Neural substrates of attention and social cognition impairment in schizophrenia

精神分裂症注意力和社会认知障碍的神经基础

• 批准号: 9531441
• 负责人: Gaurav H Patel
• 金额: $ 19.83万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-12 至 2020-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9531441
• 关键词: Area; Attention; Attitude; Behavior; Behavioral; Biological Markers; Brain; Brain region; Chronic; Communication; Complex; Development; Doctor of Philosophy; Dorsal; Emotional; Emotions; Empathy; Environment; Face; Face Processing; Facial Expression; Fellowship; Functional Magnetic Resonance Imaging; Functional disorder; Homelessness; Human; Image; Impaired cognition; Impairment; Imprisonment; Individual; Interview; Knowledge; Lead; Maps; Measures; Mediating; Mental disorders; Mentors; Methods; Mind; Monitor; Monkeys; Morbidity - disease rate; Motion; Occupations; Outcome; Patients; Pattern; Perception; Performance; Physiology; Play; Population; Process; Program Development; Research; Research Domain Criteria; Research Personnel; Rest; Risk; Role; Scanning; Schizophrenia; Social Functioning; Social Perception; Specific qualifier value; Stimulus; Structure of superior temporal sulcus; Symptoms; Techniques; Testing; Training; Translating; Unemployment; Visual; Visual Perception; Visual impairment; Work; base; behavior measurement; career; career development; connectome; design; disability; experimental study; frontal eye fields; imaging approach; intraparietal sulcus; mental state; movie; neuroimaging; neuromechanism; neuropsychiatric disorder; neuropsychiatry; novel; novel strategies; patient oriented research; programs; relating to nervous system; retinotopic; skills; social; social cognition; social communication; social communication impairment; social situation; study population; theories

Schizophrenia (Sz) is associated with deficits in face emotion recognition (FER) that contribute directly to overall impairments in social communication and global outcome. These deficits may be related to dysfunction of face processing regions of the brain such as posterior superior temporal sulcus (pSTS). This region is also known to interact closely with the ventral attention network (VAN), which involves temporoparietal junction (TPJ) and the dorsal attention network (DAN), which involves intraparietal sulcus (IPS) and frontal eye fields (FEF). This project investigates the role of TPJ-pSTS dysfunction in mediating facial social communication impairments in Sz. The project builds directly from the candidate's prior PhD studies investigating TPJ function in humans and monkeys, as well as his more recent studies during fellowship investigating pSTS dysfunction during naturalistic scene processing in Sz. The application proposes a 4-year career development program which will permit the candidate's development into an independent investigator in patient-oriented research focusing on social communication impairments in neuropsychiatric disorders. During the project, he will work directly with mentors who are experts in the areas of perception (Drs. Javitt and Ferrera), attention (Drs. Gottlieb and Curtis), and social cognition (Dr. Ochsner), and will pursue integrated didactics and research focusing on the relationship between impairments in social communication and impairments in perception, attention and social cognition in Sz. On the neural level, the hypothesis is that these deficits will represent impaired interactions between TPJ-pSTS and other brain regions including visual perceptual regions (e.g. V1, MT), attention networks (VAN, DAN), and theory of mind networks (e.g. MFG, vmPFC). A novel feature of the project is the use of naturalistic imaging (collaborators: Drs. Hasson and Leopold) in which activation of and functional connectivity between brain regions is monitored continuously while subjects view ecologically valid stimuli (e.g. social vignettes). Human Connectome Project acquisition and processing approaches are implemented and will be used for all studies. Overall, this program will prepare me for an independent career using advanced fMRI approaches, including task-based, resting state and naturalistic fMRI, for the study of the neural basis of social communication impairments across neuropsychiatric disorders. Relevance: Impaired social communication in schizophrenia is associated with long-term disability. The present study investigates the neural bases of these deficits, and prepares the candidate for a career in studying social communication deficits in psychiatric disorders.

精神分裂症（Sz）与面部情绪识别（FER）的缺陷有关，这直接导致 社会沟通和全球结果的整体损害。这些缺陷可能与功能障碍有关 大脑的面部处理区域，例如后颞上沟（pSTS）。上级颞沟。该地区也是 已知与腹侧注意网络（货车）密切相关，该网络涉及颞顶连接 (TPJ)背侧注意网络（DAN），涉及顶内沟（IPS）和额眼区 （FEF）。本研究旨在探讨TPJ-pSTS功能障碍在调节面部社会交流中的作用 在Sz的缺陷。该项目直接建立在候选人以前的博士研究调查TPJ功能 以及他最近在研究pSTS功能障碍期间的研究 在自然主义场景处理中，申请书提出4年职业发展计划 这将使候选人的发展成为一个独立的调查员在以病人为导向的研究 专注于神经精神疾病中的社会沟通障碍。在项目期间，他将 直接与导师谁是在感知领域的专家（贾维特博士和费雷拉），注意力（博士。 戈特利布和柯蒂斯），社会认知（博士奥克斯纳），并将追求综合教学和研究 专注于社会沟通障碍和感知障碍之间的关系， 注意力和社会认知。在神经水平上，假设这些缺陷将代表 TPJ-pSTS和包括视觉感知区域（例如V1， MT）、注意力网络（货车、DAN）和心理理论网络（例如MFG、vmPFC）。的一个新颖特征 该项目是使用自然成像（合作者：哈森和利奥波德博士），其中激活和 大脑区域之间的功能连接被持续监测，同时受试者认为生态有效 刺激（例如社交小插曲）。人类连接组项目的获取和处理方法是 已实施并将用于所有研究。总的来说，这个项目将为我的独立职业生涯做好准备。 使用先进的功能磁共振成像方法，包括基于任务的，静息状态和自然的功能磁共振成像，研究 社会沟通障碍的神经基础。 相关性：精神分裂症患者的社会沟通障碍与长期残疾有关。的 本研究调查了这些缺陷的神经基础，并为候选人的职业生涯做好准备。 研究精神疾病中的社交障碍