Center for Appalachian Research in Environmental Sciences

阿巴拉契亚环境科学研究中心

• 批准号: 9270969
• 负责人: Xianglin Shi
• 金额: $ 149.65万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9270969
• 关键词: Address; Air; Analytical Chemistry; Appalachian Region; Area; Arsenic; Asthma; Atherosclerosis; Awareness; Bioinformatics; Chemicals; Child health care; Chromium; Chronic Disease; Chronic Obstructive Airway Disease; Clinical; Collaborations; Colorectal Cancer; Communication; Communities; Community Outreach; Complex; Computational Biology; Core Facility; Development; Diabetes Mellitus; Disease; Ecology; Environment; Environmental Health; Environmental Risk Factor; Exposure to; Fostering; Foundations; Funding; Genetic Predisposition to Disease; Goals; Health; Health Professional; Health Sciences; Healthcare; Heart; Heart Diseases; Heavy Metals; Human; Incidence; Individual; Integrative Medicine; Interest Group; Kentucky; Leadership; Longevity; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medical center; Mentorship; Metabolic Diseases; Mining; National Institute of Environmental Health Sciences; Nickel; Obesity; Outcome; Particulate; Pilot Projects; Population; Positioning Attribute; Public Health; Pulmonary Heart Disease; Radon; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Rivers; Rural; Science; Scientist; Stimulus; Structure; Talents; Toxic Environmental Substances; Toxicology; Training; Training Activity; Translations; Universities; Vision; Water; base; career; career development; early life exposure; innovation; interest; member; metabolomics; neonate; novel; population health; programs; socioeconomic disadvantage; water quality

PROJECT SUMMARY – Overall The University of Kentucky Center for Appalachian Research in Environmental Sciences (UK-CARES) will establish an Environmental Health Sciences Core Center to enhance research capacity focused on major environmental health impacts to air and water quality that have been implicated in environmentally induced disease. This Center will provide advanced infrastructure and leading expertise, dedicated career development and mentorship, and community-engaged interactions to facilitate innovative discovery and new understandings of environmental factors in disease initiation, progression, and outcomes and their community impacts. The central hypothesis is that toxic environmental agents are contributors to the disproportionately high incidence of chronic diseases, e.g., cancers, cardiopulmonary disease, and metabolic disorders in Appalachian Kentucky and that the impacts of early exposure are especially harmful. UK-CARES draws on a strong and diverse base of environmental health science and community-engaged research to build environmental health research capacity to meet the needs of communities in three Area Development Districts in southeastern Kentucky: Big Sandy, Kentucky River, and Cumberland Valley. Center members bring notable strengths in environmental health across four Research Interest Groups: Cardiopulmonary Diseases, Metabolic Disorders, Cancer, and Child Health and Early Life Exposures. To achieve the Center’s goal, UK-CARES will: 1) establish a rich research environment and a framework for transdisciplinary leadership and integrated infrastructure to facilitate collaboration and efficient use of resources for research expansion and development of new scientific directions; 2) build research capacity in environmental health sciences by providing an outstanding intellectual environment and advanced infrastructure to support innovation and community engagement; 3) recruit new talent and facilitate career development of investigators whose research addresses critical issues in environmentally induced disease through mentorship and structured career training activities; 4) develop multi-directional and mutually beneficial communications and interactions with community residents, policymakers, and public health/healthcare professionals to identify environmental concerns of target communities as a stimulus to new research; and 5) bridge the gap between discovery of novel research findings and population-level awareness and practice via community-focused science communication training. An Integrative Health Sciences Facility Core, Analytical Core, and Community Outreach and Engagement Core are integral to this effort and will catalyze multi-directional translation across the whole spectrum of research; provide advanced analytical support in metabolomics, computational biology, analytical chemistry, biospecimen management, and bioinformatics; and bridge Center and community priorities. Complementary activities in career development of scientists who are interested in tackling challenging environmental health questions and pilot project funding will support developing research and evolving scientific directions.

项目总结--总体 肯塔基大学阿巴拉契亚环境科学研究中心(UK-CARE)将 建立环境健康科学核心中心，增强重点学科研究能力 环境引起的对空气和水质量的环境健康影响 疾病。该中心将提供先进的基础设施和领先的专业知识，致力于职业发展 和指导，以及社区参与的互动，以促进创新发现和新的理解 疾病发生、发展和结果中的环境因素及其对社区的影响。这个 中心假设是有毒的环境因素是导致不成比例的高发病率的原因 阿巴拉契亚肯塔基州的慢性疾病，如癌症、心肺疾病和代谢紊乱 早期接触的影响尤其有害。英国CARE拥有强大而多样化的基础 环境健康科学和社区参与的研究，以建立环境健康研究 肯塔基州东南部三个地区开发区满足社区需求的能力：BIG 桑迪、肯塔基河和坎伯兰河谷。中心成员在环境方面带来显著优势 四个研究兴趣组的健康：心肺疾病、代谢紊乱、癌症和 儿童健康与早期生活暴露。为了实现中心的目标，英国-CARE将：1)建立一个富有的 研究环境和跨学科领导框架以及综合基础设施 协作和有效利用资源，以扩大研究和开发新的科学方向； 2)通过提供优秀的智力环境，建设环境健康科学的研究能力 和先进的基础设施，以支持创新和社区参与；3)招聘新人才和 促进研究人员的职业发展，他们的研究涉及环境领域的关键问题 通过辅导和有组织的职业培训活动诱发疾病；4)发展多方向和 与社区居民、政策制定者和公众进行互利的沟通和互动 健康/医疗保健专业人员确定目标社区的环境问题，以刺激新的 研究；以及5)弥合新研究发现和人口层面意识之间的差距 并通过以社区为中心的科学交流培训进行实践。一个综合性的健康科学设施 核心、分析核心以及社区外展和参与核心是这一努力和意愿不可或缺的部分 在整个研究范围内催化多方向翻译；提供高级分析 支持代谢组学、计算生物学、分析化学、生物样品管理，以及 生物信息学；桥梁中心和社区优先事项。职业发展中的补充活动 对解决具有挑战性的环境健康问题和试点项目资金感兴趣的科学家将 支持开展研究和发展科学方向。