Annual Adult Changes in Thought (ACT) symposium on aging, dementia, and Alzheimer's disease

项目摘要/摘要 目前有近600万美国成年人患有阿尔茨海默病(AD)，其中70万人将 仅在2019年就去世了。预防、及早发现或治愈没有简单的解决方案。自1994年以来，《成年人》 思维变化(ACT)研究已经收集了超过5500人的观察、临床和实验室数据 并随着时间的推移跟踪他们是否有痴呆症和阿尔茨海默病的迹象。动作数据 建立一个活生生的、学习的实验室，作为研究界的科学资源。为 在过去的七年里，我们每年举办一次ACT研讨会，展示ACT的新资源，突出 创新研究成果，分享新的拨款想法，促进跨学科合作。每一年 我们在研讨会后的评估中获得了更高的评级，去年98%的与会者 表示将向其他人推荐研讨会，并100%表示将参加未来的研讨会 ACT研讨会。然而，如果没有会议赠款，我们没有能力举办未来的研讨会。 资金问题。这笔会议赠款将为在未来五年继续和扩大ACT专题讨论会提供支持 好几年了。我们会议赠款的具体目标是：1)促进科学使用和理解 ACT数据；2)促进跨科学学科、机构和研究的合作；以及3)提供 对正在进行的和计划中的工作进行反馈的机会，如正在进行的分析或新的赠款想法， 尤其是对初级调查员来说。这笔资金将使我们能够在一个大型的、可访问的 会场配有先进的视听设备。它还将为初级研究人员提供旅行津贴， 来自少数族裔群体的研究人员，以及从外地赶来的研究人员，所以我们 可能会将我们的触角伸向新的外部调查人员。未来的会议将涵盖老龄化和 痴呆症研究，如恢复力、影像、痴呆亚型、分子表型、创伤性脑 受伤，以及其他。从长远来看，继续和扩大ACT研讨会将增加ACT生活的使用 实验室，并为顶尖研究人员提供一个创造性的、欢迎的空间来交流创新研究 并加速AD和脑老化的研究。

Project Summary/Abstract Nearly 6 million U.S. adults are currently living with Alzheimer’s disease (AD), and 700,000 of these people will die in 2019 alone. There is no simple solution for prevention, early detection, or cure. Since 1994, the Adult Changes in Thought (ACT) study has collected observational, clinical, and laboratory data on more than 5,500 older adults and is following them over time for signs of dementia and Alzheimer’s disease. ACT data contribute to a living, learning laboratory, which serves as a scientific resource for the research community. For the past seven years, we have held an annual ACT symposium to showcase new ACT resources, highlight innovative research findings, share new grant ideas, and promote cross-disciplinary collaborations. Every year we have received higher ratings on our post-symposium evaluations, with 98% of last year’s attendees indicating they would recommend the symposium to others and 100% indicating they would attend a future ACT symposium. However, we do not have the capacity to hold future symposia without conference grant funding. This conference grant will provide support to continue and grow the ACT symposia over the next five years. The specific objectives of our conference grant are to: 1) promote scientific use and understanding of ACT data; 2) promote collaborations across scientific disciplines, institutions, and studies; and 3) provide opportunities for feedback on ongoing and planned work such as analyses-in-progress or new grant ideas, particularly for junior investigators. This funding will allow us to host the symposium in a large, accessible venue with advanced audiovisual equipment. It also will provide travel stipends for junior researchers, investigators from underrepresented minority groups, and researchers traveling from out of town so that we may extend our reach to new external investigators. Future conferences will cover critical topics in aging and dementia research such as resilience, imaging, dementia subtypes, molecular phenotypes, traumatic brain injury, and others. Long term, continuing and expanding the ACT symposia will increase use of the ACT living laboratory and provide a creative, welcoming space for top investigators to exchange innovative research ideas and accelerate AD and brain aging research.