Neural substrates of attention and social cognition impairment in schizophrenia

精神分裂症注意力和社会认知障碍的神经基础

• 批准号: 9331745
• 负责人: Gaurav H Patel
• 金额: $ 19.91万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-12 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9331745
• 关键词: Area; Attention; Attitude; Behavior; Behavioral; Biological Markers; Brain; Brain region; Chronic; Communication; Complex; Development; Doctor of Philosophy; Dorsal; Emotional; Emotions; Empathy; Environment; Face; Face Processing; Facial Expression; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Homelessness; Human; Image; Impaired cognition; Impairment; Imprisonment; Individual; Interview; Knowledge; Lead; Maps; Measures; Mediating; Mental disorders; Mentors; Methods; Mind; Monitor; Monkeys; Morbidity - disease rate; Motion; Occupations; Outcome; Patients; Pattern; Perception; Performance; Physiology; Play; Population; Process; Program Development; Research; Research Domain Criteria; Research Personnel; Rest; Risk; Role; Scanning; Schizophrenia; Social Functioning; Social Perception; Specific qualifier value; Stimulus; Structure of superior temporal sulcus; Symptoms; Techniques; Testing; Training; Translating; Unemployment; Visual; Visual Perception; Visual impairment; Work; base; behavior measurement; career; career development; connectome; design; disability; experimental study; frontal eye fields; imaging approach; intraparietal sulcus; mental state; movie; neuroimaging; neuromechanism; neuropsychiatric disorder; neuropsychiatry; novel; novel strategies; patient oriented research; programs; relating to nervous system; retinotopic; skills; social; social cognition; social communication; social communication impairment; social situation; study population; theories

Schizophrenia (Sz) is associated with deficits in face emotion recognition (FER) that contribute directly to overall impairments in social communication and global outcome. These deficits may be related to dysfunction of face processing regions of the brain such as posterior superior temporal sulcus (pSTS). This region is also known to interact closely with the ventral attention network (VAN), which involves temporoparietal junction (TPJ) and the dorsal attention network (DAN), which involves intraparietal sulcus (IPS) and frontal eye fields (FEF). This project investigates the role of TPJ-pSTS dysfunction in mediating facial social communication impairments in Sz. The project builds directly from the candidate's prior PhD studies investigating TPJ function in humans and monkeys, as well as his more recent studies during fellowship investigating pSTS dysfunction during naturalistic scene processing in Sz. The application proposes a 4-year career development program which will permit the candidate's development into an independent investigator in patient-oriented research focusing on social communication impairments in neuropsychiatric disorders. During the project, he will work directly with mentors who are experts in the areas of perception (Drs. Javitt and Ferrera), attention (Drs. Gottlieb and Curtis), and social cognition (Dr. Ochsner), and will pursue integrated didactics and research focusing on the relationship between impairments in social communication and impairments in perception, attention and social cognition in Sz. On the neural level, the hypothesis is that these deficits will represent impaired interactions between TPJ-pSTS and other brain regions including visual perceptual regions (e.g. V1, MT), attention networks (VAN, DAN), and theory of mind networks (e.g. MFG, vmPFC). A novel feature of the project is the use of naturalistic imaging (collaborators: Drs. Hasson and Leopold) in which activation of and functional connectivity between brain regions is monitored continuously while subjects view ecologically valid stimuli (e.g. social vignettes). Human Connectome Project acquisition and processing approaches are implemented and will be used for all studies. Overall, this program will prepare me for an independent career using advanced fMRI approaches, including task-based, resting state and naturalistic fMRI, for the study of the neural basis of social communication impairments across neuropsychiatric disorders. Relevance: Impaired social communication in schizophrenia is associated with long-term disability. The present study investigates the neural bases of these deficits, and prepares the candidate for a career in studying social communication deficits in psychiatric disorders.

精神分裂症(Sz)与面部情绪识别(FER)缺陷有关，FER直接导致 社会沟通和全球结果方面的总体障碍。这些缺陷可能与功能障碍有关。 大脑的面部加工区，如后上颞沟(PSTS)。这一地区也是 已知与涉及颞顶交界处的腹侧注意网络(VAN)密切相互作用 (TPJ)和背侧注意网络(DAN)，它涉及顶内沟(IPS)和前额眼区 (FEF)。本项目调查了TPJ-pSTS功能障碍在调节面部社交交流中的作用 Sz中的减损。该项目直接建立在候选人先前研究TPJ功能的博士研究基础上 在人类和猴子身上，以及他在团契期间调查pSTS功能障碍的最新研究 在深圳的自然场景处理过程中。申请书提出了一个为期4年的职业发展计划。 这将允许候选人发展成为以患者为导向的研究的独立调查者 关注神经精神障碍中的社交障碍。在项目期间，他将工作 直接与知觉领域的专家导师(贾维特博士和费雷拉博士)、注意力(博士。 Gottlieb和Curtis)和社会认知(Ochsner博士)，并将从事综合教学学和研究 关注社交障碍和知觉障碍之间的关系， 关注度与社会认知。在神经层面上，假设这些缺陷将代表 TPJ-PSTS与包括视觉感知区域在内的其他脑区域之间的相互作用受损(例如，V1， MT)、注意网络(van、Dan)和心理理论网络(例如MFG、vmPFC)。的一个新特点。 项目是使用自然主义成像(合作者：哈森博士和利奥波德博士)，其中激活和 在受试者观察生态有效性的同时，持续监测大脑区域之间的功能连接 刺激(例如社交小插曲)。获取和处理Human Connectome项目的方法有 实施并将用于所有研究。总的来说，这个项目将为我独立的职业生涯做好准备 使用先进的功能磁共振成像方法，包括基于任务的、休息状态的和自然主义的功能磁共振成像方法，用于研究 神经精神障碍的社会沟通障碍的神经基础。 相关性：精神分裂症患者社交能力受损与长期残疾有关。这个 本研究调查了这些缺陷的神经基础，并为候选人在以下领域的职业生涯做准备 研究精神障碍中的社交缺陷。