Improving Melanoma Diagnosis with Pump-Probe Optical Imaging

利用泵浦探针光学成像改善黑色素瘤的诊断

• 批准号: 9189685
• 负责人: Warren S Warren
• 金额: $ 32.14万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-02 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9189685
• 关键词: Age; Algorithmic Analysis; Algorithms; Archives; Biochemical Pathway; Biological Assay; Biopsy; Categories; Chemicals; Classification; Clinical; Color; Databases; Detection; Diagnosis; Diagnostic; Disease; Employee Strikes; Entropy; Excision; Eye; Gender; Goals; Gold; Grant; Health Care Costs; Hematoxylin and Eosin Staining Method; Heterogeneity; Histopathology; Image; Image Analysis; Imaging technology; Immunohistochemistry; Italy; Lasers; Lead; Lesion; Malignant Neoplasms; Medical; Melanins; Melanosomes; Methods; Microscope; Microscopy; Mole the mammal; Molecular; Morbidity - disease rate; Morphology; Neoplasm Metastasis; Nevus; Outcome; Pathologist; Patient Care; Patient-Focused Outcomes; Patients; Pigments; Principal Component Analysis; Protocols documentation; Publishing; Pump; Research; Resolution; Retrospective Studies; Sampling; Savings; Sentinel Lymph Node Biopsy; Skin; Slide; Spatial Distribution; Staging; Staining method; Stains; System; Testing; Text; Thick; Thinness; Time; Tissues; Translational Research; United States National Institutes of Health; Validation; Variant; Woman; Work; base; cancer biomarkers; cancer diagnosis; cost; diagnostic accuracy; eumelanin; imaging modality; improved; in vivo; insight; male; melanoma; men; mortality; novel; optical imaging; pheomelanin; predict clinical outcome; public health relevance; skin lesion; translational medicine; two-photon

DESCRIPTION (provided by applicant): The goal of the research is to use a pump-probe microscopy system to find statistically significant variations between melanomas that did and did not develop metastases. This information will be used to develop automated classification algorithms to find robust molecular and structural features with strong predictive power. These insights will enable a retrospective study of melanoma and sentinel node biopsies, that can be used to validate the findings. By the end of the project, it is expected that there will be statistically significant evidence that pump-probe microscopy can substantially improve the diagnostic accuracy of histopathology.

描述（由申请人提供）：该研究的目标是使用泵探针显微镜系统来发现发生和未发生转移的黑色素瘤之间在统计上显着的差异。这些信息将用于开发自动分类算法，以找到具有强大预测能力的稳健分子和结构特征。这些见解将使黑色素瘤和前哨淋巴结活检的回顾性研究成为可能，可用于验证研究结果。到项目结束时，预计将有统计上显着的证据表明泵探针显微镜可以大大提高组织病理学的诊断准确性。

项目成果

Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump–Probe Microscopy

使用泵探针显微镜分析结膜黑素细胞病变中的黑色素结构和生化成分

• DOI: 10.1167/tvst.8.3.33
• 发表时间: 2019
• 期刊: Translational Vision Science & Technology
• 影响因子: 3
• 作者: Robles, Francisco E.;Deb, Sanghamitra;Vajzovic, Lejla;Vora, Gargi K.;Mruthyunjaya, Prithvi;Warren, Warren S.
• 通讯作者: Warren, Warren S.