Molecular Atlas of Lung Development - Data Coordinating Center

描述(由申请者提供)：肺发育分子图谱计划的总体目标是开发一份人类和小鼠肺发育的分子图谱，作为研究界独特的参考资源。我们的应用程序的目标是作为肺发育计划分子图谱(LongMAP-DCC)的数据协调中心(DCC)。我们已经采取了几种创新和具有成本效益的方法来建立LUNGMAP-DCC，这将极大地造福于研究界，并促进对分子肺发育的更多了解。我们已经建立了一个由杜克临床研究所、RTI国际公司和辛辛那提儿童医院医学中心组成的多学科研究团队来领导和运作LUNGMAP-DCC。我们正在利用两位经验丰富的研究人员作为多个PI的优势(Palmer博士和Clark博士)，我们将应用新的数据管理和生物信息学方法来为健康肺(呼吸)数据库创建生物信息学资源地图集。DCC将进行数据收集、整合和分析；开发和维护LongMAP数据库和网站；协调人体组织核心(HTC)和研究中心(RCS)的研究活动。我们将通过以下具体目标补充这些目标，以支持财团的成功：具体目标1)行政协调基础设施：DCC将作为行政基础设施，通过1)提供分子肺开发、临床设计、统计学和生物信息学方面的专业知识，促进我们的多学科团队、RC和HTC之间的合作；以及2)创建整个财团范围的优先事项和政策、沟通计划、资源目录和具体目标2)LUNGMAP门户和呼吸(健康肺的生物信息学资源图集)：DCC将通过创建和管理1)TREAGE来为LUNgMAP建立集中的数据存储库和公共界面；2)LUNGMAP网站；3)数据管理的标准操作程序；4)现有的肺发育结果；5)肺发育、结构和跨物种比较的本体论；6)来自RCS的实验数据和来自HTC的生物样本数据；以及7)用于分析实验数据的新工具。这一应用利用了多学科研究团队的互补优势，他们拥有肺部临床专业知识、对肺分子发育的基本了解、多中心研究网络的成功领导以及深入的计算机编程、数据库开发和生物信息学技能，这些技能将创建一个高度功能、集成的、公共可访问的平台，将促进对RCS和HTC生成的数据的分析，以促进我们对分子肺发育的理解。(摘要结束)

DESCRIPTION (provided by applicant): The overall objective of the Molecular Atlas of Lung Development Program (LungMAP) is to develop a molecular atlas of the developing lung from human and mouse to serve as a unique reference resource for the research community. The objective of our application is to serve as the Data Coordinating Center (DCC) for the Molecular Atlas of Lung Development Program (LungMAP-DCC). We have taken several innovative and cost-effective approaches to build the LungMAP-DCC that will greatly benefit the research community and promote a greater understanding of molecular lung development. We have created a multi-disciplinary team of investigators from Duke Clinical Research Institute, RTI International, and Cincinnati Children's Hospital Medical Center to lead and operationalize the LungMAP-DCC. We are leveraging the strengths of two highly experienced investigators as multiple PIs (Drs. Palmer and Clark) and we will apply novel data management and bioinformatics approaches to create the Bioinformatics REsource ATlas for the Healthy lung (BREATH) database. The DCC will perform data collection, integration, and analysis; develop and maintain the LungMAP database and website; and coordinate research activities of the Human Tissue Core (HTC) and the Research Centers (RCs). We will complement these goals with the following Specific Aims that support the success of consortium: Specific Aim 1) Administrative Coordinating Infrastructure: The DCC will serve as the administrative infrastructure that facilitates collaboration among our multidisciplinary team, RC, and the HTC by 1) providing expertise in molecular lung development, clinical design, statistics, and bioinformatics; and 2) the creation of consortium-wide priorities and policies, communication plan, and resource catalog and Specific Aim 2) LungMAP Portal and BREATH (Bioinformatics REsource ATlas for the Healthy lung): The DCC will build the centralized data repository and public interface for LungMAP by creating and managing 1) BREATH; 2) LungMAP Website; 3) standard operating procedures for data management; 4) existing lung development results; 5) ontologies for lung development, structures, and cross species comparisons; 6) experimental data from RCs and biologic sample data from the HTC; and 7) novel tools to analyze the experimental data. This application leverages the complementary strengths of multi-disciplinary research teams with clinical pulmonary expertise, basic understanding of lung molecular development, successful leadership of multicenter research networks, and in-depth computer programing, database development, and bioinformatics skills that will create a highly functional, integrated, publically accessible platform that will facilitate analysis of data generated by the RCs and HTC to advance our understanding of molecular lung development. (End of Abstract)