Optical Coherence Elastography of the Cornea

角膜光学相干弹性成像

基本信息

批准号：
10441518
负责人：
Salavat R Aglyamov
金额：
$ 39.77万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-06-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10441518
关键词：
3-Dimensional Achievement Agreement Air Pressure Animals Anisotropy Anterior Ants Artificial Intelligence Beds Biological Biomechanics Cataract Extraction Characteristics Clinic Clinical Clinical Research Clinical Treatment Connective Tissue Cornea Corneal Diseases Custom Dependence Detection Development Diagnostic Diagnostic tests Discipline Disease Elasticity Eye Glaucoma Goals Heterogeneity Human Iatrogenesis Image Individual Intervention Keratoconus Knowledge Laser In Situ Keratomileusis Link Location Measurement Measures Methods Modeling Morphologic artifacts Motion Myopia Nature Operative Surgical Procedures Optical Coherence Tomography Optics Oryctolagus cuniculus Outcome Pathologic Patients Physiologic Intraocular Pressure Physiological Property Protocols documentation Reaction Reporting Research Routine Diagnostic Tests Shapes Signal Transduction Speed Structure Surface System Techniques Technology Testing Therapeutic Therapeutic Intervention Time Tissue Transplantation Tissues Training Tunic Validation Variant Work base biomechanical model biomechanical test clinical diagnostics clinical imaging clinical translation clinically significant convolutional neural network corneal epithelial wound healing crosslink deep learning denoising design elastography improved improved outcome in vivo insight mechanical properties models and simulation new technology novel novel strategies personalized medicine physical property pressure response success viscoelasticity visual tracking

项目摘要

PROJECT SUMMARY The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with a line-field Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our previous work has made fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g. cataract surgery, LAISK, corneal cross-linking, and tissue transplants with personalize treatments). The proposed studies will accelerate transition of this technology into clinics, influence our selection and application of corneal surgical treatments and will help us to understand the structural consequences of corneal disease and wound healing: Aim 1. Develop a line-field OCE (LF-OCE) system for ultrafast 3D clinical imaging. Aim 2. In vivo studies with rabbits. Aim 3. Preliminary clinical studies in humans. Aim 4. Refine numerical (FEM) and Artificial Intelligence (AI) models of the depth-dependent nonlinear viscoelastic properties of the cornea.

项目摘要眼睛外衣的基本物理特性决定了眼球球，可能会改变几个毁灭性疾病状态，包括近视的轴向伸长，角膜屈光手术后，角膜结构和医源性角膜切开症的病理变形。这些生物力学组织特征不仅影响我们对诊断测试的临床解释，例如眼内压的测量，但已被认为是发展的重要因素青光眼。当前，没有可靠的可靠方法来对角膜进行定量测量体内弹性。在这里，我们将开发出评估角膜弹性特性的新方法可能用于常规临床诊断和治疗。此方法将具有高度的优势局部气压刺激和超敏感的检测以及压力波传播的分析在角膜后部和前表面，带有线场光学相干断层扫描以重建角膜的体积生物力学特性。我们以前的工作已在通过一种新型方法了解角膜生物力学，并在其他方面具有潜在影响力学科（例如白内障手术，laisk，角膜交联和与个性化的组织移植治疗）。拟议的研究将加速该技术向诊所的过渡，影响我们的选择并应用角膜手术治疗，将有助于我们了解角膜疾病和伤口愈合： AIM 1。开发一个用于超快3D临床成像的线场OCE（LF-OCE）系统。目的2。兔子体内研究。目标3。人类的初步临床研究。目标4。依赖深度依赖性非线性的数值（FEM）和人工智能（AI）模型角膜的粘弹性。