Improving safety and efficacy of platelet transfusion through systems biology
通过系统生物学提高血小板输注的安全性和有效性
基本信息
- 批准号:9347295
- 负责人:
- 金额:$ 109.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-08-01 至 2019-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAgreementAlgorithmsAllergic ReactionAreaBiochemicalBiologicalBiological PreservationBloodBlood Component RemovalBlood PlateletsCaringCell physiologyCellsComplexComputational TechniqueComputational algorithmComputer SimulationComputing MethodologiesDataData AnalysesData SetDatabasesDevelopmentEffectivenessEnzymesEquipment and supply inventoriesEuropeFormulationGlutathioneHemorrhageHemostatic AgentsHospital CostsIn VitroInterventionLengthLesionLifeLiteratureMachine LearningMathematicsMeasuresMetabolicMetabolic PathwayMethodsModelingPathway interactionsPatientsPhasePhysiologyPlasmaPlatelet TransfusionPreclinical TestingProcessProductionProteomicsReactionRecoveryResourcesRiskSafetySignal PathwaySignal TransductionState HospitalsStatistical Data InterpretationSupplementationSurveysSystems BiologyTechniquesTechnologyTestingTransfusionUnited StatesValidationWorkbasecostdesignexperimental studyhuman subjectimprovedinsightinterestmetabolic profilemetabolomicsmodel designnovelopen innovationoxidative damagepathogenprogramsstatisticssuccesstime usewasting
项目摘要
Project Summary
Platelet transfusion is critical for severely bleeding patients and nearly 6 million units are transfused in the
United States and Europe annually. In the United States, platelets are typically stored for 5 days resulting in a
waste of 20% of their supply. Short storage duration is a consequence of bacterial contamination and platelet
quality considerations. Though many methods have been developed for bacterial testing and pathogen
inactivation, fewer have been developed for improving quality of stored platelets. Platelet additive solutions
have the possibility to increase storage quality and duration, reduce plasma-related allergic reactions, impact
the efficacy of pathogen reduction techniques, and save plasma which can then be used as an additional
transfusion product. While the benefits are well known, there has been little progress in developing new
platelet additive solutions for increasing quality and safety of platelet transfusion because there is a lack of
broad understanding of biochemical and signaling changes during storage. There has been interest to utilize
high-throughput metabolite profiling for global understanding of platelet metabolic decline but data analysis of
complex datasets has been a daunting challenge. In Phase I of this program, we developed the first, robust
computational platform involving statistical analysis and systems biology of metabolic and signaling networks
to interpret and analyze PLT metabolomic and proteomic profiles in a complete network context. Using time-
course global, quantitative metabolite profiling, we determined that PLTs undergo a non-linear decay process
and computationally identified key metabolic enzymes and cellular process that drive this decay. Based on the
computational results, we have devised two novel additive solution strategies to mitigate the decay process
and improve the length of PLT units. In this Phase II proposal, we will validate the computationally determined
additive solutions for efficacy in alleviating the non-linear decay process through 1) metabolomics experiments,
and 2) non-metabolic PLT physiology experiments including cell activation and hemostatic effectiveness. A
successful additive solution will be progressed to media refinement and preclinical testing.
项目摘要
血小板输注对严重出血的患者至关重要,近600万单位的输注
美国和欧洲每年都有。在美国,血小板通常储存5天,导致
浪费了他们供应的20%。储存时间短是细菌污染和血小板的结果
质量方面的考虑。虽然已经开发了许多细菌测试和病原体的方法
失活,但用于改善储存的血小板质量的研究较少。血小板添加剂溶液
有可能提高储存质量和保存时间,减少与血浆相关的过敏反应,影响
减少病原体的功效技术,并节省血浆,然后可以作为额外的
输液产品。虽然好处是众所周知的,但在开发新的
用于提高血小板输注质量和安全性的血小板添加剂溶液,因为缺乏
对储存过程中的生化和信号变化有广泛的了解。人们一直有兴趣利用
高通量代谢物图谱用于全球了解血小板代谢下降,但数据分析
复杂的数据集一直是一项艰巨的挑战。在这个项目的第一阶段,我们开发了第一个健壮的
涉及代谢和信号网络的统计分析和系统生物学的计算平台
在一个完整的网络环境中解释和分析PLT代谢组和蛋白质组学。利用时间-
经过全局的、定量的代谢物分析,我们确定PLT经历了一个非线性的衰变过程
并通过计算确定了推动这种腐烂的关键代谢酶和细胞过程。基于
计算结果,我们设计了两种新的加性解策略来减缓衰变过程
并提高了PLT单元的长度。在此第二阶段提案中,我们将验证通过计算确定的
通过1)代谢组学实验缓解非线性衰退过程的有效性的添加剂溶液,
2)非代谢性PLT生理实验,包括细胞激活和止血效果。一个
成功的添加剂溶液将进行介质精制和临床前试验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Aarash Bordbar其他文献
Aarash Bordbar的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Aarash Bordbar', 18)}}的其他基金
Preclinical development of a novel therapeutic for Parkinson's disease
帕金森病新型疗法的临床前开发
- 批准号:
10913244 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Preclinical development of a novel therapeutic for Parkinson's disease
帕金森病新型疗法的临床前开发
- 批准号:
10324284 - 财政年份:2021
- 资助金额:
$ 109.9万 - 项目类别:
Preclinical development of a novel therapeutic for Parkinson's disease
帕金森病新型疗法的临床前开发
- 批准号:
10619432 - 财政年份:2021
- 资助金额:
$ 109.9万 - 项目类别:
Development of a metabolomics and machine learning based high-throughput screening platform for data-driven drug discovery
开发基于代谢组学和机器学习的高通量筛选平台,用于数据驱动的药物发现
- 批准号:
10343786 - 财政年份:2018
- 资助金额:
$ 109.9万 - 项目类别:
Developing a systems biology platform for predicting, preventing, and treating drug side effects
开发用于预测、预防和治疗药物副作用的系统生物学平台
- 批准号:
9922312 - 财政年份:2016
- 资助金额:
$ 109.9万 - 项目类别:
Improving safety and efficacy of platelet transfusion through systems biology
通过系统生物学提高血小板输注的安全性和有效性
- 批准号:
8977072 - 财政年份:2015
- 资助金额:
$ 109.9万 - 项目类别:
Improving red blood cell transfusion through systems biology
通过系统生物学改善红细胞输注
- 批准号:
8714738 - 财政年份:2014
- 资助金额:
$ 109.9万 - 项目类别:
Improving red blood cell transfusion through systems biology
通过系统生物学改善红细胞输注
- 批准号:
9049084 - 财政年份:2014
- 资助金额:
$ 109.9万 - 项目类别:
相似海外基金
A study for cross borders Indonesian nurses and care workers: Case of Japan-Indonesia Economic Partnership Agreement
针对跨境印度尼西亚护士和护理人员的研究:日本-印度尼西亚经济伙伴关系协定的案例
- 批准号:
22KJ0334 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Challenges of the Paris Agreement Exposed by the Energy Shift by External Factors: The Case of Renewable Energy Policies in Japan, the U.S., and the EU
外部因素导致的能源转移对《巴黎协定》的挑战:以日本、美国和欧盟的可再生能源政策为例
- 批准号:
23H00770 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
NSF-NOAA Interagency Agreement (IAA) for the Global Oscillations Network Group (GONG)
NSF-NOAA 全球振荡网络组 (GONG) 机构间协议 (IAA)
- 批准号:
2410236 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Cooperative Agreement
Conditions for U.S. Agreement on the Closure of Contested Overseas Bases: Relations of Threat, Alliance and Base Alternatives
美国关于关闭有争议的海外基地协议的条件:威胁、联盟和基地替代方案的关系
- 批准号:
23K18762 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
MSI Smart Manufacturing Data Hub – Open Calls Grant Funding Agreement
MSI 智能制造数据中心 – 公开征集赠款资助协议
- 批准号:
900240 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Collaborative R&D
Continuation of Cooperative Agreement between U.S. Food and Drug Administration and S.C. Department of Health and Environmental Control (DHEC) for MFRPS Maintenance.
美国食品和药物管理局与南卡罗来纳州健康与环境控制部 (DHEC) 继续签订 MFRPS 维护合作协议。
- 批准号:
10829529 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
National Ecological Observatory Network Governing Cooperative Agreement
国家生态观测站网络治理合作协议
- 批准号:
2346114 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Cooperative Agreement
The Kansas Department of Agriculture's Flexible Funding Model Cooperative Agreement for MFRPS Maintenance, FPTF, and Special Project.
堪萨斯州农业部针对 MFRPS 维护、FPTF 和特别项目的灵活资助模式合作协议。
- 批准号:
10828588 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Robust approaches for the analysis of agreement between clinical measurements: development of guidance and software tools for researchers
分析临床测量之间一致性的稳健方法:为研究人员开发指南和软件工具
- 批准号:
MR/X029301/1 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Linguistic transfer in a contact variety of Spanish: Gender agreement production and attitudes
博士论文研究:西班牙语接触变体中的语言迁移:性别协议的产生和态度
- 批准号:
2234506 - 财政年份:2023
- 资助金额:
$ 109.9万 - 项目类别:
Standard Grant