牙周袋进行了研究。我们注意到良好的相关性 这些基于图像的测量到通过Bland的非盲常规探头深度测量， Altman分析。然而，电流传感器约为20 cm × 5 cm，仅能进入门牙， 人类本研究的目标是建立一个较小的原型，适合口腔内超声成像。 以下目标描述了我们将如何构建和验证该器械。 目标一号将建造这个装置。我们将联合收割机的单一元件传感器和发光二极管到一个 紧凑的笔式设计。这将使用声学博士Jokerst和电气博士霍尔的专业知识 工程.目标2将使用标准参考材料表征器械的性能 （成像幻影）。我们将测量光的均匀性，轴向分辨率，横向分辨率， 穿透、帧速率和扫描时间。目标3将确认该器械测量囊袋的能力 在离体猪模型中的深度。我们将用食品级造影剂（乌贼墨）冲洗囊袋 黑色素纳米颗粒）并对囊袋和周围牙龈成像。我们将比较所创造的价值 通过成像到科卡博士收集的黄金标准探测深度。我们将评估成像数据， 这两种方法的偏差和可重复性，我们假设成像的深度将与 盲法常规牙周探针数据（R2>0.90）。这项工作是创新的，因为它将很快（2 分钟）并且以低方差非侵入性地绘制整个牙囊的轮廓。我们的初步 数据和研究团队在工程，成像和牙周病学方面的专业知识强调了 这些想法的可行性。临床影响将是一种更可靠和侵入性更小的监测工具 附件丢失-这将增加患者的依从性，并有助于更全面地估计 附着丧失最终降低牙周炎发病率。从长远来看，这种口腔成像工具 在表征包括种植体周围炎和异常生物膜的口腔软组织中的许多其它应用。