角膜光学相干弹性成像-猫眼课题宝

角膜光学相干弹性成像

批准号：

10723126

负责人：

Salavat R Aglyamov

金额：

$5.54万

依托单位：

UNIVERSITY OF HOUSTON

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-06-01 至 2024-06-30

来源：

https://reporter.nih.gov/project-details/10723126

关键词：

3-Dimensional Acceleration Achievement Agreement Air Pressure Animals Anisotropy Anterior Ants Artificial Intelligence Beds Biological Biomechanics Cataract Extraction Characteristics Clinic Clinical Clinical Research Clinical Treatment Connective Tissue Cornea Corneal Diseases Dependence Detection Development Diagnostic Diagnostic tests Discipline Disease Elastic Tissue Elasticity Eye Glaucoma Goals Heterogeneity Human Iatrogenesis Image Individual Intervention Keratoconus Knowledge Laser In Situ Keratomileusis Link Location Measurement Measures Methods Modeling Morphologic artifacts Motion Myopia Nature Operative Surgical Procedures Optical Coherence Tomography Optics Oryctolagus cuniculus Outcome Pathologic Patients Physiologic Intraocular Pressure Physiological Property Protocols documentation Reaction Reporting Research Routine Diagnostic Tests Shapes Signal Transduction Speed Structure Surface System Techniques Technology Testing Therapeutic Therapeutic Intervention Time Tissue Transplantation Tissues Training Tunic Validation Variant Work biomechanical model biomechanical test clinical diagnostics clinical imaging clinical translation clinically significant convolutional neural network corneal epithelial wound healing corneal surgery crosslink deep learning denoising design elastography improved improved outcome in vivo insight mechanical properties models and simulation new technology novel novel strategies personalized medicine physical property pressure response success viscoelasticity visual tracking

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PROJECT SUMMARY The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with a line-field Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our previous work has made fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g. cataract surgery, LAISK, corneal cross-linking, and tissue transplants with personalize treatments). The proposed studies will accelerate transition of this technology into clinics, influence our selection and application of corneal surgical treatments and will help us to understand the structural consequences of corneal disease and wound healing: Aim 1. Develop a line-field OCE (LF-OCE) system for ultrafast 3D clinical imaging. Aim 2. In vivo studies with rabbits. Aim 3. Preliminary clinical studies in humans. Aim 4. Refine numerical (FEM) and Artificial Intelligence (AI) models of the depth-dependent nonlinear viscoelastic properties of the cornea.

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