Electrochemical Paper-Based Analytical Devices for Metal Determination

项目摘要 本项目的目标是开发一种结合两种新技术的新的采样和分析系统。一个 轻型超声波取样器将与电化学纸基分析设备(EPad)配对，用于 空气中颗粒物(PM)中金属的测量。暴露于颗粒物(PM)空气污染 在全球范围内成为人类发病率和死亡率的第五大风险因素-超过 所有其他环境危害加在一起。尽管PM是许多潜在有毒物质的复杂混合物 PM中存在的化合物、过渡和重金属含量被认为在毒性中起着重要作用。 PM造成的疾病负担得到了人群暴露和感染之间强烈的流行病学联系的支持 许多形式的健康不良(例如，心血管疾病、呼吸系统疾病、神经疾病和癌症)。 尽管有这些科学联系，但人们对个人(即个人)空气污染暴露知之甚少，因为 现有的评估个人PM暴露的技术昂贵、繁琐且复杂。 此外，PM样品分析技术(特别是过渡金属和重金属)高得令人望而却步 (100美元/样品)，并需要使用中央实验室和专业工作人员。门禁传感器 科技公司的愿景是通过提供低成本、高成本的 用于量化个人接触PM毒物的性能工具，重点是金属。《环球报》 空气污染监测市场超过40亿美元；我们寻求通过颠覆性技术利用这一市场 可以彻底改变个人暴露监测的最先进水平。在第一阶段，基本分析 使用电化学纸基分析装置(EPADS)和样品处理组件的化学 已开发并演示了用于测量金属的仪器。在第二阶段，我们将开发一条产品线， 包括一个可穿戴的(静音、轻便、紧凑)空气采样器，一个用于化学分析的简化模块，以及 手机操作和通讯所必需的软件/界面；这是一种“全面分析系统”。 将简化暴露和风险评估过程，同时大幅降低成本。我们将验证 本系统通过实验室和现场研究，对照金标方法。这个项目的结果是 将是旨在渗透工业卫生研究和咨询市场的产品 环境监测，长期目标是提供低成本的消费产品。 在该项目中，我们将1)将AST的专有空气采样技术与简化的现场分析试剂盒相结合 过滤器提取和金属分析2)开发一种廉价的一次性传感器，用于快速、同时 从单个空气采样过滤器中量化多个MET-AL和3)通过以下方式证明产品的可行性 与早期商业合作伙伴进行现场测试。如果成功，我们还将有更多的产品应用 颗粒性空气污染，因为传感器范例也适用于水、土壤和食物分析。的确有 全球迫切需要对我们周围的世界进行更简单、更廉价的分析。

Project Summary The goal of this project is to develop a new sampling and analysis system combining two new technologies. A lightweight ultrasonic sampler will be paired with an electrochemical paper-based analytical device (ePAD) for measurement of metals in airborne particulate matter (PM). Exposure to particulate matter (PM) air pollution ranks as the 5th leading risk factor for human morbidity and mortality worldwide – outpacing the health risks of all other environmental hazards combined. Although PM is a complex mixture of many potentially toxic compounds, the transition and heavy metal content present in PM is thought to play a significant role in toxicity. The disease burden posed by PM is supported by strong epidemiologic links between population exposure and many forms of ill health (e.g., cardiovascular disease, respiratory disease, neurological disorders, and cancer). Despite these scientific links, little is known about individual (i.e., personal) air pollution exposures because existing technologies for assessing personal PM exposure are expensive, burdensome, and complicated. Furthermore, PM sample analysis techniques (especially for transition and heavy metals) are prohibitively high ($100s/sample) and require the use of a centralized laboratory and specialized staff. Access Sensor Technologies has a vision to change this sampling and measurement paradigm by providing low-cost, high- performance tools for quantifying personal exposure to PM toxicants, with an emphasis on metals. The global market for air pollution monitoring exceeds $4B; we seek to leverage this market with a disruptive technology than can revolutionize the state-of-the-art in personal exposure monitoring. During Phase I, the basic analytic chemistry using electrochemical paper-based analytic devices (ePADs) and sample processing componentry for measuring metals were developed and demonstrated. During Phase II, we will develop a product line that includes a wearable (silent, lightweight, compact) air sampler, a streamlined module for chemical analysis, and the software/interface necessary for mobile-phone operation and communications; this ‘total analysis system’ will streamline the process of exposure and risk assessment while dramatically lowering cost. We will validate this system through laboratory and field studies against gold-standard methods. The outcome of this project will be products designed to penetrate research and consulting markets in industrial hygiene and environmental monitoring, with a long-term goal of offering a low-cost consumer product.For this Phase II project, we will 1) Integrate AST's proprietary air sampling technology with a streamlined analytic kit for in-field filter ex-traction and metals analysis 2) Develop an inexpensive and disposable sensor for rapid, simultaneous quantification of multiple met-als from a single air sampling filter and 3) Demonstrate product viability through field testing with early-stage commercial partners. If successful, we will also have product applications beyond particulate air pollution, as the sensor paradigm is amenable for water, soil, and food analyses as well. There is an urgent global need for simpler cheaper analysis of the world around us.