Optical Coherence Elastography of the Cornea

角膜光学相干弹性成像

• 批准号: 9263963
• 负责人: Salavat R Aglyamov
• 金额: $ 40.33万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9263963
• 关键词: Agreement; Air; Air Pressure; Animals; Anisotropy; Anterior; Biomechanics; Cataract Extraction; Characteristics; Clinic; Clinical; Clinical Research; Clinical Treatment; Cornea; Corneal Diseases; Corneal Injury; Detection; Development; Diagnostic; Diagnostic tests; Discipline; Disease; Elasticity; Eye; Funding; Future; Glaucoma; Heterogeneity; Human; Iatrogenesis; Image; In Vitro; Intervention; Keratoconus; Knowledge; Light; Measurement; Measures; Mechanics; Methods; Modality; Modeling; Modification; Myopia; Nature; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Pathologic; Patients; Phase; Physiologic Intraocular Pressure; Physiological; Property; Reporting; Research; Resolution; Riboflavin; Rose Bengal; Routine Diagnostic Tests; Scanning; Source; Speed; Surface; System; Talents; Techniques; Technology; Therapeutic; Tissues; Transplanted tissue; Tunic; Work; Wound Healing; attenuation; base; biomechanical model; clinical diagnostics; clinically relevant; crosslink; elastography; imaging system; improved; improved outcome; in vivo; instrument; instrumentation; mechanical properties; multidisciplinary; new technology; novel; novel strategies; personalized medicine; physical property; pressure; prototype; public health relevance; reconstruction; response; success; therapy outcome; tissue phantom; tool; ultra high resolution

 DESCRIPTION (provided by applicant): Optical Coherence Elastography of the Cornea The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our long-term objectives are to use the coordinated talents of this research team to produce novel elasticity imaging instrumentation/methods that can extend our current understanding of the basic principles of tissue biomechanics and apply this knowledge to clinically relevant problems in ocular disease.

 描述（由申请人提供）：角膜的光学相干弹性成像眼睛外膜的基本物理性质决定了眼球地球仪的结构特征，并且在几种破坏性疾病状态下可能发生改变，包括近视眼的轴向延长、圆锥角膜的病理性变形和角膜屈光手术后的医源性角膜扩张。这些生物力学组织特征不仅影响我们对诊断测试的临床解释，例如眼内测量， 压力，但已被牵连的重要因素在青光眼的发展。目前，还没有一种可靠的方法来测量活体角膜的弹性。在这里，我们将开发新的方法来评估角膜弹性特性，可能会用于常规的临床诊断和治疗。该方法将利用高度局部化的气压刺激和光学相干断层扫描对角膜后表面和前表面上的压力波传播的超灵敏检测和分析来重建角膜的体积生物力学特性。我们的长期目标是利用这个研究团队的协调人才，生产新的弹性成像仪器/方法，可以扩展我们目前对组织生物力学基本原理的理解，并将这些知识应用于眼科疾病的临床相关问题。