Assessment of cerebrospinal fluid flow

脑脊液流量评估

• 批准号: 8893749
• 负责人: Salavat R Aglyamov
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8893749
• 关键词: Abdomen; Acoustics; Adult; Algorithms; Animal Testing; Architecture; Bolus Infusion; Brain; Brain Injuries; Caliber; Catheters; Cephalic; Cerebral Ventricles; Cerebrospinal Fluid; Cerebrum; Cessation of life; Child; Childhood; Clinical; Computer software; Contrast Media; Creation of ventriculo-peritoneal shunt; Dementia; Development; Devices; Diagnosis; Diagnostic; Diagnostic Imaging; Diagnostic radiologic examination; Disease; Drainage procedure; Extravasation; Generations; Goals; Greater sac of peritoneum; Histology; Hydrocephalus; Hydrostatic Pressure; Image; Imaging Techniques; Implant; Infection; Intracranial Hypertension; Intracranial Pressure; Ionizing radiation; Lead; Left; Liquid substance; MRI Scans; Measurement; Measures; Mechanics; Mediating; Methodology; Methods; Microbubbles; Microscopy; Modeling; Motion; Neuraxis; Obstruction; Operative Surgical Procedures; Outcome; Patients; Peritoneal; Physiologic pulse; Physiological; Prevalence; Protocols documentation; Public Health; Quality of life; Rattus; Real-Time Systems; Research; Resources; Running; Safety; Shunt Device; Signal Transduction; Silicones; Skin; Surface; Survival Rate; Symptoms; System; Techniques; Time; Tissues; Transducers; Ultrasonography; Venous; Ventricular; X-Ray Computed Tomography; absorption; animal tissue; base; cerebrospinal fluid flow; clinically relevant; contrast enhanced; cost; cost effective; cranium; imaging system; improved; infancy; mental development; migration; minimally invasive; novel diagnostics; pre-clinical; pressure; public health relevance; research clinical testing; standard care; tissue phantom; ventricular system

 DESCRIPTION (provided by applicant): Excessive buildup of cerebrospinal fluid (CSF) within the brain's ventricular system (hydrocephalus) is a disease that often seriously damages tissues in the central nervous system and may result in death if left untreated. The estimated prevalence in children is 1 in 500, with the excess intracranial pressure significantly impairing mental development, and often causing cranial bulging if occurring in infancy. Ventriculoperitoneal (VP) shunts have been the standard treatment since the early 1960s and have increased the survival rate and quality of life of pediatric hydrocephalus patients significantly. Despite these gains, malfunction and revision surgery are common occurrences. The rate of malfunction of VP shunts in children is estimated to be 40% in the first year after placement, and 10% per year after that. Current methods for diagnosing shunt malfunctions are often invasive, require ionizing radiation, or are expensive for the patient. The overall goal of te project is to develop a safe, cost-effective method for diagnosing shunt malfunctions using ultrasound. We propose a method for CSF flow assessment in a shunt catheter based on contrast-enhanced real-time ultrasound imaging and simultaneous motion estimation using a 2D cross correlation technique. Compared to current clinical imaging protocols, our approach is minimally invasive, cost-effective, and the examination can be performed in a doctor's office, ultimately saving the patient time and money. The objective of the current proposal is to develop and establish the feasibility of this new diagnostic imaging technique and to validate the methodology with phantom, tissue and animal studies. The immediate expected outcome of this project will be a device and associated software ready for preclinical and preliminary clinical testing.