A Single-Sided Magnetic Particle Imaging Scanner for In Vivo Breast Cancer Imaging

用于体内乳腺癌成像的单面磁粒子成像扫描仪

• 批准号: 10485437
• 负责人: Alexey A Tonyushkin
• 金额: $ 25.72万
• 依托单位: OAKLAND UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-09 至 2023-09-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10485437
• 关键词: Single; Sided; Magnetic; Particle; Imaging

Magnetic Particle Imaging (MPI) is an emerging non-invasive tomographic imaging modality; like CT or MRI, it could be applied in clinical and research settings as a safe diagnostic technique, but without ionizing radiation or toxic tracers. One of the major MPI challenges toward clinical translation has been the ability to scale up the coils to surround a human body while being able to generate and drive the sufficiently strong magnetic field gradient required for high spatial resolution. These requirements, however, demand prohibitively high power consumption in a device with cylindrical geometry; therefore, alternative topologies, such as an open geometry scanner, would be highly desirable. The goal of this proposal is to develop a novel single-sided MPI imager and demonstrate in vivo cancer imaging in rodents. The single-sided device has all the hardware on one side of the imaging volume; therefore, such a device can be used equally well on small animals and humans for multidimensional diagnostic imaging and as an MPI spectrometer (MPS). In our unique approach, we will develop a single-sided MPI imager with much more promising field topology, namely, field-free line (FFL) as opposed to the more common and relatively easier to implement field-free point (FFP) geometry, for a potential 10-fold increase of SNR, more robust image reconstruction, and larger field of view. To date, we have built a first prototype of a single-sided coils assembly with the FFL geometry that consists of all the required coils in a unilateral configuration. The measured magnetic field showed perfect agreement with the simulations. We further validated our device by demonstrating magnetic particle signal detection using a point-source phantom. Developing a fully capable multidimensional scanner based on single-sided geometry has direct clinical relevance in breast cancer imaging. We pursue two specific aims: 1) Develop a multidimensional imaging technique, which can be implemented in our single-sided device. The main objectives of this aim are to drastically increase the sensitivity of the device and identify an imaging sequence that combines both selection and excitation coils and works in tandem with our unique surface-coil receive approach. We will implement the required hardware modification and signal automation. 2) Validate the imaging method by obtaining the MPI images. The performance of the MPI scanner will be analyzed using phantoms with iron oxide nanoparticles. Finally, we will validate the scanner performance in in vivo imaging of breast tumor-bearing mice. The overall strength of the proposed research lies in developing the first ever MPI scanner that could potentially be translated to clinical settings. Specifically, we hope to deliver a more sensitive and non-invasive tool for breast cancer screening that has a direct impact on women health.

磁粒子成像（MPI）是一种新兴的非侵入性断层成像模式;如 CT或MRI，它可以作为一种安全的诊断技术应用于临床和研究环境，但 没有电离辐射或有毒示踪剂。MPI临床应用面临的主要挑战之一 这种转换是将线圈按比例放大以包围人体的能力， 为了产生和驱动足够强的磁场梯度， 分辨率然而，这些要求在通信系统中要求过高的功耗。 具有圆柱形几何形状的设备;因此，替代拓扑结构，例如开放式几何形状 扫描仪，这将是非常可取的。这项提案的目标是开发一种新颖的单面 MPI成像仪和演示在啮齿动物体内癌症成像。单面设备具有所有 成像体积一侧的硬件;因此，可以同等地使用这种设备 以及对小动物和人类进行多维诊断成像和作为MPI 光谱仪（MPS）。在我们独特的方法中，我们将开发一种单面MPI成像仪， 更有前途的场拓扑，即无场线（FFL），而不是更常见的 并且相对更容易实现无场点（FFP）几何， 10-SNR成倍增加，图像重建更稳健，视野更大。 到目前为止，我们已经建立了第一个原型的单面线圈组件与FFL几何 其由单侧配置中的所有所需线圈组成。所测量的磁场 与模拟结果完全吻合我们进一步验证了我们的设备， 使用点源模型的磁粒子信号检测。开发一个完全有能力的 基于单侧几何结构的多维扫描仪在乳腺中具有直接的临床相关性 癌症成像我们追求两个具体目标：1）开发多维成像技术， 这可以在我们的单侧设备中实现。这一目标的主要目标是 大大增加了设备的灵敏度，并确定了一个成像序列， 选择和激励线圈，并与我们独特的表面线圈接收串联工作 approach.我们将实施所需的硬件改造和信号自动化。（二） 通过获得MPI图像，验证了成像方法。MPI扫描仪的性能 将使用具有氧化铁纳米颗粒的Phantom进行分析。最后，我们将验证扫描仪 在携带乳腺肿瘤的小鼠的体内成像中的性能。 拟议研究的整体优势在于开发有史以来第一台MPI扫描仪， 可能会转化为临床应用。具体来说，我们希望提供更敏感的 乳腺癌筛查的非侵入性工具，对妇女健康有直接影响。