Core C: Molecular Targets
Core C: Molecular Targets
批准号:
10475154
负责人:
H-H. Sherry CHOW
金额:
$29.58万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-10 至 2024-08-31
关键词:
Actinic keratosisAddressApoptoticArchitectureBiologicalBiological AssayBiological MarkersBiological Specimen BanksBiopsyBiostatistics CoreCellsClinical TrialsCollaborationsCollectionExposure toFormalinFreezingHematoxylin and Eosin Staining MethodHistopathologyHumanLaboratoriesLightMapsMeasurementMolecular TargetMusParaffin EmbeddingPathway interactionsPhasePhosphoproteinsPreventionProceduresProtein Microarray AssayProtein MicrochipsProteinsProtocols documentationReproducibilityResource DevelopmentResourcesSamplingServicesShippingSignal TransductionSignaling ProteinSkinSkin CarcinomaSlideSpecimenStainsStandardizationSunburnTLR4 geneThe SunThickTissue Microarrayclinical developmentcostcost effectivelaser capture microdissectionmethod developmentmolecular markermouse modelnovelprogramssample collectionskin damageskin squamous cell carcinomasun damagetissue processing
中文摘要
摘要
核心C(Chow,Petricoin)分子靶标
分子靶核是一个多功能的核心。核心提供收集、跟踪、存储和
生物样品分发点,是开展必要实验室工作的资源和服务
本申请中提出的分析。此外,分子靶标核心是
计划项目,因为它允许项目以一致的、可重复的和成本-
在分子标记鉴定方面的有效方式。核心将在一个重要的
对所有项目和其他核心的态度。此外,核心已经制定了详细的表格和标准作业程序,
是开发临床和小鼠方案以及样本管理的重要资源
对于一个不断增长的生物质谱库。与生物统计核心(核心B)、分子
目标核心将进行样本分析,并就转移和/或分析与每个项目进行互动
关于样本,以及对结果的管理和解释。核心提供
免疫组织化学方法的建立和分析。核心还提供反相蛋白质
微阵列(RPPA),一种多信号蛋白的多路定量测量,其中许多是
来自生物标本的磷蛋白。RPPA代表了一种新的定量测量方法
从一个样本中提取数百种蛋白质。
英文摘要
ABSTRACT
Core C (Chow, Petricoin) Molecular Targets
The Molecular Targets Core is a multi-functional core. The Core provides a collection, tracking, storage, and
distribution point for biological samples and is a resource and service for carrying out the necessary laboratory
analyses proposed in this application. Furthermore, the Molecular Targets Core is an essential component of
the Program Project in that it allows the Projects to address Specific Aims in a consistent, reproducible, and cost-
effective manner with regards to the identification of molecular markers. The Core will interact in a significant
manner with all Projects and the other cores. Additionally, the Core has put into place detailed forms and SOPs,
and is an essential resource for development of clinical and murine protocols as well as sample management
for a continually growing biospecimen repository. In collaboration with the Biostatistics Core (Core B), Molecular
Targets Core will carry-out sample analyses and interact with each Project on the transfer and/or analysis of
samples, as well as on the management and interpretation of the results. The Core provides
immunohistochemical method development and analysis. The Core also provides Reverse Phase Protein
Microarray (RPPA), a multiplexed quantitative measurement of multiple signaling proteins, many of which are
phosphoproteins, from biological specimens. RPPA represents a novel means of quantitative measurement of
hundreds of proteins from a single specimen.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Ultra-performance liquid chromatography - triple quadrupole mass spectrometry system
-
批准号:10629514
-
项目类别:
-
资助金额:$50.44万
-
财政年份:2023
-
负责人:H-H. Sherry CHOW
-
依托单位:
Core C: Molecular Targets
-
批准号:10252874
-
项目类别:
-
资助金额:$29.62万
-
财政年份:2019
-
负责人:H-H. Sherry CHOW
-
依托单位:
Core C: Molecular Targets
-
批准号:10686380
-
项目类别:
-
资助金额:$30.35万
-
财政年份:2019
-
负责人:H-H. Sherry CHOW
-
依托单位:
Core C: Molecular Targets
-
批准号:10015221
-
项目类别:
-
资助金额:$32.25万
-
财政年份:2019
-
负责人:H-H. Sherry CHOW
-
依托单位:
Program 4: Cancer Prevention and Control Program (CPC)
-
批准号:9315741
-
项目类别:
-
资助金额:$0.1万
-
财政年份:2017
-
负责人:H-H. Sherry CHOW
-
依托单位:
Metformin for Reduction of Obesity Associated Breast Cancer Risk
-
批准号:8906815
-
项目类别:
-
资助金额:$24.86万
-
财政年份:2013
-
负责人:H-H. Sherry CHOW
-
依托单位:
Metformin for Reduction of Obesity Associated Breast Cancer Risk
-
批准号:9108151
-
项目类别:
-
资助金额:$62.86万
-
财政年份:2013
-
负责人:H-H. Sherry CHOW
-
依托单位:
Metformin for Reduction of Obesity Associated Breast Cancer Risk
-
批准号:8576141
-
项目类别:
-
资助金额:$51.35万
-
财政年份:2013
-
负责人:H-H. Sherry CHOW
-
依托单位:
Metformin for Reduction of Obesity Associated Breast Cancer Risk
-
批准号:8733137
-
项目类别:
-
资助金额:$57.77万
-
财政年份:2013
-
负责人:H-H. Sherry CHOW
-
依托单位:
Metformin for Reduction of Obesity Associated Breast Cancer Risk
-
批准号:9284427
-
项目类别:
-
资助金额:$51.11万
-
财政年份:2013
-
负责人:H-H. Sherry CHOW
-
依托单位:
Clinical Study of Disposition and Biological Activity of d-Limonene
-
批准号:7895796
-
项目类别:
-
资助金额:$30.0万
-
财政年份:2009
-
负责人:H-H. Sherry CHOW
-
依托单位:
Analytical Core
-
批准号:7944518
-
项目类别:
-
资助金额:$14.24万
-
财政年份:2009
-
负责人:H-H. Sherry CHOW
-
依托单位:
Clinical Study of Disposition and Biological Activity of d-Limonene
-
批准号:7588687
-
项目类别:
-
资助金额:$23.25万
-
财政年份:2009
-
负责人:H-H. Sherry CHOW
-
依托单位:
DIRECT NOSE/BRAIN DRUG/PEPTIDE TRANSPORT
-
批准号:2740858
-
项目类别:
-
资助金额:$7.58万
-
财政年份:1999
-
负责人:H-H. Sherry CHOW
-
依托单位:
DIRECT NOSE/BRAIN DRUG/PEPTIDE TRANSPORT
-
批准号:6175706
-
项目类别:
-
资助金额:$7.51万
-
财政年份:1999
-
负责人:H-H. Sherry CHOW
-
依托单位:
Analytical Chemistry
-
批准号:10407088
-
项目类别:
-
资助金额:$18.8万
-
财政年份:1997
-
负责人:H-H. Sherry CHOW
-
依托单位:
Cancer Prevention and Control Program (CPCP)
-
批准号:10493907
-
项目类别:
-
资助金额:$6.87万
-
财政年份:1997
-
负责人:H-H. Sherry CHOW
-
依托单位:
Analytical Chemistry Shared Resource (ACSR)
-
批准号:10493915
-
项目类别:
-
资助金额:$12.84万
-
财政年份:1997
-
负责人:H-H. Sherry CHOW
-
依托单位:
Analytical Chemistry Shared Resource (ACSR)
-
批准号:10676912
-
项目类别:
-
资助金额:$13.23万
-
财政年份:1997
-
负责人:H-H. Sherry CHOW
-
依托单位:
Analytical Core
-
批准号:8540928
-
项目类别:
-
资助金额:$12.44万
-
财政年份:--
-
负责人:H-H. Sherry CHOW
-
依托单位:
海外基金