Optical Coherence Elastography of the Cornea

项目概要 眼睛外层的基本物理特性决定了眼睛的结构特征 眼球并可能在几种破坏性疾病状态下发生改变，包括近视眼轴伸长， 圆锥角膜的病理变形和角膜屈光手术后的医源性角膜扩张。这些 生物力学组织特征不仅影响我们对诊断测试的临床解释，例如 眼压的测量，但已被认为是眼压发展的重要因素。 青光眼。目前，尚无可靠的方法对角膜进行定量测量。 体内弹性。在这里，我们将开发评估角膜弹性特性的新方法，该方法可以 可能用于常规临床诊断和治疗。该方法将充分利用高度 局部气压刺激和压力波传播的超灵敏检测和分析 使用线场光学相干断层扫描在角膜后表面和前表面上进行重建 角膜的体积生物力学特性。我们之前的工作在以下方面取得了根本性进展 通过一种新颖的方法了解角膜生物力学，并在其他领域具有潜在影响力的应用 学科（例如白内障手术、LAISK、角膜交联和个性化组织移植） 治疗）。拟议的研究将加速该技术向临床的过渡，影响我们的选择 以及角膜手术治疗的应用，将有助于我们了解角膜手术的结构后果 角膜疾病和伤口愈合： 目标 1. 开发用于超快 3D 临床成像的线场 OCE (LF-OCE) 系统。 目标 2. 用兔子进行体内研究。 目标 3. 人体初步临床研究。 目标 4. 细化深度相关非线性的数值 (FEM) 和人工智能 (AI) 模型 角膜的粘弹性。

PROJECT SUMMARY The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with a line-field Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our previous work has made fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g. cataract surgery, LAISK, corneal cross-linking, and tissue transplants with personalize treatments). The proposed studies will accelerate transition of this technology into clinics, influence our selection and application of corneal surgical treatments and will help us to understand the structural consequences of corneal disease and wound healing: Aim 1. Develop a line-field OCE (LF-OCE) system for ultrafast 3D clinical imaging. Aim 2. In vivo studies with rabbits. Aim 3. Preliminary clinical studies in humans. Aim 4. Refine numerical (FEM) and Artificial Intelligence (AI) models of the depth-dependent nonlinear viscoelastic properties of the cornea.