利用泵浦探针光学成像改善黑色素瘤的诊断-猫眼课题宝

利用泵浦探针光学成像改善黑色素瘤的诊断

批准号：

8978295

负责人：

Warren S Warren

金额：

$32.14万

依托单位：

DUKE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-01-02 至 2017-12-31

来源：

https://reporter.nih.gov/project-details/8978295

关键词：

Address Age Algorithms Archives Biochemical Pathway Biological Assay Biopsy Categories Chemicals Classification Clinical Color Databases Detection Diagnosis Diagnostic Disease Employee Strikes Entropy Excision Eye Gender Goals Gold Grant Health Health Care Costs Hematoxylin and Eosin Staining Method Heterogeneity Histopathology Image Image Analysis Imaging technology Immunohistochemistry Lasers Lead Lesion Malignant Neoplasms Medical Melanins Melanosomes Methods Microscope Microscopy Mole the mammal Molecular Morbidity - disease rate Morphology Neoplasm Metastasis Nevus Outcome Pathologist Patient Care Patient-Focused Outcomes Patients Pigments Principal Component Analysis Protocols documentation Publishing Pump Research Resolution Retrospective Studies Sampling Science Sentinel Lymph Node Biopsy Skin Slide Spatial Distribution Staging Staining method Stains System Testing Text Thick Time Tissues United States National Institutes of Health Validation Variant Woman Work base cancer biomarkers cancer diagnosis cost diagnostic accuracy eumelanin falls imaging modality improved in vivo insight male melanoma men mortality novel optical imaging pheomelanin predict clinical outcome skin lesion translational medicine two-photon

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中文摘要

翻译

描述（由申请人提供）：本研究的目的是使用泵-探针显微镜系统来发现发生转移和未发生转移的黑色素瘤之间的统计学显著差异。这些信息将用于开发自动分类算法，以找到具有强大预测能力的强大分子和结构特征。这些见解将使黑色素瘤和前哨淋巴结活检的回顾性研究，可用于验证发现。到项目结束时，预计将有统计学上的显著证据表明，泵-探针显微镜可以大大提高组织病理学的诊断准确性。

英文摘要

DESCRIPTION (provided by applicant): The goal of the research is to use a pump-probe microscopy system to find statistically significant variations between melanomas that did and did not develop metastases. This information will be used to develop automated classification algorithms to find robust molecular and structural features with strong predictive power. These insights will enable a retrospective study of melanoma and sentinel node biopsies, that can be used to validate the findings. By the end of the project, it is expected that there will be statistically significant evidence that pump-probe microscopy can substantially improve the diagnostic accuracy of histopathology.

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