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Improving safety and efficacy of platelet transfusion through systems biology

通过系统生物学提高血小板输注的安全性和有效性

基本信息

批准号：
8977072
负责人：
Aarash Bordbar
金额：
$ 22.36万
依托单位：
SINOPIA BIOSCIENCES, INC.
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-08-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8977072
关键词：
Accounting Allergic Reaction Area Biochemical Biochemical Pathway Biological Blood Blood Banks Blood Platelets Caring Cell physiology Characteristics Chemicals Clinical Trials Complex Computing Methodologies Data Data Analyses Data Set Development Equipment and supply inventories Europe Funding Generations Hemorrhage Hospital Costs Human Iceland Intellectual Property Intervention Investigation Kinetics Lesion Life Literature Measures Medicine Metabolic Metabolism Methods Modeling Patients Phase Phenotype Plasma Platelet Transfusion Positioning Attribute Process Proteomics Publishing Resources Risk Role Safety Signal Pathway Signal Transduction Solutions State Hospitals System Systems Biology Techniques Technology Testing Time Transfusion United States Universities Validation Work base commercial application commercialization cost design experience extracellular improved innovation insight interest mathematical model metabolomics model building novel pathogen programs prospective protein metabolite protein profiling public health relevance reconstruction research clinical testing research study statistics success wasting

项目摘要

DESCRIPTION (provided by applicant): Platelet transfusion is critical for severely bleeding patients and nearly 7 million units are transfused in the United States and Europe annually. In the United States, platelets can only be stored for 5 days resulting in a waste of 15% of their supply. Short storage duration is a consequence of bacterial contamination and platelet quality considerations. Though many methods have been developed for bacterial testing and pathogen inactivation, fewer have been developed for improving quality of stored platelets. Platelet additive solutions have the possibility to increase storage quality and duration, reduce plasma-related allergic reactions, impact the efficacy of pathogen reduction techniques, and save plasma which can then be used as an additional transfusion product. While the benefits are well known, there has been little progress in developing new platelet additive solutions for increasing quality and safety of platelet transfusion because there is a lack of broad understanding of biochemical decline during storage. There has been interest to utilize high-throughput metabolite and protein profiling for global understanding of platelet metabolic decline but data analysis of complex datasets has been a daunting challenge. The proposed program will develop the first, robust computational platform involving statistical analysis, systems biology of metabolic and signaling networks, and data-driven kinetic models to fully interpret and analyze platelet metabolite and protein profiles in a complete network context. The program will utilize recently generated time-course global, quantitative metabolite profiling to track intracellular and extracellular platelet metabolites under standard storage conditions and available proteomic studies in literature. The deep biochemical understanding obtained will be employed to quantitatively predict optimal additive solutions based on biological efficacy, cost, and regulator hurdles. Predicted additives will be chosen for experimental validation and testing in Phase II.