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Role of Preoperative Baroreflex Sensitivity on Postoperative and Persistent Pain after Thoracic Surgery

Role of Preoperative Baroreflex Sensitivity on Postoperative and Persistent Pain after Thoracic Surgery
术前压力感受反射敏感性对胸外科术后和持续性疼痛的作用
批准号:
9809527
负责人:
WILLIAM MAIXNER
金额:
$24.15万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-06-01 至 2021-05-31

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中文摘要
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英文摘要
The primary goal of this proposal is to establish Baroreflex Sensitivity (BRS) as a biomarker for acute postoperative pain (POP) and the likelihood of persistent postoperative pain (PPP) at the 3 month postoperative timepoint in patients undergoing video-assisted thoracic surgery (VATS). Our central hypothesis is that preoperative BRS is inversely associated with the magnitude and duration of POP during postoperative days 0-2 and the likelihood of PPP at 3 months throughout the postoperative observation by influencing nociceptive processing and surgically-induced inflammation. If this central hypothesis is confirmed then future interventional studies designed to enhance BRS will be developed with the goal of optimizing perioperative outcomes.
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Behavioral Core
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