Optical Coherence Elastography of the Cornea

角膜光学相干弹性成像

基本信息

批准号：
9263963
负责人：
Salavat R Aglyamov
金额：
$ 40.33万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2020-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9263963
关键词：
Agreement Air Air Pressure Animals Anisotropy Anterior Biomechanics Cataract Extraction Characteristics Clinic Clinical Clinical Research Clinical Treatment Cornea Corneal Diseases Corneal Injury Detection Development Diagnostic Diagnostic tests Discipline Disease Elasticity Eye Funding Future Glaucoma Heterogeneity Human Iatrogenesis Image In Vitro Intervention Keratoconus Knowledge Light Measurement Measures Mechanics Methods Modality Modeling Modification Myopia Nature Operative Surgical Procedures Optical Coherence Tomography Optics Oryctolagus cuniculus Pathologic Patients Phase Physiologic Intraocular Pressure Physiological Property Reporting Research Resolution Riboflavin Rose Bengal Routine Diagnostic Tests Scanning Source Speed Surface System Talents Techniques Technology Therapeutic Tissues Transplanted tissue Tunic Work Wound Healing attenuation base biomechanical model clinical diagnostics clinically relevant crosslink elastography imaging system improved improved outcome in vivo instrument instrumentation mechanical properties multidisciplinary new technology novel novel strategies personalized medicine physical property pressure prototype public health relevance reconstruction response success therapy outcome tissue phantom tool ultra high resolution

项目摘要

DESCRIPTION (provided by applicant): Optical Coherence Elastography of the Cornea The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our long-term objectives are to use the coordinated talents of this research team to produce novel elasticity imaging instrumentation/methods that can extend our current understanding of the basic principles of tissue biomechanics and apply this knowledge to clinically relevant problems in ocular disease.

DESCRIPTION (provided by application): Optical Coherence Elasticism of the Cornea The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastation disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery.这些生物力学组织特征不仅影响了我们对诊断测试的临床解释，例如眼内的测量压力，但已被作为青光眼发展的重要因素。当前，没有可靠的可靠方法来测量体内角膜弹性。在这里，我们将开发新的方法来评估角膜弹性特性，这些方法可能可能用于常规的临床诊断和治疗。该方法将利用高度局部的气压刺激和超敏感的检测，并分析具有光学相干断层扫描的角膜后和前表面的压力波传播，以重建角膜的体积生物力学特性。我们的长期目标是利用该研究团队的协调才能来生成新颖的弹性成像仪器/方法，以扩展我们当前对组织生物力学基本原理的理解，并将这些知识应用于眼部疾病的临床相关问题。