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Improving Melanoma Diagnosis with Pump-Probe Optical Imaging

Improving Melanoma Diagnosis with Pump-Probe Optical Imaging
利用泵浦探针光学成像改善黑色素瘤的诊断
批准号：
9189685
负责人：
Warren S Warren
金额：
$32.14万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
项目状态：
已结题
起止时间：
2013-01-02 至 2017-12-31
来源：
https://reporter.nih.gov/project-details/9189685
关键词：
AgeAlgorithmic AnalysisAlgorithmsArchivesBiochemical PathwayBiological AssayBiopsyCategoriesChemicalsClassificationClinicalColorDatabasesDetectionDiagnosisDiagnosticDiseaseEmployee StrikesEntropyExcisionEyeGenderGoalsGoldGrantHealth Care CostsHematoxylin and Eosin Staining MethodHeterogeneityHistopathologyImageImage AnalysisImaging technologyImmunohistochemistryItalyLasersLeadLesionMalignant NeoplasmsMedicalMelaninsMelanosomesMethodsMicroscopeMicroscopyMole the mammalMolecularMorbidity - disease rateMorphologyNeoplasm MetastasisNevusOutcomePathologistPatient CarePatient-Focused OutcomesPatientsPigmentsPrincipal Component AnalysisProtocols documentationPublishingPumpResearchResolutionRetrospective StudiesSamplingSavingsSentinel Lymph Node BiopsySkinSlideSpatial DistributionStagingStaining methodStainsSystemTestingTextThickThinnessTimeTissuesTranslational ResearchUnited States National Institutes of HealthValidationVariantWomanWorkbasecancer biomarkerscancer diagnosiscostdiagnostic accuracyeumelaninimaging modalityimprovedin vivoinsightmalemelanomamenmortalitynoveloptical imagingpheomelaninpredict clinical outcomepublic health relevanceskin lesiontranslational medicinetwo-photon

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中文摘要
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英文摘要
DESCRIPTION (provided by applicant): The goal of the research is to use a pump-probe microscopy system to find statistically significant variations between melanomas that did and did not develop metastases. This information will be used to develop automated classification algorithms to find robust molecular and structural features with strong predictive power. These insights will enable a retrospective study of melanoma and sentinel node biopsies, that can be used to validate the findings. By the end of the project, it is expected that there will be statistically significant evidence that pump-probe microscopy can substantially improve the diagnostic accuracy of histopathology.
期刊论文(20)
专著(0)
科研奖励(0)
会议论文
Analysis of Melanin Structure and Biochemical Composition in Conjunctival Melanocytic Lesions Using Pump–Probe Microscopy
使用泵探针显微镜分析结膜黑素细胞病变中的黑色素结构和生化成分
DOI： 10.1167/tvst.8.3.33
发表时间： 2019
期刊： Translational Vision Science & Technology
影响因子： 3
作者： [Robles, Francisco E., Deb, Sanghamitra, Vajzovic, Lejla, Vora, Gargi K., Mruthyunjaya, Prithvi, Warren, Warren S.]
通讯作者： Warren, Warren S.
Improving Melanoma Diagnosis with Pump-Probe Optical Imaging
  • 批准号：
    8437772
  • 项目类别：
  • 资助金额：
    $32.14万
  • 财政年份：
    2013
  • 负责人：
    Warren S Warren
  • 依托单位：
    DUKE UNIVERSITY
Improving Melanoma Diagnosis with Pump-Probe Optical Imaging
  • 批准号：
    8776278
  • 项目类别：
  • 资助金额：
    $32.14万
  • 财政年份：
    2013
  • 负责人：
    Warren S Warren
  • 依托单位：
    DUKE UNIVERSITY
Improving Melanoma Diagnosis with Pump-Probe Optical Imaging
  • 批准号：
    8601919
  • 项目类别：
  • 资助金额：
    $31.17万
  • 财政年份：
    2013
  • 负责人：
    Warren S Warren
  • 依托单位：
    DUKE UNIVERSITY
Improving Melanoma Diagnosis with Pump-Probe Optical Imaging
  • 批准号：
    8978295
  • 项目类别：
  • 资助金额：
    $32.14万
  • 财政年份：
    2013
  • 负责人：
    Warren S Warren
  • 依托单位：
    DUKE UNIVERSITY
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