Neural substrates of deficits in naturalistic social cognition in schizophrenia

精神分裂症自然社会认知缺陷的神经基础

• 批准号: 10626092
• 负责人: Gaurav H Patel
• 金额: $ 66.97万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626092
• 关键词: Address; Affect; Applications Grants; Area; Attention; Behavior; Behavioral; Brain; Brain imaging; Brain region; Chronic; Clinical; Cognitive; Communication; Compensation; Complex; Cues; Data; Detection; Diagnostic tests; Disease; Dorsal; Emotions; Eye Movements; Face; Facial Expression; Facial Expression Perception; Failure; Feeling; Frequencies; Future; Generations; Homelessness; Human; Impaired cognition; Impairment; Imprisonment; Individual; Interview; K-Series Research Career Programs; Lead; Location; Maps; Measures; Mediating; Mental disorders; Mind; Motion; National Institute of Mental Health; Occupations; Participant; Patients; Pattern; Peripheral; Play; Population; Property; Psychophysics; Rehabilitation therapy; Research; Retina; Risk; Role; Saccades; Scanning; Schizophrenia; Social Functioning; Social Perception; Stimulus; Structure of superior temporal sulcus; Symptoms; System; Techniques; Testing; Thinking; Time; Unemployment; Vision; Visual; Visual Fields; Width; Work; base; cognitive rehabilitation; design; disability; experimental study; fovea centralis; innovation; mentalization; movie; neural; neuromechanism; neuroregulation; novel; novel diagnostics; receptive field; repaired; retinotopic; showing emotion; social; social cognition; social situation; theories; visual information; visual map; visual processing

Project Summary: Psychiatric disorders such as schizophrenia are often marked by poor social cognition, but little is known about the neural mechanisms underlying these deficits. Visual scanning of social scenes for relevant social cues is a key domain of social cognition, and is necessary to detect and use social cues to understand the thoughts and feelings of others in the social scene (mentalization). The targeting of those eye- movements are often driven by facial expressions of emotion, which are salient, or stand out from other visual features, and are behaviorally relevant, or known to contain information useful for understanding the social situation. Recent work from my lab has found abnormalities in the visual scanning of naturalistic social scenes (movies of staged social scenes) in schizophrenia, which resulted in decreased detection of facial expressions and affected understanding of those scenes. I have also found gross functional deficits in the temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS), a region of the brain that contains brain areas related to the perception of facial expressions of emotion, guiding of eye-movements, and mentalization. This grant application aims to build on these findings by investigating the functional integrity of the cortical areas involved in the transformation of the visual information into plans for saccadic eye-movements in individuals with schizophrenia versus demographically matched healthy controls. I am proposing to perform a combination of free-viewing naturalistic and rigorously controlled psychophysical experiments to study these areas. We will use techniques that my lab has adapted from Dr. David Leopold and others to separately assess the integrity of the TPJ-pSTS in the visual processing, communications with other areas, and generation of saccades during free-viewing of movies. We will also examine the organization and functioning of the dorsal attention areas that control eye-movements. These frontoparietal areas are retinotopically mapped, meaning that they contain a 1:1 map of the visual field centered on the fovea of the retina. With Dr. Clayton Curtis, I will map these areas in each individual, and then examine whether the activity within these maps mirrors the salient and behaviorally relevant visual features in the movies viewed by the participants. Lastly, we will examine whether failures in visual scanning in SzP are related to deficits in the functioning of the TPJ-pSTS, dorsal attention areas, or both. The proposed experiments address several unmet needs outlined in the NIMH Strategic Objectives. The results of the proposed experiments will provide (as far as we know) the first full circuit-level map of a complex behavior that has direct psychiatric relevance. The results will also shed light on possible microcircuit deficits that may lead to retinotopic map abnormalities. With this information, I will then be able to design low- burden tests of social functioning easily deployed in clinical settings, and also start investigating rehabilitation or neuromodulation treatments to repair or compensate for these social cognition deficits in schizophrenia.

项目概述：精神分裂症等精神疾病通常以社会认知能力差为特征，但是

项目成果

Brain connectivity at rest predicts individual differences in normative activity during movie watching.

• DOI: 10.1016/j.neuroimage.2022.119100
• 发表时间: 2022-06
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Gruskin, David C.;Patel, Gaurav H.
• 通讯作者: Patel, Gaurav H.

Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia.

• DOI: 10.3389/fnbeh.2021.787383
• 发表时间: 2021
• 期刊: Frontiers in behavioral neuroscience
• 影响因子: 3
• 作者: Martínez A;Tobe RH;Gaspar PA;Malinsky D;Dias EC;Sehatpour P;Lakatos P;Patel GH;Bermudez DH;Silipo G;Javitt DC
• 通讯作者: Javitt DC