Neural substrates of deficits in naturalistic social cognition in schizophrenia

精神分裂症自然社会认知缺陷的神经基础

• 批准号: 10626092
• 负责人: Gaurav H Patel
• 金额: $ 66.97万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626092
• 关键词: Address; Affect; Applications Grants; Area; Attention; Behavior; Behavioral; Brain; Brain imaging; Brain region; Chronic; Clinical; Cognitive; Communication; Compensation; Complex; Cues; Data; Detection; Diagnostic tests; Disease; Dorsal; Emotions; Eye Movements; Face; Facial Expression; Facial Expression Perception; Failure; Feeling; Frequencies; Future; Generations; Homelessness; Human; Impaired cognition; Impairment; Imprisonment; Individual; Interview; K-Series Research Career Programs; Lead; Location; Maps; Measures; Mediating; Mental disorders; Mind; Motion; National Institute of Mental Health; Occupations; Participant; Patients; Pattern; Peripheral; Play; Population; Property; Psychophysics; Rehabilitation therapy; Research; Retina; Risk; Role; Saccades; Scanning; Schizophrenia; Social Functioning; Social Perception; Stimulus; Structure of superior temporal sulcus; Symptoms; System; Techniques; Testing; Thinking; Time; Unemployment; Vision; Visual; Visual Fields; Width; Work; base; cognitive rehabilitation; design; disability; experimental study; fovea centralis; innovation; mentalization; movie; neural; neuromechanism; neuroregulation; novel; novel diagnostics; receptive field; repaired; retinotopic; showing emotion; social; social cognition; social situation; theories; visual information; visual map; visual processing

Project Summary: Psychiatric disorders such as schizophrenia are often marked by poor social cognition, but little is known about the neural mechanisms underlying these deficits. Visual scanning of social scenes for relevant social cues is a key domain of social cognition, and is necessary to detect and use social cues to understand the thoughts and feelings of others in the social scene (mentalization). The targeting of those eye- movements are often driven by facial expressions of emotion, which are salient, or stand out from other visual features, and are behaviorally relevant, or known to contain information useful for understanding the social situation. Recent work from my lab has found abnormalities in the visual scanning of naturalistic social scenes (movies of staged social scenes) in schizophrenia, which resulted in decreased detection of facial expressions and affected understanding of those scenes. I have also found gross functional deficits in the temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS), a region of the brain that contains brain areas related to the perception of facial expressions of emotion, guiding of eye-movements, and mentalization. This grant application aims to build on these findings by investigating the functional integrity of the cortical areas involved in the transformation of the visual information into plans for saccadic eye-movements in individuals with schizophrenia versus demographically matched healthy controls. I am proposing to perform a combination of free-viewing naturalistic and rigorously controlled psychophysical experiments to study these areas. We will use techniques that my lab has adapted from Dr. David Leopold and others to separately assess the integrity of the TPJ-pSTS in the visual processing, communications with other areas, and generation of saccades during free-viewing of movies. We will also examine the organization and functioning of the dorsal attention areas that control eye-movements. These frontoparietal areas are retinotopically mapped, meaning that they contain a 1:1 map of the visual field centered on the fovea of the retina. With Dr. Clayton Curtis, I will map these areas in each individual, and then examine whether the activity within these maps mirrors the salient and behaviorally relevant visual features in the movies viewed by the participants. Lastly, we will examine whether failures in visual scanning in SzP are related to deficits in the functioning of the TPJ-pSTS, dorsal attention areas, or both. The proposed experiments address several unmet needs outlined in the NIMH Strategic Objectives. The results of the proposed experiments will provide (as far as we know) the first full circuit-level map of a complex behavior that has direct psychiatric relevance. The results will also shed light on possible microcircuit deficits that may lead to retinotopic map abnormalities. With this information, I will then be able to design low- burden tests of social functioning easily deployed in clinical settings, and also start investigating rehabilitation or neuromodulation treatments to repair or compensate for these social cognition deficits in schizophrenia.

项目概述：精神分裂症等精神疾病通常以社会认知差为特征，但 对这些缺陷背后的神经机制知之甚少。社交场景的视觉扫描， 相关的社会线索是社会认知的一个关键领域，并且是检测和使用社会线索以 理解社交场景中他人的想法和感受（心理化）。把那些眼睛作为目标- 动作通常由情绪的面部表情驱动，这些表情是突出的，或者从其他视觉中脱颖而出。 特征，并且是行为相关的，或者已知包含对理解社交网络有用的信息。 形势我的实验室最近的工作发现，在对自然主义社会场景的视觉扫描中， （上演社交场景的电影）在精神分裂症中，这导致面部表情的检测减少 影响了对这些场景的理解。我还发现颞顶区有严重的功能缺陷 交界处/后上级颞沟（TPJ-pSTS），一个包含大脑相关区域的大脑区域 对情绪的面部表情的感知，眼动的引导和心理化。这笔赠款 应用程序旨在通过调查相关皮质区域的功能完整性来建立这些发现 在将视觉信息转化为具有以下特征的个体的扫视眼球运动的计划中， 精神分裂症与人口统计学匹配的健康对照组。 我建议表演一种自由观看的自然主义和严格控制的结合 心理物理实验来研究这些领域。我们将使用我的实验室从Dr. 大卫利奥波德和其他人单独评估TPJ-pSTS在视觉处理中的完整性， 与其他区域的通信，以及在自由观看电影期间产生扫视。我们还将 检查控制眼球运动的背侧注意区域的组织和功能。这些 额顶叶区域是视网膜定位的，这意味着它们包含1：1的视野图 以视网膜中央凹为中心。和克莱顿柯蒂斯博士一起，我将绘制每个人的这些区域，然后 检查这些地图中的活动是否反映了 参与者观看的电影。最后，我们将检查SzP中的视觉扫描失败是否 与TPJ-pSTS、背侧注意区域或两者的功能缺陷有关。 拟议的实验解决了NIMH战略目标中概述的几个未满足的需求。 拟议实验的结果将提供（据我们所知）第一个完整的电路级地图， 有直接精神关联的复杂行为结果也将揭示可能的微电路 可能导致视网膜定位图异常的缺陷。有了这些信息，我就能设计出低- 社会功能的负担测试很容易在临床环境中部署，并开始研究康复 或神经调节治疗来修复或补偿精神分裂症患者的这些社会认知缺陷。

项目成果

Brain connectivity at rest predicts individual differences in normative activity during movie watching.

• DOI: 10.1016/j.neuroimage.2022.119100
• 发表时间: 2022-06
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Gruskin, David C.;Patel, Gaurav H.
• 通讯作者: Patel, Gaurav H.

Disease-Specific Contribution of Pulvinar Dysfunction to Impaired Emotion Recognition in Schizophrenia.

• DOI: 10.3389/fnbeh.2021.787383
• 发表时间: 2021
• 期刊: Frontiers in behavioral neuroscience
• 影响因子: 3
• 作者: Martínez A;Tobe RH;Gaspar PA;Malinsky D;Dias EC;Sehatpour P;Lakatos P;Patel GH;Bermudez DH;Silipo G;Javitt DC
• 通讯作者: Javitt DC