Optical Coherence Elastography of the Cornea

项目总结 眼睛外衣的基本物理属性决定了眼睛的结构特征 眼球并可能在几种破坏性疾病状态下发生改变，包括近视眼的轴向延长， 角膜屈光手术后圆锥角膜的病理变形和医源性角膜扩张。这些 生物力学组织特征不仅影响我们对诊断测试的临床解释，例如 测量眼压，但一直被认为是发展的重要因素 青光眼。目前，尚无可靠的方法对角膜进行定量测量 体内弹性。在这里，我们将开发一种新的方法来评估角膜弹性特性，它可以 有可能用于常规的临床诊断和治疗。这种方法将充分利用 局部气压刺激与压力波传播的超灵敏检测与分析 线场光学相干层析重建角膜前后表面的研究 角膜的体积生物力学特性。我们以前的工作在以下方面取得了根本性进展 通过一种新的方法理解角膜生物力学，并在其他领域具有潜在的影响应用 学科(例如，白内障手术、LAISK、角膜交联术和个性化组织移植 处理)。拟议的研究将加速这项技术转化为临床，影响我们的选择 和角膜手术治疗的应用，将有助于我们理解角膜手术的结构性后果 角膜疾病和伤口愈合： 目的1.研制一种适用于超高速三维临床成像的线场OCE(LF-OCE)系统。 目的2.用兔进行体内实验。 目的3.人类的初步临床研究。 目的4.改进深度相关非线性的数值(有限元)和人工智能(AI)模型 角膜的粘弹性特性。

PROJECT SUMMARY The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with a line-field Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our previous work has made fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g. cataract surgery, LAISK, corneal cross-linking, and tissue transplants with personalize treatments). The proposed studies will accelerate transition of this technology into clinics, influence our selection and application of corneal surgical treatments and will help us to understand the structural consequences of corneal disease and wound healing: Aim 1. Develop a line-field OCE (LF-OCE) system for ultrafast 3D clinical imaging. Aim 2. In vivo studies with rabbits. Aim 3. Preliminary clinical studies in humans. Aim 4. Refine numerical (FEM) and Artificial Intelligence (AI) models of the depth-dependent nonlinear viscoelastic properties of the cornea.