Analytical Core

9.1.1分析核心共享服务 分析核心共享服务(ACSS)的总体使命是为癌症中心研究人员提供执行分析化学分析以及药代动力学和药效学数据分析和解释的集中资源和专业知识。 具体地说，分析核心共享服务有以下目标： ？为开发和实施基于层析的生物分析方法提供支持，以量化生物标本中的癌症治疗和预防药物、营养素、致癌物和内源性生物化学物质； 在临床和临床前标本中癌症治疗和预防药物、营养素、致癌物和内源性生物化学物质的定量分析方面提供支持； ？为为生物分析分析收集的样品制定适当的样品处理和储存条件提供支持； 为设计药代动力学样本采集计划和药代动力学及药效学数据分析和解释提供支持。 这些服务可以评估药物/营养/致癌物质的暴露和处置情况。ACSS提供的服务还支持测量作为替代癌症风险生物标记物和药效终点的内源性化学物质。这些研究对亚利桑那州癌症中心目前正在进行的许多项目至关重要，特别是在以药物开发和癌症预防研究为重点的项目中。

9.1.1 ANALYTICAL CORE SHARED SERVICE The overall mission of the Analytical Core Shared Service (ACSS) is to provide Cancer Center investigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinetic and pharmacodynamic data analysis and interpretation. Specifically, the Analytical Core Shared Service has the following aims: ¿To provide support in developing and implementing chromatography-based bioanalytical assays for quantification of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biological specimens; ¿To provide support in quantitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and preclinical specimens; ¿To provide support in developing proper sample handling and storage conditions for specimens collected for bioanalytical assays; ¿To provide support in designing pharmacokinetic sample collection schedules and pharmacokinetic and pharmacodynamic data analysis and interpretation. These services allow for the assessment of drug/nutrient/carcinogen exposure and disposition. Services provided by ACSS also support measurement of endogenous chemicals as surrogate cancer-risk biomarkers and pharmacodynamic endpoints. These lines of research have been essential to many projects currently being carried out at the Arizona Cancer Center, especially in programs with an emphasis in drug development and cancer prevention research.