Program 4: Cancer Prevention and Control Program (CPC)

计划 4：癌症预防和控制计划 (CPC)

• 批准号: 9315741
• 负责人: H-H. Sherry CHOW
• 金额: $ 0.1万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315741
• 关键词: Address; Advanced Malignant Neoplasm; Area; Arizona; Behavioral; Biological Factors; Biological Markers; Breast; Cancer Burden; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Control Research; Cancer Survivorship; Catchment Area; Chemoprevention; Clinical Research; Collaborations; Colorectal Cancer; Education and Outreach; Ensure; Environmental Risk Factor; Epidemiology; Faculty; Fostering; Funding; Goals; Grant; Incidence; International; Intervention; Knowledge; Laboratory Research; Malignant Neoplasms; Malignant neoplasm of prostate; Manuscripts; Morbidity - disease rate; Nutraceutical; Outcome; Ovarian; Peer Review; Pharmacologic Substance; Plant Roots; Primary Prevention; Quality of life; Research; Research Activity; Research Personnel; Resource Sharing; Resources; Risk; Science; Scientific Advances and Accomplishments; Secondary Prevention; Secure; Skin Cancer; Strategic Planning; Students; Testing; Time; Translational Research; Treatment outcome; Universities; Vaccines; Woman; Work; behavior test; cancer epidemiology; cancer prevention; cancer risk; cancer site; cancer type; design; gene environment interaction; improved; lifestyle factors; member; mortality; multidisciplinary; named group; novel chemoprevention; programs; psychosocial; research study; synergism; tertiary prevention

Project Summary / Abstract: Cancer Prevention and Control Program (CPC) The scientific goal of the Cancer Prevention and Control Program (CPC) at the University of Arizona Cancer Center (UACC) is to develop and implement highly interactive, multidisciplinary cancer prevention and control research, training, and outreach that will lead to progressive reductions in cancer incidence, morbidity, and mortality. The CPC fosters high impact, interactive, multidisciplinary and translational science, as well as training and outreach, that serves the catchment area of southern Arizona. Program activities are organized under three major themes: Theme 1) Cancer Epidemiology; Theme 2) Chemoprevention and Biomarkers; Theme 3) Behavioral, Psychosocial, and Quality of Life. The CPC has three Specific Aims that are aligned with these themes: Aim 1) To advance cancer prevention knowledge and inform on interventions through epidemiological science focused on biological, environmental, and lifestyle factors as well as gene- environment interactions associated with cancer risk, morbidity, and mortality; Aim 2) To evaluate novel chemoprevention compounds and biomarkers that will impact cancer prevention through focus on pharmaceuticals, nutraceuticals, and vaccines; and Aim 3) To test behavioral, psychosocial, and quality of life targeted interventions with high potential to reduce risk and improve cancer outcomes. Researchers operationalize their efforts through interdisciplinary teams largely organized by cancer type to integrate cutting- edge research activities across the continuum of cancer prevention and control and to address special populations and cancer burdens in the catchment area. The Program has 61 Members that span 21 academic departments. The Leaders of the Program utilize extensive strategic planning engaging faculty, students, and Shared Resource Directors to ensure that the Members of the Program have timely access to the resources and scientific approaches needed to advance their research goals. As of September 1, 2015, the CPC Program secured $17M in total annual grant dollars with $7.3M of that from NCI and $6.4M in other peer- reviewed funding. CPC Members contributed to 570 cancer-relevant manuscripts, of which 37% were intra- programmatic and 22% were inter-programmatic. The ability to achieve the scientific goals of the CPC Program is rooted in the Program's strong interaction among CPC members and with other UACC Programs as well as its national and international collaborations.

项目摘要 /摘要：预防癌症控制计划（CPC） 亚利桑那大学癌症的癌症预防与控制计划（CPC）的科学目标 中心（UACC）将开发和实施高度互动，多学科的癌症预防和控制 研究，培训和推广将导致癌症发病率，发病率和 死亡。 CPC促进了高影响力，互动，多学科和翻译科学，以及 培训和宣传，为亚利桑那州南部的集水区提供服务。计划活动组织 在三个主要主题下：主题1）癌症流行病学；主题2）化学预防和生物标志物； 主题3）行为，社会心理和生活质量。 CPC具有与 这些主题：目标1）提高癌症预防知识并通过 流行病学科学的重点是生物学，环境和生活方式因素以及基因 与癌症风险，发病率和死亡率相关的环境相互作用；目标2）评估小说 化学预防化合物和生物标志物将通过关注 药物，营养和疫苗；目标3）测试行为，社会心理和生活质量 有针对性的干预措施，具有降低风险和改善癌症结局的高潜力。研究人员 通过癌症类型组织的跨学科团队来实现他们的努力，以整合剪裁 跨癌症预防和控制连续性的边缘研究活动，并解决特殊 集水区的种群和癌症负担。该计划有61名成员跨越21个学术 部门。该计划的领导者利用广泛的战略计划参与教师，学生和 共享资源总监，以确保该计划的成员可以及时访问资源 以及促进其研究目标所需的科学方法。截至2015年9月1日，CPC 计划获得了1700万美元的年度赠款，其中NCI的730万美元和640万美元的其他同行 审查资金。 CPC成员贡献了570个与癌症相关的手稿，其中37％是内部的 程序化和22％是程序间截面。实现CPC科学目标的能力 程序植根于该计划在CPC成员和其他UACC程序之间的牢固互动 以及其国家和国际合作。