The ACT annual symposium: a living, learning, national collaboratory to advance Alzheimer's disease and brain aging research

项目概要/摘要 阿尔茨海默病（AD）的诊断和死亡正在上升-540万人目前生活在 仅2016年就将有70万人死亡。没有可靠的方法来预防，早期发现， 疗方自2011年以来，成人思想变化（ACT）研究招募了5,000多名65岁以上的成年人。 1994年，每两年随访一次，以诊断新的痴呆症和AD。ACT数据有助于生活， 学习合作实验室，作为AD和大脑的宝贵科学资源，为研究社区服务 老化研究在过去的四年里，我们每年都举办ACT研讨会，以突出新的ACT 资源，创新的研究成果和跨学科的合作。我们用最少的 来自ACT家长U 01的支持。这次会议赠款将为我们不断增长的研讨会提供新的支持， 未来三年我们的会议补助金的具体目标是：1）促进适当的科学 ACT数据的使用和理解; 2）促进跨科学学科，机构的合作， 提供机会，就正在进行和计划进行的工作，包括正在进行的分析提供反馈意见 和新的资助理念，特别是对初级研究人员。这一新的资金来源将为我们提供支持， 把我们的会议地点搬到一个更大、技术更先进的设施。它还将提供旅行 研究人员从外地旅行的津贴，使我们可以扩大我们的接触到新的外部 investigators.我们预计未来的会议（2017年夏末，2018年和2019年在西雅图， 华盛顿）将涵盖老龄化和痴呆症研究的热门话题，如恢复力，成像，痴呆症 亚型，分子表型和创伤性脑损伤-ACT正在重要的主题 捐款.从长远来看，扩大我们的ACT研讨会将增加ACT生活实验室的使用， 推进AD和大脑老化研究。

Project Summary/Abstract Alzheimer's disease (AD) diagnoses and deaths are on the rise – 5.4 million are currently living with the disease and 700,000 will die in 2016 alone. There is no sure-fire method for prevention, early detection, or cure. The Adult Changes in Thought (ACT) study has recruited over 5,000 adults over the age of 65 since 1994, and follows them every 2 years for new dementia and AD diagnoses. ACT data contribute to a living, learning co-laboratory, which serves the research community as a valuable scientific resource for AD and brain aging research. For the past four years, we have held an annual ACT Symposium to highlight new ACT resources, innovative research findings, and cross-disciplinary collaborations. We have done this with minimal support from the ACT parent U01. This conference grant will provide new support for our growing symposia for the next three years. The specific objectives of our conference grant are to: 1) promote appropriate scientific use and understanding of ACT data; 2) promote collaborations across scientific disciplines, institutions, and studies; and 3) provide opportunities for feedback on ongoing and planned work including analyses in progress and new grant ideas particularly for junior investigators. This new funding source will provide support for us to move our conference location to a larger, more technologically advanced facility. It will also provide travel stipends for investigators traveling from out of town so that we may extend our reach to new external investigators. We anticipate that future conferences (in late summer of 2017, 2018, and 2019 in Seattle, Washington) will cover hot topics in aging and dementia research such as resilience, imaging, dementia subtypes, molecular phenotypes, and traumatic brain injury – topic to which ACT is making significant contributions. Long term, expanding our ACT symposia will increase use of the ACT living laboratory, and advance AD and brain aging research.