Optical Coherence Elastography of the Cornea

角膜光学相干弹性成像

• 批准号: 10723126
• 负责人: Salavat R Aglyamov
• 金额: $ 5.54万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10723126
• 关键词: 3-Dimensional; Acceleration; Achievement; Agreement; Air Pressure; Animals; Anisotropy; Anterior; Ants; Artificial Intelligence; Beds; Biological; Biomechanics; Cataract Extraction; Characteristics; Clinic; Clinical; Clinical Research; Clinical Treatment; Connective Tissue; Cornea; Corneal Diseases; Dependence; Detection; Development; Diagnostic; Diagnostic tests; Discipline; Disease; Elastic Tissue; Elasticity; Eye; Glaucoma; Goals; Heterogeneity; Human; Iatrogenesis; Image; Individual; Intervention; Keratoconus; Knowledge; Laser In Situ Keratomileusis; Link; Location; Measurement; Measures; Methods; Modeling; Morphologic artifacts; Motion; Myopia; Nature; Operative Surgical Procedures; Optical Coherence Tomography; Optics; Oryctolagus cuniculus; Outcome; Pathologic; Patients; Physiologic Intraocular Pressure; Physiological; Property; Protocols documentation; Reaction; Reporting; Research; Routine Diagnostic Tests; Shapes; Signal Transduction; Speed; Structure; Surface; System; Techniques; Technology; Testing; Therapeutic; Therapeutic Intervention; Time; Tissue Transplantation; Tissues; Training; Tunic; Validation; Variant; Work; biomechanical model; biomechanical test; clinical diagnostics; clinical imaging; clinical translation; clinically significant; convolutional neural network; corneal epithelial wound healing; corneal surgery; crosslink; deep learning; denoising; design; elastography; improved; improved outcome; in vivo; insight; mechanical properties; models and simulation; new technology; novel; novel strategies; personalized medicine; physical property; pressure; response; success; viscoelasticity; visual tracking

PROJECT SUMMARY The fundamental physical properties of the outer tunic of the eye determine the structural characteristics of the ocular globe and may be altered in several devastating disease states including axial elongation in myopia, pathological deformation in keratoconus, and iatrogenic keratoectasia following corneal refractive surgery. These biomechanical tissue characteristics not only influence our clinical interpretation of diagnostic tests, e.g. measurement of intraocular pressure, but have been implicated as important factors in the development of glaucoma. Currently, there is no available reliable method to perform quantitative measurement of corneal elasticity in vivo. Here we will develop novel method for the assessment of corneal elastic properties that could potentially be used for routine clinical diagnostic and treatment. This method will take advantages of highly localized air pressure stimulation and ultra-sensitive detection and analysis of the pressure waves propagation on corneal posterior and anterior surfaces with a line-field Optical Coherence Tomography to reconstruct volumetric biomechanical properties of the cornea. Our previous work has made fundamental advances in the understanding of corneal biomechanics through a novel approach with potentially impactful applications in other disciplines (e.g. cataract surgery, LAISK, corneal cross-linking, and tissue transplants with personalize treatments). The proposed studies will accelerate transition of this technology into clinics, influence our selection and application of corneal surgical treatments and will help us to understand the structural consequences of corneal disease and wound healing: Aim 1. Develop a line-field OCE (LF-OCE) system for ultrafast 3D clinical imaging. Aim 2. In vivo studies with rabbits. Aim 3. Preliminary clinical studies in humans. Aim 4. Refine numerical (FEM) and Artificial Intelligence (AI) models of the depth-dependent nonlinear viscoelastic properties of the cornea.

项目总结

项目成果

Optical coherence elastography for tissue characterization: a review.

• DOI: 10.1002/jbio.201400108
• 发表时间: 2015-04
• 期刊: JOURNAL OF BIOPHOTONICS
• 影响因子: 2.8
• 作者: Wang, Shang;Larin, Kirill V.
• 通讯作者: Larin, Kirill V.

The dynamic deformation of a layered viscoelastic medium under surface excitation.

• DOI: 10.1088/0031-9155/60/11/4295
• 发表时间: 2015-06-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Aglyamov SR;Wang S;Karpiouk AB;Li J;Twa M;Emelianov SY;Larin KV
• 通讯作者: Larin KV

Quantitative methods for reconstructing tissue biomechanical properties in optical coherence elastography: a comparison study.

• DOI: 10.1088/0031-9155/60/9/3531
• 发表时间: 2015-05-07
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Han Z;Li J;Singh M;Wu C;Liu CH;Wang S;Idugboe R;Raghunathan R;Sudheendran N;Aglyamov SR;Twa MD;Larin KV
• 通讯作者: Larin KV

Classifying murine glomerulonephritis using optical coherence tomography and optical coherence elastography.

• DOI: 10.1002/jbio.201500269
• 发表时间: 2016-08
• 期刊: Journal of biophotonics
• 影响因子: 2.8
• 作者: Liu CH;Du Y;Singh M;Wu C;Han Z;Li J;Chang A;Mohan C;Larin KV
• 通讯作者: Larin KV

Noncontact depth-resolved micro-scale optical coherence elastography of the cornea.

• DOI: 10.1364/boe.5.003807
• 发表时间: 2014-11
• 期刊: Biomedical optics express
• 影响因子: 3.4
• 作者: Shang Wang;K. Larin