A Single-Sided Magnetic Particle Imaging Scanner for In Vivo Breast Cancer Imaging

用于体内乳腺癌成像的单面磁粒子成像扫描仪

• 批准号: 9812008
• 负责人: Alexey A Tonyushkin
• 金额: $ 16.81万
• 依托单位: UNIVERSITY OF MASSACHUSETTS BOSTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-03 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9812008
• 关键词: 3D Print; Address; Agreement; Algorithms; Angiography; Animals; Applications Grants; Area; Automation; Blood capillaries; Breast; Breast Cancer Detection; Breast biopsy; Calibration; Clinical; Clinical Research; Computer Interface; Computers; Consumption; Detection; Devices; Diagnostic; Diagnostic Imaging; Diagnostic Procedure; Engineering; Environment; Geometry; Goals; Grant; Height; Hospitals; Human; Human body; Hyperthermia; Image; Imaging Device; Imaging Phantoms; Imaging Techniques; Imaging technology; Inflammation; Ionizing radiation; Lymphatic System; Magnetic Resonance Imaging; Magnetic nanoparticles; Magnetism; Mammary Neoplasms; Measures; Medical Imaging; Methods; Modification; Motor; Mus; Noise; Organ; Penetration; Performance; Population; Procedures; Research; Resolution; Rodent; Rotation; Safety; Screening procedure; Sentinel Lymph Node Biopsy; Side; Signal Transduction; Source; Staging; Surface; System; Testing; Therapeutic Intervention; Three-Dimensional Imaging; Tracer; Translating; Translations; Validation; Women' s Health; Work; base; cancer imaging; clinical application; clinical practice; clinical translation; clinically relevant; data acquisition; design; image reconstruction; imager; imaging modality; imaging study; imaging system; improved; in vivo; in vivo imaging; interest; iron oxide nanoparticle; magnetic field; malignant breast neoplasm; nanoparticle; novel; particle; portability; programs; prototype; scale up; simulation; spatiotemporal; tomography; tool; tumor; undergraduate student

Magnetic Particle Imaging (MPI) is an emerging non-invasive tomographic imaging modality; like CT or MRI, it could be applied in clinical and research settings as a safe diagnostic technique, but without ionizing radiation or toxic tracers. One of the major MPI challenges toward clinical translation has been the ability to scale up the coils to surround a human body while being able to generate and drive the sufficiently strong magnetic field gradient required for high spatial resolution. These requirements, however, demand prohibitively high power consumption in a device with cylindrical geometry; therefore, alternative topologies, such as an open geometry scanner, would be highly desirable. The goal of this proposal is to develop a novel single-sided MPI imager and demonstrate in vivo cancer imaging in rodents. The single-sided device has all the hardware on one side of the imaging volume; therefore, such a device can be used equally well on small animals and humans for multidimensional diagnostic imaging and as an MPI spectrometer (MPS). In our unique approach, we will develop a single-sided MPI imager with much more promising field topology, namely, field-free line (FFL) as opposed to the more common and relatively easier to implement field-free point (FFP) geometry, for a potential 10-fold increase of SNR, more robust image reconstruction, and larger field of view. To date, we have built a first prototype of a single-sided coils assembly with the FFL geometry that consists of all the required coils in a unilateral configuration. The measured magnetic field showed perfect agreement with the simulations. We further validated our device by demonstrating magnetic particle signal detection using a point-source phantom. Developing a fully capable multidimensional scanner based on single-sided geometry has direct clinical relevance in breast cancer imaging. We pursue two specific aims: 1) Develop a multidimensional imaging technique, which can be implemented in our single-sided device. The main objectives of this aim are to drastically increase the sensitivity of the device and identify an imaging sequence that combines both selection and excitation coils and works in tandem with our unique surface-coil receive approach. We will implement the required hardware modification and signal automation. 2) Validate the imaging method by obtaining the MPI images. The performance of the MPI scanner will be analyzed using phantoms with iron oxide nanoparticles. Finally, we will validate the scanner performance in in vivo imaging of breast tumor-bearing mice. The overall strength of the proposed research lies in developing the first ever MPI scanner that could potentially be translated to clinical settings. Specifically, we hope to deliver a more sensitive and non-invasive tool for breast cancer screening that has a direct impact on women health.

磁粒子成像（MPI）是一种新兴的非侵入性断层成像模式;与CT或MRI一样，它 可以作为一种安全的诊断技术应用于临床和研究环境，但没有电离辐射 或有毒示踪剂。MPI对临床翻译的主要挑战之一是扩大 同时能够产生并驱动足够强的磁场 高空间分辨率所需的梯度。然而，这些要求需要过高的功率 因此，替代拓扑结构，例如开放式几何结构， 扫描仪，这将是非常可取的。本计画的目标是发展一种新颖的单面多光子干涉成像器 并在啮齿类动物中展示体内癌症成像。单面设备将所有硬件放在一面 因此，这种装置可以同样很好地用于小动物和人类， 多维诊断成像和MPI光谱仪（MPS）。在我们独特的方法中，我们将 开发具有更有前途的场拓扑结构的单侧MPI成像器，即无场线（FFL）， 相对于更常见且相对更容易实现的无场点（FFP）几何形状， 10-SNR成倍增加，图像重建更稳健，视野更大。 到目前为止，我们已经建立了第一个具有FFL几何形状的单面线圈组件原型，包括 所有需要的线圈都在单侧配置中。测得的磁场与 模拟。我们进一步验证了我们的设备，通过演示磁性粒子信号检测使用 点源体模开发基于单面几何的全功能多维扫描仪 在乳腺癌成像中具有直接的临床相关性。我们追求两个具体目标：1）开发一个 多维成像技术，可以在我们的单面设备中实现。主要 该目标的目的是显著增加设备的灵敏度 它结合了选择线圈和激励线圈，并与我们独特的表面线圈接收器协同工作。 approach.我们将实施所需的硬件改造和信号自动化。2)验证 通过获得MPI图像的成像方法。MPI扫描仪的性能将使用 铁氧化物纳米颗粒的phantomy。最后，我们将验证扫描仪在体内成像中的性能， 乳腺肿瘤小鼠。 拟议研究的整体优势在于开发有史以来第一台MPI扫描仪， 可能会转化为临床环境。具体来说，我们希望提供一个更敏感和非侵入性的 乳腺癌筛查工具，对妇女健康有直接影响。